Probiotics Reduce Enterohemorrhagic Escherichia coli O157:H7- and Enteropathogenic E. coli O127:H6-Induced Changes in Polarized T84 Epithelial Cell Monolayers by Reducing Bacterial Adhesion and Cytoskeletal Rearrangements

Infection and Immunity - Tập 73 Số 8 - Trang 5183-5188 - 2005
Philip M. Sherman1, Kathene C. Johnson‐Henry1, Helen P. Yeung1, Peter S. C. Ngo1, J. Goulet2, Thomas A. Tompkins3
1Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario
2Laval University, Quebec City, Quebec
3Institut Rosell-Lallemand Inc., Montreal, Quebec, Canada

Tóm tắt

ABSTRACT The aim of this study was to determine if probiotics reduce epithelial injury following exposure to Escherichia coli O157:H7 and E. coli O127:H6. The pretreatment of intestinal (T84) cells with lactic acid-producing bacteria reduced the pathogen-induced drop in transepithelial electrical resistance. These findings demonstrate that probiotics prevent epithelial injury induced by attaching-effacing bacteria.

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