Polycomb CBX7 Directly Controls Trimethylation of Histone H3 at Lysine 9 at the p16 Locus

A Merlo, 1995, 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers., Nat Med, 1, 686, 10.1038/nm0795-686

M Gonzalez-Zulueta, 1995, Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing., Cancer Res, 55, 4531

JG Herman, 1995, Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers., Cancer Res, 55, 4525

J Cao, 2009, Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study., Clin Cancer Res, 15, 5178, 10.1158/1078-0432.CCR-09-0580

J Gil, 2006, Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all., Nat Rev Mol Cell Biol, 7, 667, 10.1038/nrm1987

GN Maertens, 2009, Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus., PLoS One, 4, e6380, 10.1371/journal.pone.0006380

JJ Jacobs, 1999, The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus., Nature, 397, 164, 10.1038/16476

JA Simon, 2009, Mechanisms of polycomb gene silencing: knowns and unknowns., Nat Rev Mol Cell Biol, 10, 697, 10.1038/nrm2763

A Sparmann, 2006, Polycomb silencers control cell fate, development and cancer., Nat Rev Cancer, 6, 846, 10.1038/nrc1991

AP Bracken, 2007, The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells., Genes Dev, 21, 525, 10.1101/gad.415507

E Ezhkova, 2009, Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells., Cell, 136, 1122, 10.1016/j.cell.2008.12.043

E Vire, 2006, The Polycomb group protein EZH2 directly controls DNA methylation., Nature, 439, 871, 10.1038/nature04431

AJ Bannister, 2001, Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain., Nature, 410, 120, 10.1038/35065138

A Barski, 2007, High-resolution profiling of histone methylations in the human genome., Cell, 129, 823, 10.1016/j.cell.2007.05.009

M Lachner, 2001, Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins., Nature, 410, 116, 10.1038/35065132

E Bernstein, 2006, Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin., Mol Cell Biol, 26, 2560, 10.1128/MCB.26.7.2560-2569.2006

D O'Carroll, 2000, Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression., Mol Cell Biol, 20, 9423, 10.1128/MCB.20.24.9423-9433.2000

AH Peters, 2001, Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability., Cell, 107, 323, 10.1016/S0092-8674(01)00542-6

M Tachibana, 2002, G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis., Genes Dev, 16, 1779, 10.1101/gad.989402

J Gil, 2004, Polycomb CBX7 has a unifying role in cellular lifespan., Nat Cell Biol, 6, 67, 10.1038/ncb1077

D Bernard, 2005, CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus., Oncogene, 24, 5543, 10.1038/sj.onc.1208735

S Gonzalez, 2006, Oncogenic activity of Cdc6 through repression of the INK4/ARF locus., Nature, 440, 702, 10.1038/nature04585

C Vincenz, 2008, Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences., Proc Natl Acad Sci U S A, 105, 16572, 10.1073/pnas.0805317105

A Federico, 2009, Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein., Cancer Res, 69, 7079, 10.1158/0008-5472.CAN-09-1542

HP Mohammad, 2009, Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation., Cancer Res, 69, 6322, 10.1158/0008-5472.CAN-09-0065

B Zhang, 2008, Genetic polymorphisms of the E-cadherin promoter and risk of sporadic gastric carcinoma in Chinese populations., Cancer Epidemiol Biomarkers Prev, 17, 2402, 10.1158/1055-9965.EPI-08-0315

N Dietrich, 2007, Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus., Embo J, 26, 1637, 10.1038/sj.emboj.7601632

MA Hahn, 2008, Methylation of polycomb target genes in intestinal cancer is mediated by inflammation., Cancer Res, 68, 10280, 10.1158/0008-5472.CAN-08-1957

S Hinz, 2008, Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance., Tumour Biol, 29, 323, 10.1159/000170879

P Pallante, 2008, Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer., Cancer Res, 68, 6770, 10.1158/0008-5472.CAN-08-0695

CL Scott, 2007, Role of the chromobox protein CBX7 in lymphomagenesis., Proc Natl Acad Sci U S A, 104, 5389, 10.1073/pnas.0608721104

WJ Guo, 2007, Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells., Cancer Res, 67, 5083, 10.1158/0008-5472.CAN-06-4368

LP Eads C, 2002, Combined bisulfite restriction analysis (COBRA)., 53

D Luo, 2006, Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas., Lab Invest, 86, 591, 10.1038/labinvest.3700415

Y Shang, 2000, Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription., Cell, 103, 843, 10.1016/S0092-8674(00)00188-4