Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring

International Journal of Developmental Neuroscience - Tập 27 - Trang 525-530 - 2009
Vera Bubenikova-Valesova1, Petr Kacer2, Kamila Syslova2, Lukas Rambousek2, Martin Janovsky3, Barbora Schutova4, Lenka Hruba4, Romana Slamberova4
1Prague Psychiatric Center, Department of Biochemistry and Brain Pathophysiology, Ústavní 91, 181 03 Prague 8, Bohnice, Czech Republic
2Institute of Chemical Technology Prague, Faculty of Chemical Technology, Department of Organic Technology, Prague, Czech Republic
3Charles University in Prague, Third Faculty of Medicine, Department of Pharmacology, Prague, Czech Republic
4Charles University in Prague, Third Faculty of Medicine, Department of Normal, Pathological and Clinical Physiology, Prague, Czech Republic

Tóm tắt

AbstractMethamphetamine is a commonly abused psychostimulant that causes addiction and is often abused by pregnant women. Acute or chronic administration of methamphetamine elevates the levels of the extracellular monoamine neurotransmitters, such as dopamine.The aim of the present study was to show whether prenatal exposure to methamphetamine (5 mg/kg, entire gestation) or saline in Wistar rats induces changes in dopamine levels and its metabolites in the nucleus accumbens, and in behavior (locomotor activity, rearing, and immobility) after the administration of a challenge dose of methamphetamine (1 mg/kg) or saline in male offspring.We found that adult offspring prenatally exposed to methamphetamine had higher basal levels of dopamine (about 288%), dihydroxyphenylacetic acid (about 67%) and homovanillic acid (about 74%) in nucleus accumbens. An increased basal level of dopamine corresponds to lower basal immobility in offspring prenatally exposed to methamphetamine. The acute injection of methamphetamine in adulthood increased the level of dopamine in the nucleus accumbens, which is related to an increase of locomotion and rearing (exploration). In addition, prenatally methamphetamine‐exposed rats showed higher response to the challenge dose of methamphetamine, when compared to prenatally saline‐exposed rats.In conclusion, rats exposed to methamphetamine in utero have shown changes in the mesolimbic dopaminergic system and were more sensitive to the administration of the acute dose of methamphetamine in adulthood.

Tài liệu tham khảo

10.1212/WNL.42.3.683 10.1111/j.1651-2227.1996.tb13993.x 10.1016/j.pscychresns.2004.06.004 Dattel B.J., 1990, Substance abuse in pregnancy, Semin. Perinatal., 14, 179 10.1016/S0166-4328(02)00286-3 10.1016/0304-3940(80)90062-2 10.1111/j.1471-4159.2007.05142.x 10.1111/j.1749-6632.2002.tb04182.x Hellar A., 2001, Gender‐dependent enhanced adult neurotoxic response to methamphetamine following fetal exposure to the drug, J. Pharmacol. Exp. Ther., 298, 769 10.1002/dev.20346 10.1016/j.ejphar.2006.08.031 10.1503/cmaj.071675 10.1016/S0896-6273(00)80557-7 10.1007/s11373-007-9218-7 Landa L., 2005, Interspecies comparison of sensitization to methamphetamine effects on locomotion in mice and rats, Homeost. Health Dis., 43, 146 10.1016/j.neuroscience.2004.06.017 10.1196/annals.1441.024 Paxinos G., 2003, The Rat Brain in Stereotaxic Coordinates 10.1196/annals.1369.016 10.1016/0006-8993(91)91452-7 10.1016/0014-2999(76)90299-5 10.1016/S0889-8545(05)70361-2 Schutová B., 2008, Impact of methamphetamine administered prenatally and in adulthood on cognitive functions of male rats tested in Morris water maze, Prague Med. Rep., 109, 62 Segal D.S., 1997, Repeated binge exposures to amphetamine and methamphetamine: behavioral and neurochemical characterization, J. Pharmacol. Exp. Ther., 282, 561 10.1111/j.1749-6632.1996.tb17456.x Shoblock J.R., 2003, Neurochemical and behavioral differences between d‐methamphetamine and d‐amphetamine in rats, Psychopharmacology, 65, 359, 10.1007/s00213-002-1288-7 10.1016/j.reprotox.2004.11.010 10.1016/j.devbrainres.2005.04.005 10.1016/j.pnpbp.2005.06.006 10.1016/j.pneurobio.2005.04.003 10.1016/j.ejphar.2004.07.064 10.1111/j.1476-5381.1973.tb08341.x 10.1111/j.1600-0773.1996.tb00224.x Turner C.D., 1976, Endocrinology of the Ovary, 450 10.1111/j.1749-6632.2001.tb03560.x
Thông tin
Thông tin xuất bản

International Journal of Developmental Neuroscience

Tập 27

525-530

Thông tin tác giả