Protective effect of gypenoside LXXV from Gynostemma pentaphyllum against oxidative stress-induced retinal degeneration in vitro and in vivo

Ahn, 2019, The effects of intravitreal sodium iodate injection on retinal degeneration following vitrectomy in rabbits, Sci. Rep., 9, 15696, 10.1038/s41598-019-52172-y

Akhtar-Schafer, 2018, Modulation of three key innate immune pathways for the most common retinal degenerative diseases, EMBO Mol. Med., 10, e8259, 10.15252/emmm.201708259

Alhasani, 2018, Gypenosides protect retinal pigment epithelium cells from oxidative stress, Food Chem. Toxicol., 112, 76, 10.1016/j.fct.2017.12.037

Alves, 2020, Microglia contribution to the regulation of the retinal and choroidal vasculature in age-related macular degeneration, Cells, 9, 1217, 10.3390/cells9051217

Ambati, 2013, Immunology of age-related macular degeneration, Nat. Rev. Immunol., 13, 438, 10.1038/nri3459

Ammar, 2020, Age-related macular degeneration therapy: a review, Curr. Opin. Ophthalmol., 31, 215, 10.1097/ICU.0000000000000657

Bian, 2017, Combination of ginsenoside rb1 and rd protects the retina against bright light-induced degeneration, Sci. Rep., 7, 6015, 10.1038/s41598-017-06471-x

Campbell, 2013, An eye on the future of inflammasome and drug development in AMD, J. Mol. Med., 90, 1059, 10.1007/s00109-013-1050-0

Chakravarthy, 2010, Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis, BMC Ophthalmol., 10, 31, 10.1186/1471-2415-10-31

Chen, 2012, Protective inflammasomes activation in AMD, Nat. Med., 18, 658, 10.1038/nm.2761

Cheng, 2008, Antioxidant effect of hydralazine on retinal pigment epithelial cells and its potential use in the therapy of age-related macular degeneration, Int. J. Ophthalmol., 8, 1059

Coleman, 2018, Treatment of macular degeneration with sildenafil: results of a two-year trial, Ophthalmologica, 240, 45, 10.1159/000486105

Ding, 2017, Activated microglia induce the production of reactive oxygen species and promote apoptosis of co-cultured retinal microvascular pericytes, Graefes Arch. Clin. Exp. Ophthalmol., 255, 777, 10.1007/s00417-016-3578-5

Dou, 2020, Small-molecule modulation of PPARs for the treatment of prevalent vascular retinal diseases, Int. J. Mol. Sci., 21, 9251, 10.3390/ijms21239251

Gurib-Fakim, 2006, Medicinal plants: traditions of yesterday and drugs of tomorrow, Mol. Asp. Med., 27, 1, 10.1016/j.mam.2005.07.008

Hanus, 2016, Current therapeutic developments in atrophic age-related macular degeneration, Br. J. Ophthalmol., 100, 122, 10.1136/bjophthalmol-2015-306972

Huynh, 2013, Botanical compounds: effects on major eye diseases, Evid. - Based Complement. Altern. Med., 2013, 10.1155/2013/549174

Khaliq, 1996, Oxygen modulates the response of the retinal pigment epithelium to basic fibroblast growth factor and epidermal growth factor by receptor regulation, Invest. Ophthalmol. Vis. Sci., 37, 436

Kim, 2017, Role of ginsenosides, the main active components of panax ginseng, in inflammatory responses and diseases, J. Ginseng Res., 41, 435, 10.1016/j.jgr.2016.08.004

Kim, 2020, Ginseng for an eye: effects of ginseng on ocular diseases, J. Ginseng Res., 44, 1, 10.1016/j.jgr.2018.11.006

Lee, 2020, Pharmaceutical efficacy of gypenoside LXXV on non-alcoholic steatohepatitis (NASH), Biomolecules, 10, 1426, 10.3390/biom10101426

Lee, 2020, Molecular drug discovery of single ginsenoside compounds as a potent bruton's tyrosine kinase inhibitor, Int. J. Mol. Sci., 21, 3065, 10.3390/ijms21093065

Lin, 2016, A glimpse at the aging eye, NPJ Aging Mech. Dis., 2, 16003, 10.1038/npjamd.2016.3

Marc, 2008, Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration, Mol. Vis., 14, 782

Rohowetz, 2018, Reactive oxygen species-mediated damage of retinal neurons: drug development targets for therapies of chronic neurodegeneration of the retina, Int. J. Mol. Sci., 19, 3362, 10.3390/ijms19113362

Schmitt, 2017, Pharmacokinetic aspects of retinal drug delivery, Prog. Retin. Eye Res., 57, 134, 10.1016/j.preteyeres.2016.12.001

Smith, 2001, Risk factors for age-related macular degeneration: pooled findings from three continents, Ophthalmol, 108, 697, 10.1016/S0161-6420(00)00580-7

Stanton, 2014, Inflammatory biomarkers for AMD, Retinal Degener. Dis., 801, 251, 10.1007/978-1-4614-3209-8_32

Wang, 2020, Ginsenosides induce extensive changes in gene expression and inhibit oxidative stress-induced apoptosis in human lens epithelial cells, BMC Complement. Med. Ther., 20, 44, 10.1186/s12906-020-2826-8

Zhang, 2020, Gypenosides prevent H2O2-induced retinal ganglion cell apoptosis by concurrently suppressing the neuronal oxidative stress and inflammatory response, J. Mol. Neurosci., 70, 618, 10.1007/s12031-019-01468-9

Yanoga, 2018, Sildenafil citrate induced retinal toxicity-electroretinogram, optical coherence tomography, and adaptive optics findings, Retin. Cases Brief Rep., 12, S33, 10.1097/ICB.0000000000000708