Poor Outcomes in Patients with Primary Malignant Mediastinal Germ‐cell Tumors

The Kaohsiung Journal of Medical Sciences - Tập 21 - Trang 561-565 - 2005
Hui-Hua Hsiao1, Yi-Chang Liu1, Hui-Jen Tsai1, Inn-Went Chong1, Won-Chi Yang1, Ta-Chi Liu1, Sheng-Fung Lin1
1Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

Tóm tắt

Primary mediastinal germ‐cell tumors (GCTs) without gonadal involvement are rare and can be divided into benign mature teratoma and malignant seminoma or nonseminoma. We describe our experience of malignant mediastinal GCTs and compare the presentations and outcome with those of benign teratomas. Four malignant GCTs (1 seminoma, 1 choriocarcinoma, and 2 yolk‐sac tumors) have been treated in our hospital. All patients were men with obvious symptoms before diagnosis. The patient with seminoma was treated with surgery and radiation, while those with nonseminoma tumors were treated with chemotherapy and/or surgery. Two patients died, one with extended pulmonary metastasis and the other with relapsed disease and high levels of tumor markers. Compared with the nine cases of benign teratomas, the four malignant GCTs showed overwhelming male dominance, advanced symptoms at presentation, and poor outcome. These cases highlight the important role of disease staging and tumor‐marker levels in malignant GCTs, and suggest that new treatment strategies for malignant GCTs await further investigation.

Tài liệu tham khảo

Cameron RB, 2001, Cancer: Principles and Practice of Oncology, 1028 Macciarini P, 2004, Uncommon primary mediastinal tumours, Lancet Oncol, 5, 107, 10.1016/S1470-2045(04)01385-3 10.1200/JCO.2002.07.062 10.1002/cncr.10738 10.1002/cncr.11068 10.1148/rg.242035082 10.1016/0002-9343(62)90167-5 10.1002/1097-0142(19900401)65:7<1641::AID-CNCR2820650731>3.0.CO;2-U 10.1002/(SICI)1097-0142(20000301)88:5<1051::AID-CNCR15>3.0.CO;2-R 10.1002/1097-0142(20010401)91:7<1394::AID-CNCR1144>3.0.CO;2-Y 10.1093/jjco/hyh062 Pectasides D, 1999, Platinum‐ based chemotherapy of primary extragonadal germ cell tumours: The Hellenic Cooperative Oncology Group experience, Oncology, 57, 1, 10.1159/000011993 10.1038/sj.bmt.1704704 10.1093/annonc/mdi017 Mostofi FK, 1977, International Histological Classification of Tumors, 137 Yaui H, 1999, Thoracic and cardiovascular surgery in Japan during 1997. Annual report by the Japanese Association for Thoracic Surgery, Jpn J Thorac Cardiovasc Surg, 47, 236 10.1016/S0022-5223(19)39090-7 10.1016/S0022-5223(19)38852-X 10.1002/1097-0142(19930915)72:6<1894::AID-CNCR2820720617>3.0.CO;2-6 Moran CA, 1997, Primary germ cell tumours of the mediastinum. Analysis of 322 cases with special emphasis on teratomatous lesions and a proposal for histopathologic classification and clinical staging, Cancer, 15, 681 10.1378/chest.99.2.472 10.1016/S0959-8049(97)10021-1 10.1002/1097-0142(19940401)73:7<1971::AID-CNCR2820730731>3.0.CO;2-A
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Thông tin xuất bản

The Kaohsiung Journal of Medical Sciences

Tập 21

561-565

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