Prevalence and Drivers of COVID-19 Vaccine Hesitancy among Czech University Students: National Cross-Sectional Study

Vaccines - Tập 9 Số 9 - Trang 948
Abanoub Riad1,2, Andrea Pokorná1,3, Natália Antalová3,2, Martin Krobot2, Nutsa Zviadadze2, Іryna Serdiuk2, Michal Koščík2, Miloslav Klugar1,2
1Czech National Centre for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC: JBI Centre of Excellence, Masaryk University GRADE Centre), Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
2Department of Public Health, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
3Department of Nursing and Midwifery, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic

Tóm tắt

Background: university students are believed to retain the highest levels of health literacy. They are perceived as the opinion leaders within their communities; therefore, their health-related beliefs and attitudes are deemed important for public health campaigns. This study aimed to investigate the COVID-19 vaccine hesitancy drivers among university students in the Czech Republic. Methods: a cross-sectional study using a self-administered questionnaire was carried out in the weeks before the unrestricted vaccine deployment to Czech adults. The questionnaire had 21 multiple-choice items stratified in 4 categories; demographic characteristics, COVID-19-related anamnesis and influenza vaccine experience, attitudes towards COVID-19 vaccination, and the possible drivers of COVID-19 vaccine hesitancy suggested by the WHO-SAGE. Results: out of the 1351 included students, 66.8% were females, 84.5% were Czech nationals, and 40.6% enrolled in healthcare programs. The overall COVID-19 vaccine acceptance level was 73.3%, 19.3% of participants were vaccine-resistant, and only 7.4% were vaccine-hesitant. Trust in the pharmaceutical industry, trust in healthcare providers, and perceived knowledge sufficiency predicted higher odds of vaccine acceptance. In contrast, media and social media, personal beliefs, immunity misconception, previous COVID-19 infection, and suspicions about novel vaccines and the local availability predicted higher odds of vaccine hesitancy. Conclusions: The findings of this study predict a fair probability to achieve community immunity (herd immunity) among the target population group. The primary prevention strategies in the Czech Republic need to be culturally sensitive and inclusive for foreign nationals. As one-quarter of the participating students are dependent on vaccine safety data, this study findings support the call for independent studies evaluating the side effects of COVID-19 vaccines.

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Tài liệu tham khảo

(2021, February 06). Vaccines and Immunization. Available online: https://www.who.int/health-topics/vaccines-and-immunization#tab=tab_1.

Gavi—The Vaccine Alliance (2021, July 01). In Immunisation: Strengthening Primary Healthcare for Universal Health Coverage Immunisation-A Platform for Strengthening Primary Health Care. Available online: www.gavi.org.

National Institutes of Health (NIH) (2021, August 20). Health Literacy. Clear Communication, Available online: https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/clear-communication/health-literacy.

Riad, A., Abdulqader, H., Morgado, M., Domnori, S., Koščík, M., Mendes, J., Klugar, M., Kateeb, E., and Iads-Score, O.B.O. (2021). Global Prevalence and Drivers of Dental Students’ COVID-19 Vaccine Hesitancy. Vaccines, 9.

Alawia, 2021, Knowledge and attitudes among dental students about COVID-19 and its precautionary measures: A cross-sectional study, J. Oral. Med. Oral. Surg., 27, 17, 10.1051/mbcb/2020056

Alawia, R., Riad, A., and Kateeb, E. (2020). Risk perception and readiness of dental students to treat patients amid COVID-19: Implication for dental education. Oral. Dis., early review.

Yildiz, 2011, Self Reported Dental Health Attitudes and Behaviour of Dental Students in Turkey, Eur. J. Dent., 5, 253, 10.1055/s-0039-1698889

Jackson, 2000, Knowledge, beliefs and behavior related to oral health among Tanzanian and Ugandan teacher trainees, Acta Odontol. Scand., 58, 11, 10.1080/000163500429370

Vozikis, 2014, Health literacy among university students in Greece: Determinants and association with self-perceived health, health behaviours and health risks, Arch. Public Health, 72, 15, 10.1186/2049-3258-72-15

Juvinyà-Canal, D., Suñer-Soler, R., Porquet, A.B., Vernay, M., Blanchard, H., and Bertran-Noguer, C. (2020). Health Literacy among Health and Social Care University Students. Int. J. Environ. Res. Public Health, 17.

Riad, A., Klugar, M., and Krsek, M. (2020). COVID-19-Related Oral Manifestations: Early Disease Features?. Oral. Dis., 30.

Hocková, B., Riad, A., Valky, J., Šulajová, Z., Stebel, A., Slávik, R., Bečková, Z., Pokorná, A., Klugarová, J., and Klugar, M. (2021). Oral Complications of ICU Patients with COVID-19: Case-Series and Review of Two Hundred Ten Cases. J. Clin. Med., 10.

Riad, A., Kassem, I., Hockova, B., Badrah, M., and Klugar, M. (2020). Tongue Ulcers Associated with SARS-COV-2 Infection: A case-series. Oral. Dis., 25.

Riad, 2021, Halitosis in COVID-19 patients, Spéc. Care Dent., 41, 282, 10.1111/scd.12547

Riad, A., Gad, A., Hockova, B., and Klugar, M. (2020). Oral candidiasis in non-severe COVID-19 patients: Call for antibiotic stewardship. Oral. Surg., 9.

Riad, 2021, Oral candidiasis of COVID-19 patients: Case report and review of evidence, J. Cosmet. Dermatol., 20, 1580, 10.1111/jocd.14066

Riad, A., Kassem, I., Badrah, M., and Klugar, M. (2020). Acute parotitis as a presentation of COVID-19?. Oral. Dis.

Riad, 2020, The manifestation of oral mucositis in COVID-19 patients: A case-series, Dermatol. Ther., 33, e14479, 10.1111/dth.14479

Riad, A., Kassem, I., Issa, J., Badrah, M., and Klugar, M. (2020). Angular cheilitis of COVID-19 patients: A case-series and literature review. Oral. Dis., 23.

Riad, 2021, Aphthous stomatitis in COVID-19 patients: Case-series and literature review, Dermatol. Ther., 34, e14735, 10.1111/dth.14735

Riad, 2020, Aphthous-like stomatitis of COVID-19 patients, Braz. J. Oral. Sci., 19, e201354

Wollina, U., Karadağ, A.S., Rowland-Payne, C., Chiriac, A., and Lotti, T. (2020). Cutaneous signs in COVID -19 patients: A review. Dermatol. Ther., 33.

Wollina, 2020, Challenges of COVID-19 pandemic for dermatology, Dermatol. Ther., 33, e13430, 10.1111/dth.13430

Abrams, 2020, Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review, J. Pediatr., 226, 45, 10.1016/j.jpeds.2020.08.003

Ackerson, 2021, Pediatric Vaccination During the COVID-19 Pandemic, Pediatrics, 148, e2020047092, 10.1542/peds.2020-047092

Santoli, 2020, Effects of the COVID-19 Pandemic on Routine Pediatric Vaccine Ordering and Administration—United States, 2020, MMWR Morb. Mortal. Wkly. Rep., 69, 591, 10.15585/mmwr.mm6919e2

EurekAlert (2021, July 01). Child Vaccination Rates Declined during COVID-19 Pandemic. Science News. Available online: https://www.eurekalert.org/pub_releases/2021-04/kp-cvr041521.php.

MacDonald, 2015, Vaccine hesitancy: Definition, scope and determinants, Vaccine, 33, 4161, 10.1016/j.vaccine.2015.04.036

Geoghegan, 2020, Vaccine Safety: Myths and Misinformation, Front. Microbiol., 11, 372, 10.3389/fmicb.2020.00372

Taylor, 1999, Autism and measles, mumps, and rubella vaccine: No epidemiological evidence for a causal association, Lancet, 353, 2026, 10.1016/S0140-6736(99)01239-8

(2021, July 01). Ten Health Issues WHO Will Tackle This Year—World Health Organization. Available online: https://www.who.int/news-room/spotlight/ten-threats-to-global-health-in-2019.

Patel, 2019, National Update on Measles Cases and Outbreaks—United States, January 1–October 1, 2019, MMWR. Morb. Mortal. Wkly. Rep., 68, 893, 10.15585/mmwr.mm6840e2

(2021, July 01). A Comprehensive Guide to Vaccination in the Czech Republic: Updated 5 May 2021—Prague, Czech Republic. Available online: https://www.expats.cz/czech-news/article/vaccination-in-the-czech-republic-all-you-need-to-know.

Ministerstvo Vnitra (2021, June 20). Vaccination Timeline. Covid Portál, Available online: https://covid.gov.cz/en/situations/register-vaccination/vaccination-timeline.

KoBoToolbox.org (2021, August 15). KoBoToolbox. Harvard Humanitarian Initiative. Available online: https://support.kobotoolbox.org/welcome.html.

Saied, 2021, Vaccine hesitancy: Beliefs and barriers associated with COVID-19 vaccination among Egyptian medical students, J. Med. Virol., 93, 4280, 10.1002/jmv.26910

Szmyd, B., Bartoszek, A., Karuga, F.F., Staniecka, K., Błaszczyk, M., and Radek, M. (2021). Medical Students and SARS-CoV-2 Vaccination: Attitude and Behaviors. Vaccines, 9.

Lucia, V.C., Kelekar, A., and Afonso, N.M. (2020). COVID-19 vaccine hesitancy among medical students. J. Public Health, fdaa230.

Masaryk University (2021, June 20). Clubs & Associations at the Faculty of Medicine. Available online: https://www.muni.cz/en/students/student-clubs-associations/contact-1/faculty-of-medicine.

European Comission (2021, June 20). Czech Republic: Tertiary Education. EURYDICE. Available online: https://eacea.ec.europa.eu/national-policies/eurydice/content/higher-education-21_cs.

McHugh, 2012, Interrater reliability: The kappa statistic, Biochem. Med., 22, 276, 10.11613/BM.2012.031

Strategic Advisory Group of Experts on Immunization (SAGE) (2021, March 14). Vaccine Hesitancy Survey Questions Related to SAGE Vaccine Hesitancy Matrix. Available online: https://www.who.int/immunization/programmes_systems/Survey_Questions_Hesitancy.pdf.

World Medical Association (2013). World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA, 310, 2191–2194.

Altman, 2007, Strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies, Br. Med. J., 335, 806, 10.1136/bmj.39335.541782.AD

(2021, July 01). GDPR General Data Protection Regulation, Complete Guide to GDPR Compliance. Available online: https://gdpr.eu/.

SPSS Inc. (2020, October 14). IBM SPSS Statistics 27. Available online: https://www.ibm.com/support/pages/node/3006603.

Al-Mulla, R., Abu-Madi, M., Talafha, Q., Tayyem, R., and Abdallah, A. (2021). COVID-19 Vaccine Hesitancy in a Representative Education Sector Population in Qatar. Vaccines, 9.

Tavolacci, M., Dechelotte, P., and Ladner, J. (2021). COVID-19 Vaccine Acceptance, Hesitancy, and Resistancy among University Students in France. Vaccines, 9.

Synnott, K. (2020). College Students’ COVID-19 Vaccine Hesitancy. SSRN Electron J.

Sallam, M., Dababseh, D., Eid, H., Hasan, H., Taim, D., Al-Mahzoum, K., Al-Haidar, A., Yaseen, A., Ababneh, N., and Assaf, A. (2021). Low COVID-19 Vaccine Acceptance Is Correlated with Conspiracy Beliefs among University Students in Jordan. Int. J. Environ. Res. Public Health, 18.

Barello, 2020, ‘Vaccine hesitancy’ among university students in Italy during the COVID-19 pandemic, Eur. J. Epidemiol., 35, 781, 10.1007/s10654-020-00670-z

Czech Statistical Office (2020, July 01). Statistical Yearbook of the Czech Republic—2020. Yearsbooks. Available online: https://www.czso.cz/csu/czso/statistical-yearbook-of-the-czech-republic-2020.

Patelarou, 2021, Factors influencing nursing students’ intention to accept COVID-19 vaccination: A pooled analysis of seven European countries, Nurse Educ. Today, 104, 105010, 10.1016/j.nedt.2021.105010

Sovicova, M., Zibolenova, J., Svihrova, V., and Hudeckova, H. (2021). Odds Ratio Estimation of Medical Students’ Attitudes towards COVID-19 Vaccination. Int. J. Environ. Res. Public Health, 18.

da Silva, D.T., Biello, K., Lin, W., Valente, P., Mayer, K., Hightow-Weidman, L., and Bauermeister, J. (2021). COVID-19 Vaccine Acceptance among an Online Sample of Sexual and Gender Minority Men and Transgender Women. Vaccines, 9.

Walker, A., Zhang, T., Peng, X.-Q., Ge, J.-J., Gu, H., and You, H. (2021). Vaccine Acceptance and Its Influencing Factors: An Online Cross-Sectional Study among International College Students Studying in China. Vaccines, 9.

Alabdulla, 2021, COVID-19 vaccine hesitancy and attitudes in Qatar: A national cross-sectional survey of a migrant-majority population, Influenza Other Respir. Viruses, 15, 361, 10.1111/irv.12847

Ministry of Health of the Czech Republic (MZCR) (2021, July 01). Vaccinating foreign nationals against COVID-19 in CZ. Aktuální informace o COVID-19. Available online: https://koronavirus.mzcr.cz/en/vaccinating-foreign-nationals-against-covid-19-in-cz/.

Jain, 2021, COVID-19 vaccine hesitancy among medical students in India, Epidemiol. Infect., 149, 1, 10.1017/S0950268821001205

Kelekar, 2021, COVID-19 vaccine acceptance and hesitancy among dental and medical students, J. Am. Dent. Assoc., 152, 596, 10.1016/j.adaj.2021.03.006

Papagiannis, D., Tsimtsiou, Z., Chatzichristodoulou, I., Adamopoulou, M., Kallistratos, I., Pournaras, S., Arvanitidou, M., and Rachiotis, G. (2016). Hepatitis B Virus Vaccination Coverage in Medical, Nursing, and Paramedical Students: A Cross-Sectional, Multi-Centered Study in Greece. Int. J. Environ. Res. Public Health, 13.

Loulergue, 2013, Vaccine coverage of healthcare students in hospitals of the Paris region in 2009: The Studyvax Survey, Vaccine, 31, 2835, 10.1016/j.vaccine.2013.04.004

Negri, 2020, Attitudes towards influenza vaccine and a potential COVID-19 vaccine in Italy and differences across occupational groups, September 2020, Med. Lav., 111, 445

Gostin, 2020, The Dual Epidemics of COVID-19 and Influenza, JAMA, 324, 335, 10.1001/jama.2020.10802

Gerussi, V., Peghin, M., Palese, A., Bressan, V., Visintini, E., Bontempo, G., Graziano, E., De Martino, M., Isola, M., and Tascini, C. (2021). Vaccine Hesitancy among Italian Patients Recovered from COVID-19 Infection towards Influenza and Sars-Cov-2 Vaccination. Vaccines, 9.

Olanipekun, 2021, Attitudes and Perceptions Towards Coronavirus Disease 2019 (COVID-19) Vaccine Acceptance Among Recovered African American Patients, J. Gen. Intern. Med., 2021, 1

Sheikh, 2021, SARS-CoV-2 Delta VOC in Scotland: Demographics, risk of hospital admission, and vaccine effectiveness, Lancet, 397, 2461, 10.1016/S0140-6736(21)01358-1

Robert, M., Jason, H., and Czech, P.M. (2021, July 01). Names Fourth Health Minister Amid Sputnik Vaccine Strife. Reuters. Available online: https://www.reuters.com/article/us-czech-government/czech-pm-names-fourth-health-minister-amid-sputnik-vaccine-strife-idUSKBN2BU110.

(2021, July 01). Czech Civil Society Fights Back Against Fake News. DW. Available online: https://www.dw.com/en/czech-civil-society-fights-back-against-fake-news/a-53758412.

(2021, July 01). NELEŽ. Available online: https://www.nelez.cz/en/home-eng/.

(2021, July 01). Fakescape!. Available online: https://www.fakescape.cz/.

Hua, J., and Shaw, R. (2020). Corona Virus (COVID-19) “Infodemic” and Emerging Issues through a Data Lens: The Case of China. Int. J. Environ. Res. Public Health, 17.

Griffith, 2021, COVID-19 Vaccine Hesitancy in Canada: Content Analysis of Tweets Using the Theoretical Domains Framework, J. Med. Internet Res., 23, e26874, 10.2196/26874

Bonnevie, 2021, Quantifying the rise of vaccine opposition on Twitter during the COVID-19 pandemic, J. Commun. Health, 14, 12, 10.1080/17538068.2020.1858222

Riad, A., Pokorná, A., Attia, S., Klugarová, J., Koščík, M., and Klugar, M. (2021). Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic. J. Clin. Med., 10.

Riad, A., Sağıroğlu, D., Üstün, B., Pokorná, A., Klugarová, J., Attia, S., and Klugar, M. (2021). Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey. J. Clin. Med., 10.

Riad, A., Pokorná, A., Mekhemar, M., Conrad, J., Klugarová, J., Koščík, M., Klugar, M., and Attia, S. (2021). Safety of ChAdOx1 nCoV-19 Vaccine: Independent Evidence from Two EU States. Vaccines, 9.

Riad, A., Schünemann, H., Attia, S., Peričić, T., Žuljević, M., Jürisson, M., Kalda, R., Lang, K., Morankar, S., and Yesuf, E. (2021). COVID-19 Vaccines Safety Tracking (CoVaST): Protocol of a Multi-Center Prospective Cohort Study for Active Surveillance of COVID-19 Vaccines’ Side Effects. Int. J. Environ. Res. Public Health, 18.

Jęśkowiak, I., Wiatrak, B., Grosman-Dziewiszek, P., and Szeląg, A. (2021). The Incidence and Severity of Post-Vaccination Reactions after Vaccination against COVID-19. Vaccines, 9.

(2020). Collaborating in response to COVID-19: Editorial and methods initiatives across Cochrane. Collaborating in Response to COVID-19: Editorial and Methods Initiatives Across Cochrane, John Wiley & Sons, Inc.

Klugar, M., Riad, A., Mekhemar, M., Conrad, J., Buchbender, M., Howaldt, H.-P., and Attia, S. (2021). Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers. Biology, 10.

Eurostat (2021, July 01). International Standard Classification of Education (ISCED). Statistics Explained. Available online: https://ec.europa.eu/eurostat/statistics-explained/index.php?title=International_Standard_Classification_of_Education_(ISCED).

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Tập 9 Số 9

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