Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport

EBioMedicine - Tập 24 - Trang 76-92 - 2017
Nadine Ruderisch1, Daniel Schlatter2, Andreas Kuglstatter2, Wolfgang Guba2, Sylwia Huber2, Carlo Cusulin2, Jörg Benz2, Arne Christian Rufer2, Joerg Hoernschemeyer2, Christophe Schweitzer1, Tina Bülau2, Achim Gärtner3, Eike Hoffmann3, Jens Niewoehner3, Christoph Patsch2, Karlheinz Baumann1, Hansruedi Loetscher1, Eric Kitas2, Per-Ola Freskgård1
1Pharma Research and Early Development (pRED), Neurodegeneration and Regeneration, Roche Innovation Center Basel, Switzerland
2Pharma Research and Early Development (pRED), Therapeutic Modalities, Roche Innovation Center Basel, Switzerland
3Pharma Research and Early Development (pRED), Therapeutic Modalities, Roche Innovation Center Munich, Germany

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