Pituitary metastases of Hürthle cell carcinoma of the thyroid

BMJ Case Reports - Tập 14 Số 1 - Trang e239456 - 2021
Nosakhare Paul Ilerhunmwuwa1, Robert Goldspring2, Simon Page1, Ravikanth Gouni1
1Diabetes and Endocrinology, Queen's Medical Centre Nottingham University Hospital NHS Trust, Nottingham, UK
2Pathology, Queen's Medical Centre Nottingham University Hospital NHS Trust, Nottingham, UK

Tóm tắt

An 85-year-old man was referred to endocrinology following the discovery of an incidental pituitary mass on cranial imaging which was thought to be a non-functioning adenoma during an admission with headaches, lethargy, confusion and hyponatraemia. He had a history of Hürthle cell carcinoma of the thyroid treated with total thyroidectomy, ablative radioiodine therapy and thyroxine replacement. Subsequently, he developed metastatic spread to the neck, lungs and skeleton. About 9 months later, the patient had deterioration of vision. MRI showed a rapidly expanding pituitary mass with compression of the optic chiasm. Biochemical investigations confirmed hypocortisolism and hypogonadism. The patient underwent trans-sphenoidal resection of the pituitary mass followed by external beam radiotherapy to the pituitary bed. Histopathology confirmed a metastatic deposit of Hürthle cell carcinoma, which is a rare and aggressive variant of follicular thyroid carcinoma.

Từ khóa


Tài liệu tham khảo

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BMJ Case Reports

Tập 14 Số 1

e239456

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