mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis

Cell Reports - Tập 15 - Trang 86-95 - 2016
Veronica Costa1, Stefan Aigner1, Mirko Vukcevic2, Evelyn Sauter1, Katharina Behr2, Martin Ebeling3, Tom Dunkley3, Arno Friedlein3, Sannah Zoffmann4, Claas A. Meyer4, Frédéric Knoflach1, Sebastian Lugert1, Christoph Patsch4, Fatiha Fjeldskaar1, Laurie Chicha-Gaudimier5, Anna Kiialainen3, Paolo Piraino6, Marc Bedoucha1, Martin Graf4, Sebastian Jessberger7
1Roche Pharmaceutical Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland
2Department of Biomedicine, University of Basel, Pestalozzistrasse 20, 4056 Basel, Switzerland
3Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland
4Roche Pharmaceutical Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland
5Department of Neurosurgery, Universitätsspital Basel, ZLF 20 Hebelstrasse, 4031 Basel, Switzerland
6Pvalue Research SRL, 29015 Castel San Giovanni, Italy
7Brain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, Switzerland

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