Protective effect of total flavonoids from Ixeris Sonchifolia on herpes simplex virus keratitis in mice

BMC Complementary Medicine and Therapies - Tập 20 Số 1 - Trang 1-8 - 2020
Wang, Yong-Qiang1, Cai, Li2, Zhang, Nan3, Zhang, Jing2, Wang, Hai-Hong2, Zhu, Wei1
1Department of Dermatology, Xuanwu Hospital, Capital Medical University, Beijing, China
2Department of Dermatology, Hebei General Hospital, Shijiazhuang, China
3Department of Dermatology, Baoding First Central Hospital, Baoding, China

Tóm tắt

To investigate the protective effect of Ixeris Sonchifolia (Bae.) Hance (ISH) extract on herpes simplex virus keratitis (HSK) in mice. A mouse model of HSK was established by inoculating 60 mice (60 right eyes) with herpes simplex virus type 1 (HSV-1) by corneal scratch. The other 15 mice as blank control only received corneal scratch but without HSV-1. From the 2nd day after the successful modeling, the experimental group was fed with ISH total flavonoids (50, 100 and 200 mg/kg) orally, twice a day for 14 days. The model group and control group were given the same amount of normal saline. The pathological changes of cornea were observed once a day by slit lamp microscopy combined with fluorescein staining. The corneal histopathological examination, the survival status and the serum levels of interleukin-2 (IL-2), IL-4 and interferon-gama (INF-γ) were performed at the end of the experiment. The result showed that ISH could significantly improve the corneal lesion degree, increase mice survival rate, and markedly increase the levels of IL-2 and INF-γ, reduce the levels of IL-4 in serum of mice. ISH could increase the anti-virus ability, promote the healing of corneal inflammation and alleviate the pathological damage of cornea, which suggested that ISH has a potential and valuable therapeutic effect on the HSK.

Tài liệu tham khảo

citation_journal_title=Ocul Surf; citation_title=Pathogenesis of herpes simplex keratitis: the host cell response and ocular surface sequelae to infection and inflammation; citation_author=AM Lobo, AM Agelidis, D Shukla; citation_volume=17; citation_issue=1; citation_publication_date=2019; citation_pages=40-49; citation_doi=10.1016/j.jtos.2018.10.002; citation_id=CR1 citation_journal_title=Curr Opin Ophthalmol; citation_title=Management of herpes simplex virus epithelial keratitis; citation_author=M Roozbahani, KM Hammersmith; citation_volume=29; citation_issue=4; citation_publication_date=2018; citation_pages=360-364; citation_doi=10.1097/ICU.0000000000000483; citation_id=CR2 citation_journal_title=Microbes Infect; citation_title=Application of our understanding of pathogenesis of herpetic stromal keratitis for novel therapy; citation_author=NK Rajasagi, BT Rouse; citation_volume=20; citation_issue=9–10; citation_publication_date=2018; citation_pages=526-530; citation_doi=10.1016/j.micinf.2017.12.014; citation_id=CR3 citation_journal_title=Clin Ophthalmol; citation_title=Herpes simplex keratitis: challenges in diagnosis and clinical management; citation_author=TN Azher, XT Yin, D Tajfirouz, AJ Huang, PM Stuart; citation_volume=11; citation_publication_date=2017; citation_pages=185-191; citation_doi=10.2147/OPTH.S80475; citation_id=CR4 citation_journal_title=Cochrane Database Syst Rev; citation_title=Oral antivirals for preventing recurrent herpes simplex keratitis in people with corneal grafts; citation_author=UK Bhatt, MN Abdul Karim, JI Prydal, SV Maharajan, U Fares; citation_volume=11; citation_publication_date=2016; citation_pages=CD007824; citation_id=CR5 citation_journal_title=Oman J Ophthalmol; citation_title=Recent trends: medical management of infectious keratitis; citation_author=S Solanki, M Rathi, S Khanduja, CS Dhull, S Sachdeva, J Phogat; citation_volume=8; citation_issue=2; citation_publication_date=2015; citation_pages=83-85; citation_doi=10.4103/0974-620X.159104; citation_id=CR6 citation_journal_title=Clin Exp Ophthalmol; citation_title=Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents; citation_author=M Tsatsos, C MacGregor, I Athanasiadis, MM Moschos, P Hossain, D Anderson; citation_volume=44; citation_issue=9; citation_publication_date=2016; citation_pages=824-837; citation_doi=10.1111/ceo.12785; citation_id=CR7 citation_journal_title=J Immunol Res; citation_title=Immunological aspects of acute and recurrent herpes simplex keratitis; citation_author=J Rolinski, I Hus; citation_volume=2014; citation_publication_date=2014; citation_pages=513560; citation_doi=10.1155/2014/513560; citation_id=CR8 citation_journal_title=Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = Chin J Chin Mater Med; citation_title=Systematic review of Kudiezi injection drug safety; citation_author=SS Gao, RZ Cui, YM Xie, X Liao, XY Gao, JD Wang; citation_volume=42; citation_issue=12; citation_publication_date=2017; citation_pages=2380-2390; citation_id=CR9 citation_journal_title=Dis Markers; citation_title=Effects of Kudiezi injection on serum inflammatory biomarkers in patients with acute cerebral infarction; citation_author=X Liu, X Jin, B Chen, X Liu, X Liang, X Fang, H Wu, X Fu, H Zheng, X Ding; citation_volume=2018; citation_publication_date=2018; citation_pages=7936736; citation_id=CR10 citation_journal_title=J Med Food; citation_title=Quantification of major compounds from Ixeris dentata, Ixeris dentata Var. albiflora, and Ixeris sonchifolia and their comparative anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 cells; citation_author=S Karki, HJ Park, A Nugroho, EJ Kim, HA Jung, JS Choi; citation_volume=18; citation_issue=1; citation_publication_date=2015; citation_pages=83-94; citation_doi=10.1089/jmf.2014.3205; citation_id=CR11 citation_journal_title=PLoS One; citation_title=Holistic evaluation of quality consistency of Ixeris sonchifolia (Bunge) Hance Injectables by quantitative fingerprinting in combination with antioxidant activity and Chemometric methods; citation_author=L Yang, G Sun, Y Guo, Z Hou, S Chen; citation_volume=11; citation_issue=2; citation_publication_date=2016; citation_doi=10.1371/journal.pone.0148878; citation_id=CR12 citation_journal_title=Food Chem Toxicol : Int J Published Br Ind Biol Res Assoc; citation_title=Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury; citation_author=YC Zhang, FF Gan, SB Shelar, KY Ng, EH Chew; citation_volume=59; citation_publication_date=2013; citation_pages=272-280; citation_doi=10.1016/j.fct.2013.05.058; citation_id=CR13 citation_journal_title=Arch Pharm Res; citation_title=Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells; citation_author=SB Yee, JH Lee, HY Chung, KS Im, SJ Bae, JS Choi, ND Kim; citation_volume=26; citation_issue=2; citation_publication_date=2003; citation_pages=151-156; citation_doi=10.1007/BF02976662; citation_id=CR14 citation_journal_title=J Microbiol Biotechnol; citation_title=Anti-allergic effects of fermented Ixeris sonchifolia and its constituent in mice; citation_author=HT Trinh, EA Bae, YJ Hyun, YA Jang, HK Yun, SS Hong, DH Kim; citation_volume=20; citation_issue=1; citation_publication_date=2010; citation_pages=217-223; citation_doi=10.4014/jmb.0904.04015; citation_id=CR15 citation_journal_title=J Asian Nat Prod Res; citation_title=Sesquiterpene lactones from Ixeris sonchifolia Hance and their cytotoxicities on A549 human non-small cell lung cancer cells; citation_author=YC Zhang, L Zhou, KY Ng; citation_volume=11; citation_issue=4; citation_publication_date=2009; citation_pages=294-298; citation_doi=10.1080/10286020902727520; citation_id=CR16 citation_journal_title=Clin Chimica Acta; Int J Clin Chem; citation_title=Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils; citation_author=J Lu, X Feng, Q Sun, H Lu, M Manabe, K Sugahara, D Ma, Y Sagara, H Kodama; citation_volume=316; citation_issue=1–2; citation_publication_date=2002; citation_pages=95-99; citation_doi=10.1016/S0009-8981(01)00725-2; citation_id=CR17 citation_journal_title=Nat Prod Commun; citation_title=Two new sesquiterpene lactones from Ixeris sonchifolia; citation_author=SJ Song, LY Zhou, LZ Li, PY Gao, WW Jia, Y Peng; citation_volume=6; citation_issue=8; citation_publication_date=2011; citation_pages=1055-1057; citation_id=CR18 citation_journal_title=J Asian Nat Prod Res; citation_title=Sesquiterpene lactones from Ixeris sonchifolia (Bge.) Hance II; citation_author=WZ Zhang, XL Li, LG Shi, JL Wang, M Zhao, DF Zhao, SJ Zhang; citation_volume=10; citation_issue=11–12; citation_publication_date=2008; citation_pages=1087-1091; citation_doi=10.1080/10286020802361180; citation_id=CR19 citation_journal_title=J Asian Nat Prod Res; citation_title=A new sesquiterpene lactone glucoside from Ixeris sonchifolia; citation_author=XZ Feng, SX Xu, M Dong; citation_volume=3; citation_issue=4; citation_publication_date=2001; citation_pages=247-251; citation_doi=10.1080/10286020108040363; citation_id=CR20 citation_journal_title=Planta Med; citation_title=Three new triterpenoid saponins from Ixeris sonchifolia and their cytotoxic activity; citation_author=XZ Feng, M Dong, ZJ Gao, SX Xu; citation_volume=69; citation_issue=11; citation_publication_date=2003; citation_pages=1036-1040; citation_doi=10.1055/s-2003-45152; citation_id=CR21 citation_journal_title=Arch Pharm Res; citation_title=Cytotoxic constituents of the leaves of Ixeris sonchifolia; citation_author=J Suh, Y Jo, ND Kim, SJ Bae, JH Jung, KS Im; citation_volume=25; citation_issue=3; citation_publication_date=2002; citation_pages=289-292; citation_doi=10.1007/BF02976628; citation_id=CR22 citation_journal_title=Die Pharmazie; citation_title=A new triterpenoidal saponin from Ixeris sonchifolia and its cytotoxic activity; citation_author=XZ Feng, M Dong, SX Xu; citation_volume=56; citation_issue=8; citation_publication_date=2001; citation_pages=663-664; citation_id=CR23 citation_journal_title=Specl Wild Econ Anim Plant Res; citation_title=Study on the extraction process of total flavonoids from Ixeris sonchifolia (Bge.) Hance; citation_author=Y Chen, X Jiang, H Luo, R Jiang; citation_volume=1; citation_issue=6; citation_publication_date=2011; citation_pages=29-54; citation_id=CR24 citation_journal_title=Arch Ophthalmol; citation_title=Assessment of diclofenac on herpes keratitis in rabbit eyes; citation_author=MD Trousdale, WE Barlow, LJ McGuigan; citation_volume=107; citation_issue=11; citation_publication_date=1989; citation_pages=1664-1666; citation_doi=10.1001/archopht.1989.01070020742039; citation_id=CR25 citation_journal_title=Am J Ophthalmol; citation_title=Latanoprost increases the severity and recurrence of herpetic keratitis in the rabbit; citation_author=HE Kaufman, ED Varnell, HW Thompson; citation_volume=127; citation_issue=5; citation_publication_date=1999; citation_pages=531-536; citation_doi=10.1016/S0002-9394(99)00089-6; citation_id=CR26 citation_journal_title=Trans Am Ophthalmol Soc; citation_title=Valacyclovir for the prevention of recurrent herpes simplex virus eye disease after excimer laser photokeratectomy; citation_author=PA Asbell; citation_volume=98; citation_publication_date=2000; citation_pages=285-303; citation_id=CR27 citation_journal_title=Prog Retin Eye Res; citation_title=Herpes keratitis; citation_author=AM Rowe, AJ St Leger, S Jeon, DK Dhaliwal, JE Knickelbein, RL Hendricks; citation_volume=32; citation_publication_date=2013; citation_pages=88-101; citation_doi=10.1016/j.preteyeres.2012.08.002; citation_id=CR28 Harris KD. Herpes Simplex Virus Keratitis. Home Healthc Now. 2019;37(5):281–4. citation_journal_title=Rev Med Virol; citation_title=Toll-like receptors as novel therapeutic targets for herpes simplex virus infection; citation_author=R Jahanban-Esfahlan, K Seidi, M Majidinia, A Karimian, B Yousefi, SM Nabavi, A Astani, I Berindan-Neagoe, D Gulei, F Fallarino; citation_volume=29; citation_issue=4; citation_publication_date=2019; citation_pages=e2048; citation_id=CR30 citation_journal_title=Pediatr Infect Dis J; citation_title=Management of Herpes Simplex Virus Keratitis in the pediatric population; citation_author=JC Serna-Ojeda; citation_volume=38; citation_issue=7; citation_publication_date=2019; citation_pages=e164; citation_doi=10.1097/INF.0000000000002226; citation_id=CR31 citation_journal_title=Cornea; citation_title=Therapeutic challenges and prognosis of Descemet's membrane endothelial Keratoplasty in herpes simplex eye disease; citation_author=Y Abdelmassih, P Dubrulle, C Sitbon, S El-Khoury, D Guindolet, S Doan, M Labetoulle, I Cochereau, EE Gabison; citation_volume=38; citation_issue=5; citation_publication_date=2019; citation_pages=553-558; citation_doi=10.1097/ICO.0000000000001891; citation_id=CR32 Whitley R, Baines J. Clinical management of herpes simplex virus infections: past, present, and future. F1000Research. 2018;7. https://doi.org/10.12688/f1000research.16157.1 . citation_journal_title=Immunotherapy; citation_title=Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis; citation_author=R Tang, Y Zhai, L Dong, T Malla, K Hu; citation_volume=10; citation_issue=3; citation_publication_date=2018; citation_pages=189-200; citation_doi=10.2217/imt-2017-0060; citation_id=CR34 citation_journal_title=Am J Case Rep; citation_title=New therapeutic perceptions in a patient with complicated herpes simplex virus 1 keratitis: a case report and review of the literature; citation_author=D Kalogeropoulos, A Geka, K Malamos, M Kanari, C Kalogeropoulos; citation_volume=18; citation_publication_date=2017; citation_pages=1382-1389; citation_doi=10.12659/AJCR.906506; citation_id=CR35 citation_journal_title=Invest Ophthalmol Vis Sci; citation_title=Evaluating corneal fluorescein staining using a novel automated method; citation_author=F Amparo, H Wang, J Yin, A Marmalidou, R Dana; citation_volume=58; citation_issue=6; citation_publication_date=2017; citation_pages=BIO168-BIO173; citation_doi=10.1167/iovs.17-21831; citation_id=CR36 citation_journal_title=Cont Lens Anterior Eye; citation_title=Fluorescein staining and physiological state of corneal epithelial cells; citation_author=KL Bandamwar, EB Papas, Q Garrett; citation_volume=37; citation_issue=3; citation_publication_date=2014; citation_pages=213-223; citation_doi=10.1016/j.clae.2013.11.003; citation_id=CR37 citation_journal_title=Invest Ophthalmol Vis Sci; citation_title=Evaluation of corneal damage after lacrimal gland excision in male and female mice; citation_author=NE Mecum, D Cyr, J Malon, D Demers, L Cao, ID Meng; citation_volume=60; citation_issue=10; citation_publication_date=2019; citation_pages=3264-3274; citation_doi=10.1167/iovs.18-26457; citation_id=CR38 Woods J, Hutchings N, Srinivasan S, Jones L. Geographic distribution of corneal staining in symptomatic dry eye. Ocul Surf. 2019. citation_journal_title=Virol J; citation_title=Macrophages and cytokines in the early defence against herpes simplex virus; citation_author=S Ellermann-Eriksen; citation_volume=2; citation_publication_date=2005; citation_pages=59; citation_doi=10.1186/1743-422X-2-59; citation_id=CR40