Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS): protocol for a randomized controlled trial

Michael Walsh1,2, Peter A. Merkel3, Chen Au Peh4, Wladimir Szpirt5, Loı̈c Guillevin6, Charles D. Pusey7, Janak Dezoysa8, Natalie Ives9, William F. Clark10, Karen Quillen11, Jeffrey L. Winters12, Keith Wheatley13, David Jayne14
1Departments of Medicine and Clinical Epidemiology & Biostatistics, Marian Wing, Division of Nephrology, McMaster University, St. Joseph's Hospital, Hamilton, Canada
2the PEXIVAS Investigators, UK
3Division of Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, USA
4Department of Renal Medicine, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
5Department of Nephrology, Copenhagen University Hospital, Copenhagen, Denmark
6Höpital Cochin, Assistance Publique, Hopitaux de Paris, Universite Paris Descartes, Paris, France
7Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK
8Department of Renal Medicine, North Shore Hospital, Waitemata District Health Board, Auckland, New Zealand
9Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK
10London Health Sciences Centre, Western University, London, Canada
11Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, USA
12Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, USA
13Cancer Research UK Clinical Trials Unit, School of Cancer Sciences, University of Birmingham, Birmingham, UK
14Lupus and Vasculitis Clinic, Addenbrooke's Hospital, Cambridge, UK

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