Pituitary metastases of Hürthle cell carcinoma of the thyroid
Tóm tắt
An 85-year-old man was referred to endocrinology following the discovery of an incidental pituitary mass on cranial imaging which was thought to be a non-functioning adenoma during an admission with headaches, lethargy, confusion and hyponatraemia. He had a history of Hürthle cell carcinoma of the thyroid treated with total thyroidectomy, ablative radioiodine therapy and thyroxine replacement. Subsequently, he developed metastatic spread to the neck, lungs and skeleton. About 9 months later, the patient had deterioration of vision. MRI showed a rapidly expanding pituitary mass with compression of the optic chiasm. Biochemical investigations confirmed hypocortisolism and hypogonadism. The patient underwent trans-sphenoidal resection of the pituitary mass followed by external beam radiotherapy to the pituitary bed. Histopathology confirmed a metastatic deposit of Hürthle cell carcinoma, which is a rare and aggressive variant of follicular thyroid carcinoma.
Từ khóa
Tài liệu tham khảo
Barbaro, 2013, Pituitary metastasis of thyroid cancer, Endocrine, 43, 485, 10.1007/s12020-012-9806-9
Souza Mota, 2018, Pituitary metastasis of thyroid carcinoma: a case report, Am J Case Rep, 19, 896, 10.12659/AJCR.909523
Matyja, 2013, Pituitary metastases from the oncocytic variant of follicular thyroid carcinoma: a case report and diagnostic dilemmas, Folia Neuropathol, 51, 261, 10.5114/fn.2013.37711
Nikiforov YE , Biddinger PW , Thompson LDR . Diagnostic pathology and molecular genetics of the thyroid: a comprehensive guide for practicing thyroid pathology. USA: Wolters Kluwer Health, 2012.
Guerrero, 2010, Age and tumor size predicts lymph node involvement in Hürthle cell carcinoma, J Cancer, 1, 23, 10.7150/jca.1.23
Bishop, 2012, Histological patterns of locoregional recurrence in Hürthle cell carcinoma of the thyroid gland, Thyroid, 22, 690, 10.1089/thy.2011.0407
Lim, 2015, Thyroid carcinoma with pituitary metastases: 2 case reports and literature review, Case Rep Endocrinol, 2015