Prevalence in the United States of aac(6 ′ ) - Ib - cr Encoding a Ciprofloxacin-Modifying Enzyme

Antimicrobial Agents and Chemotherapy - Tập 50 Số 11 - Trang 3953-3955 - 2006
Chi Hye Park1, Ari Robicsek2, George A. Jacoby3, Daniel F. Sahm4, David C. Hooper1
1Massachusetts General Hospital, Boston, Massachusetts
2Evanston Northwestern Healthcare, Evanston, Illinois
3Lahey Clinic, Burlington, Massachusetts
4Focus BioInova, Herndon, Virginia

Tóm tắt

ABSTRACT Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of ≥0.25 μg/ml and reduced susceptibility to ceftazidime, aac(6 ′ )-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6 ′ )-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli , equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes.

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Tài liệu tham khảo

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Thông tin xuất bản

Antimicrobial Agents and Chemotherapy

Tập 50 Số 11

3953-3955

Thông tin tác giả