Proautophagic Drugs: A Novel Means to Combat Apoptosis-Resistant Cancers, with a Special Emphasis on Glioblastomas

Oncologist - Tập 12 Số 12 - Trang 1395-1403 - 2007
Florence Lefranc1,2, Vincenzo Facchini3, Róbert Kiss2
1aDepartment of Neurosurgery, Erasme University Hospital, Brussels, Belgium
2b Laboratory of Toxicology, Institute of Pharmacy, Université Libre de Bruxelles, Brussels, Belgium
3cUnibioscreen SA, Brussels, Belgium

Tóm tắt

Learning Objectives

After completing this course, the reader will be able to: Describe the pathways involved in the natural resistance of cancer cells to cytotoxic insults including radio-/chemotherapy.Explain autophagic cell death as a potent alternative tumor-suppressing mechanism.Identify the common targets in apoptosis and autophagy resistance pathways and the surrogate markers that could be used in clinical practice for proautophagic therapy.Discuss the rationale for incorporating endoplasmic reticulum stress inhibitors as adjuvant chemotherapies against apoptosis-resistant cancers.

Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com

Từ khóa


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