Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

Nature - Tập 515 Số 7528 - Trang 563-567 - 2014
Roy S. Herbst1, Jean‐Charles Soria2, Marcin Kowanetz3, Gregg Fine3, Omid Hamid4, Michael S. Gordon5, Jeffery A. Sosman6, David F. McDermott7, John D. Powderly8, Scott Gettinger1, Holbrook E. Kohrt9, Leora Horn10, Donald P. Lawrence11, Sandra Rost3, Maya Leabman3, Yuanyuan Xiao3, Ahmad Mokatrin3, Hartmut Koeppen3, Priti S. Hegde3, Ira Mellman3, Daniel S. Chen3, F. Stephen Hodi12
1Yale Comprehensive Cancer Center, Yale School of Medicine, 333 Cedar Street, WWW221, New Haven, Connecticut 06520, USA,
2Gustave Roussy South-Paris University, 114 Rue Edouard Vaillant, 94805 Villefuij, Cedex, France,
3Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
4The Angeles Clinic and Research Institute, 11818 Wilshire Blvd, Los Angeles, 90025, California, USA
5Pinnacle Oncology Hematology, 9055 E Del Camino Dr 100, Scottsdale, 85258, Arizona, USA
6Vanderbilt-Ingram Cancer Center, 2220 Pierce Avenue, Nashville, 37212, Tennessee, USA
7Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Shapiro 9, Boston, Massachusetts 02215, USA,
8Carolina BioOncology Institute, 9801 W. Kincey Ave, Suite 145, Huntersville, North Carolina 28078, USA,
9Stanford University, CCSR Bldg Room 1110, Stanford, 94305, California, USA
10Vanderbilt-Ingram Cancer Center, 1301 Medical Center Dr, Suite 1710, Nashville, Tennessee 37212, USA,
11Massachusetts General Hospital, 55 Fruit Street, YAW 9E, Boston, Massachusetts 02114, USA,
12Dana-Farber/Brigham and Women’s Cancer Center, 450 Brookline Avenue, Boston, 02215, Massachusetts, USA

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