Primary sensitization to inhalant allergens

Pediatric Allergy and Immunology - Tập 11 Số s13 - Trang 9-11 - 2000
Claudia Macaubas1, Susan L. Prescott1, T. Venaille1, Barbara J. Holt1, Troy B. Smallacombe1, Peter D. Sly1, Patrick G. Holt1
1Division of Cell Biology, TVW Telethon Institute for Child Health Research, Perth, Australia (affiliated with The University of Western Australia)

Tóm tắt

The neonatal T‐cell system is capable of responding to allergens at birth, indicating the occurrence of prenatal sensitization, and the cytokine profile of these responses is skewed towards the Th‐2 type. This response is further modified by postnatal exposure to different types of allergens. In relation to inhalant allergen (employed by HDM) the low level fetal Th‐2 responses in non‐atopics appear to be down‐regulated rapidly after birth, parallel to an increase in allergen‐specific IFN‐γ production. In contrast, atopics appear to consolidate their initial Th‐2 responses, and around the age of 6 exhibit a cytokine response profile similar to the adult pattern. A pre‐existing deficiency in IFN‐γ production may be one of the key factors determining the postnatal persistence of Th‐2 responses in atopics.

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Tài liệu tham khảo

10.1136/adc.67.8.1003

10.1159/000236541

Prescott SL, 1998, Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T‐cell responses towards the Th‐2 cytokine profile, J Immunol, 160, 4730, 10.4049/jimmunol.160.10.4730

10.1111/j.1399-3038.1996.tb00117.x

10.1084/jem.183.4.1297

10.1016/s0167-5699(97)01127-4

10.1046/j.1365-2222.1998.00321.x

10.1084/jem.183.4.1613

10.1111/j.1399-3038.1995.tb00264.x

10.1111/j.1365-2222.1995.tb01111.x

10.1111/j.1365-2222.1997.tb01170.x

10.1016/s0140-6736(98)05104-6

10.1073/pnas.91.23.10762

MacaubasC SlyPD BurtonP et al.Regulation of Th‐cell responses to inhalant allergen during early childhood.Clin Exp Allergy1999;29:12231231.

10.1111/j.1365-2222.1992.tb00135.x

10.1111/j.1399-3038.1993.tb00068.x

10.1111/j.1365-2222.1994.tb00930.x

Noble A, 1993, Generation of rat Th2‐like cells in vitro is interleukin‐4‐dependent and inhibited by interferon‐gamma, Immunology, 79, 562

10.1111/j.1398-9995.1997.tb01230.x

10.1016/S0140-6736(05)78871-1

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Thông tin xuất bản

Pediatric Allergy and Immunology

Tập 11 Số s13

9-11

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