Phytotherapy for Wound Healing: The Most Important Herbal Plants in Wound Healing Based on Iranian Ethnobotanical Documents
Tóm tắt
Wound healing is a process that starts with the inflammatory response after the occurrence of any damage. This process initiates by restoring the wound surface coating tissue, migrating fibroblasts to form the required collagen, forming a healing tissue and finally, leading to contortion and extraction of the wound. Today, various drugs are used to heal wounds. However, the drugs used to repair wounds have some defects and side effects. In spite of all attempts to accelerate wound healing definitely, no safe drug has been introduced for this purpose. Therefore, the necessity to identify herbal plants in ethnopharmacology and ethnobotany documents with healing effects is essential. In this article, we tried to review and present effective Iranian medicinal plants and herbal compounds used for wound healing. Searching was performed on databases, including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other databases. The keywords used included wound healing, skin treatment, medicinal plants, ethnobotany, and phytotherapy. In this regard, 139 medicinal plants effective on wound healing were identified based on ethnopharmacology and ethnobotanical sources of Iran. Plants such as Salvia officinalis, Echium amoenum, Verbascum spp., G1ycyrrhiza glabra, Medicago sativa, Mentha pulegium, Datura stramonium L., Alhagi spp., Aloe vera, Hypericum perforatum, Pistacia atlantica and Prosopis cineraria are the most important and useful medicinal plants used for wound healing in Iran. These native Iranian medicinal plants are rich in antioxidants and biological compounds and might be used for wound healing and preparation of new drugs.
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Johnston D.E.; Wound healing in skin, plastic and reconstructive surgery. Vet Clin North Am 1990,20(1),1-45
Souba W.W.; Wilmore D.; Diet and nutrition in case of the patient with surgery trauma and sepsis Modern nutrition in health and disease, 9th ed 1999,1589-1618
Schwartz S.; Principeles of surgery 4th ed Newyork: Mcgrawhill company 1984,289-304
Tian J.; Wong K.K.; Ho C.M.; Lok C.N.; Yu W.Y.; Che C.M.; Chiu J.F.; Tam P.K.; Topical delivery of silver nanoparticles promotes wound healing. ChemMedChem 2007,2(1),129-136
Léguillier T.; Lecsö-Bornet M.; Lémus C.; Rousseau-Ralliard D.; Lebouvier N.; Hnawia E.; Nour M.; Aalbersberg W.; Ghazi K.; Raharivelomanana P.; Rat P.; the wound healing and antibacterial activity of five ethnomedical calophyllum inophyllum oils: An alternative therapeutic strategy to treat infected wounds. PLoS One 2015,10(9)
Suba V.; Murugesan T.; Arunachalam G.; Mandal S.C.; Saha B.P.; Anti-diabetic potential of Barleria lupulina extract in rats. Phytomedicine 2004,11(2-3),202-205
Sewall G.K.; Robertson K.M.; Connor N.P.; Heisey D.M.; Hartig G.K.; Effect of topical mitomycin on skin wound contraction. Arch Facial Plast Surg 2003,5(1),59-62
Huong J.S.; wang YH, Ling TY, Chuang SS, Johnson FE, Huang SS: Synthelic TGF antagoniset accelerates wound healing and reduces scarring. FASEB J 2002,16,1269-1270
Hemmati A.A.; Arzi A.; Amin M.; Effect of Achillea millefolium extract in wound healing of rabbit. J Nat Rem 2002,2(2),164-167
Tramontina V.A.; Machado M.A.; Nogueira Filho, Gda.R.; Kim, S.H.; Vizzioli, M.R.; Toledo, Sd. Effect of bismuth subgallate (local hemostatic agent) on wound healing in rats. Histological and histometric findings. Braz Dent J 2002,13(1),11-16
Cheng C.L.; Koo M.W.L.; Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats. Life Sci 2000,67(21),2647-2653
Tiwari R.; Chakraborty S.; Dhama K.; Miracle of herbs in antibiotic resistant wounds and skin infections: Treasure of nature – a review/perspective. Pharma Sci Monitor 2013,4,214-248
Jain N, Pathak R, Sandhu SS. Practices in wound healing studies of plants. Evid Based Complement Alternat Med Thakur R12011
Hosseini Z.; Lorigooini Z.; Rafieian-Kopaei M.; Shirmardi H.A.; Solati K.; A review of botany and pharmacological effect and chemical composition of echinophora species growing in Iran. Pharmacol Res 2017,9(4),305-312
Bahmani M.; Sarrafchi A.; Shirzad H.; Asgari S.; Rafieian-Kopaei M.; Cardiovascular toxicity of cyclooxygenase inhibitors and promising natural substitutes. Curr Pharm Des 2017,23(6),952-960
Rouhi-Boroujeni H.; Heidarian E.; Rouhi-Boroujeni H.; Deris F.; Rafieian-Kopaei M.; Medicinal plants with multiple effects on cardiovascular diseases: A systematic review. Curr Pharm Des 2017,23(7),999-1015
Safa O.; Soltanipoor M.A.; Rastegar S.; Kazemi M.; Nourbakhsh Dehkordi K.; Ghannadi A.; An ethnobotanical survey on hormozgan province, Iran. Avicenna J Phytomed 2013,3(1),64-81
Dolatkhahi M.; Ghorbani-Nahouji M.; Mehr-Afarin A.; Amininejad GHR; Dolatkhahi, A An Ethnobotanical Study of Medicinal Plants city Kazeroon: Identification, distribution and use of traditional. J Med Plants 2012,11(2),163-178
Dolatkhahi M.; Dolatkhahi A.; Nejad J.B.; Ethnobotanical study of medicinal plants used in Arjan - Parishan protected area in Fars Province of Iran. Avicenna J Phytomed 2014,4(6),402-412
Amiri M.S.; Jabbarzadeh P.; Akhondi M.; An ethnobotanical survey of medicinal plants used by indigenous people in Zangelanlo district. Northeast Iran J Med Plants Res 2016,6(5),749-753
Zolfaghari B.; sadeghi M, Tiri I, Yousefalitabar M: Collect, identify and review traditional uses of plants from Babol. J Tradit Med Islam Iran 2012,3(1),113-122
Iranmanesh M.; Najafi S.H.; Yosefi M.; Studies on Ethnobotany of important medicinal plants in Sistan. J Herbal Drugs 2010,1(2),58-65
Ghasemi Pirbalouti A.; Momeni M.; Bahmani M.; Ethnobotanical study of medicinal plants used by Kurd tribe in Dehloran and Abdanan Districts, Ilam Province, Iran. Afr J Tradit Complement Altern Med 2012,10(2),368-385
Mosaddegh M.; Naghibi F.; Moazzeni H.; Pirani A.; Esmaeili S.; Ethnobotanical survey of herbal remedies traditionally used in Kohghiluyeh va Boyer Ahmad province of Iran. J Ethnopharmacol 2012,141(1),80-95
Mohammadi H.; Sajjadi S.E.; Noroozi M.; Mirhosseini M.; Collection and assessment of traditional medicinal plants used by the indigenous people of Dastena in Iran. J Herbmed Pharmacol 2016,5(2),54-60
Amiri M.S.; Joharchi M.R.; Ethnobotanical investigation of traditional medicinal plants commercialized in the markets of Mashhad, Iran. Avicenna J Phytomed 2013,3(3),254-271
Miraldi E.; Ferri S.; Mostaghimi V.; Botanical drugs and preparations in the traditional medicine of West Azerbaijan (Iran). J Ethnopharmacol 2001,75(2-3),77-87
Khodayari H.; Amani SH; Amiri, H Ethnobotanical study of North east of Khuzistan province. Med Plants Ecophytochem J 2013,2(4),12-26
Rajaei P.; Mohamadi N.; Ethnobotanical study of medicinal plants of hezar mountain allocated in South East of iran. Iran J Pharm Res 2012,11(4),1153-1167
Tahvilian R.; Shahriari S.; Faramarzi A.; Komasi A.; ethno-pharmaceutical formulations in kurdish ethno-medicine. Iran J Pharm Res 2014,13(3),1029-1039
Sharififar F; Koohpayeh A Motaghi MM; Amirkhosravi A; Puormohseni Nasab E; Khodashenas, M Study the ethnobotany of medicinal plants in Sirjan, Kerman province, Iran J Herb drugs, 2010,1(3),19-28
Zolfeghari E.; Adeli I.; Mozafarian V.; Babaiy S.; Habibi Bibalan G.H.; Identification of Arasbaran medicinal plants and ethnobotanical study of rural people knowledge (Case Study: Arasbaran forest, Mardanaghom watershed). Tahqiqat-i Giyahan-i Daruyi va Muattar-i Iran 2012,28(3),534-550
Sharififar F.; MoharamKhani MR, Moattar F, Babakhanloo P, Khodami M: Ethnobotanical study of medicinal plants of Joopar mountians of Kerman province, Iran. Kernan Uni Med Sci J 2012,21(1),37-51
Naghibi F.; Esmaeili S.; Malekmohammadi M.; Hassanpour A.; Mosaddegh M.; Ethnobotanical survey of medicinal plants used traditionally in two villages of Hamedan, Iran. Avicenna J Phytomed 2014,1(3),7-14
Razmjoei D.; Zarei Z.; Akbari M.; Study of ethnobotany of some medicinal plants in Abadeh, Fars Province. J. Eco-physiol. Agricult Plants 2015,7(3),222-234
Ghasemi-Dehkordi N.; Nourouzi M and safaei-Aziz A: Collection and review of traditional uses of Jandag plants. J Tradit Med Islam Iran 2012,3(1),105-112
Vakili Shahrbabaki S.M.A.; The Ethnobotanical study of medicinal plants in (dehe-lolo-vameghabadbidoieh) village. Kerman, Iran. J Med Plants By-Prod 2016,1,105-111
Mosaddegh M.; Esmaeili S.; Hassanpour A.; Malekmohammadi M.; Naghibi F.; Ethnobotanical study in the highland of Alvand and Tuyserkan, Iran. Res JPharmacog [RJP]2016,3(1),7-17
Sajadi S.E.; batouli H and Ghanbari A: Collection and evaluation of the traditional selection of medicinal plants in Kashan. J Tradit Med Islam Iran 2011,2(1),29-36
Shahid S.; Kashmiri M.A.; Ahmad Adnan, Badawy Ali. chemical constituents, proximate composition and hepatoprotective activity of Abutilon muticum. Asian J Chem 2012,24(3),1179
Lacaille-Dubois M.A.; Hanquet B.; Rustaiyan A.; Wagner H.; Squarroside A, a biologically active triterpene saponin from Acanthophyllum squarrosum. Phytochemistry 1993,34(2),489-495
Csupor-Löffler B.; Hajdú Z.; Zupkó I.; Réthy B.; Falkay G.; Forgo P.; Hohmann J.; Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines. Phytother Res 2009,23(5),672-676
Khushbaktova ZA; Syrov VN; Kuliev Z; The effect of proanthocyanidins from Alhagi pseudoalhagi. Desv on course of experimental myocardial infarct. EKSP Klin Farmakol 1992,55(6),19-21
Singh V.P.; Yadav B.; Pandey V.B.; Flavanone glycosides from Alhagi pseudalhagi. Phytochemistry 1999,51(4),587-590
Zhang X.F.; Wang H.M.; Song Y.L.; Nie L.H.; Wang L.F.; Liu B.; Shen P.P.; Liu Y.; Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera. Bioorg Med Chem Lett 2006,16(4),949-953
Amanzadeh Y.; Hajimehdipoor H.; Abedi Z.; Khatamsaz M.; Chemical constituents of Amygdalus spp. oil from Iran. Res J Pharmacog 2016,3(1),29-33
Ping-Chung Kuo; Yue-Chiun Li; Tian-Shung Wu.; Chemical constituents and pharmacology of the Aristolochia species. J Tradit Complement Med 2012,2(4),249-266
Timothy C.; Birdsall N.D.; Gregory S.; Kelly N.D.; Berberine: Therapeutic potential of an alkaloid found in several medicinal plants. Altern Med Rev 2012,2(2),94-103
Mroczek A.; Kapusta I.; Janda B.; Janiszowska W.; Triterpene saponin content in the roots of red beet (Beta vulgaris L.) cultivars. J Agric Food Chem 2012,60(50),12397-12402
Arifkhodzhaev A.; Arifkhodzhaev K.; Khondratenko S.; Isolation and characterization of polysaccharides from Biebersteinia multifida. Khims Prir Soedin 1996,16,755-757
Sanei-Dehkordi A.; Vatandost H.; Abaei M.R.; Davari B.; Sedaghat M.M.; Chemical composition and larvicidal activity of bunium persicum essential oil against two important mosquitoes vectors. J Essential Oil Bearing Plants 2016,19(2),349-357
Cavalcante G.S.; de Morais S.M.; Andre W.P.; Ribeiro W.L.; Rodrigues A.L.; De Lira F.C.; Viana J.M.; Bevilaqua C.M.; Chemical composition and in vitro activity of Calotropis procera (Ait.) latex on Haemonchus contortus. Vet Parasitol 2016,226(226),22-25
Grosso C.; Juliana Vinholes; Luís R. Silva, Paula Guedes de Pinho, Rui F. Gonçalves; Patrícia Valentão, Anna K. Jäger, Paula B. Andrade. Chemical composition and biological screening of Capsella bursa-pastoris. Rev Bras Farmacogn 2011,21(4),635-644
Yasaukawa K.; Akihisa T.; Kaminaga T.; Kanno H.; Kumaki K.; Tamura T.; Inhibitory effects of alkane-6-8- Diols, the components of Safflower on tumor promotion in two stage carcinogenesis. Oncology 1996,53,133-136
Salaberría F.; Constenla D.; Carelli A.A.; Carrín M.E.; Chemical Composition and Physical Properties of High Oleic Safflower Oils (Carthamus tinctorius, Var. CW88-OL and CW99-OL). J Am Oil Chem Soc 2016,93(10),1383-1391
Dayeni M.; Omidbaigi R.; Essential Oil content and constituents of Cercis siliquastrum L. Growing in Iran. J Essential Oil-bearing Plants JEOP 2013,9(2),140-143
Chawech R.; Dhekra Mhalla, Mohamed Trigui, Mohamed Mihoubi, Nicolas Fabre, Raoudha Jarraya. Chemical composition and antibacterial activity of extracts and compounds isolated from Citrullus colocynthis (L.). Schrad J Pharmacog Phytochem 2015,4(4),197-203
Tavakol afshari J.; Rakhshandeh H.; Zamani A.; Mahdavi Shahri N.; Ghazizadeh L.; Nourouzi M.; Cytotoxicity effects of citrullus colocynthis on hep2 and l929 cell lines Hakim 2005,8(2),47-54
Khori V.; Naebpour M.; Rakhshan E.; MirAbbasi A, Zamani M. The effect of essence of Citrus aurantium on the electrophysiological properties of isolated perfused rabbit AVnode. J. Gorgan. Uni Med Sci 2006,8(2),1-7
Liu H.L.; Liu B.L.; Wang G.C.; Dai Y.; Ye W.C.; Li Y.L.; Studies on the chemical constituents from Conyza canadensis. Zhong Yao Cai 2011,34(5),718-720
Khanahmadi M.; Miraghaee S.Sh.; Karimi I.; Evaluation of the Antioxidant and antimicrobial Properties of Dorema aucheri plant. Iran Red Crescent Med J 2012,14(10),684-685
Morteza-Semnani K.; Saeedi M.; Akbarzadeh M.; Chemical composition and antimicrobial activity of essential oil of Echium Italicum L. J. Essential Oil Bearing Plants 2013,12(5),557-561
Rojhan M.S.; Treatment with medicinal herbs 2003,98-99
Akhlaghi H.; Chemical composition of the essential oil from aerial parts of eremostachys macrophylla montbr.
The chemical constituents and economic plants of the Euphorbiaceae. Bot J Linn Soc ABDEL-FATTAH M. RIZK1987,94(1-2),293-326
Ko W.C.; Sheu J.R.; Tzeng S.H.; Chen C.M.; The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats. Planta Med 1998,64(3),229-232
Kavoosi G.; Rowshan V.; Chemical composition, antioxidant and antimicrobial activities of essential oil obtained from Ferula assa-foetida oleo-gum-resin: Effect of collection time. Food Chem 2013,138(4),2180-7
Oussalah M.; Caillet S.; Saucier L.; Lacroix M.; Inhibitory effects of selected plant essential oils on the growth of four pathogenic bacteria: E. coli O157:H7, S. typhimurium, S. aureus and Listeria monocytogenes. Food Control 2007,18(5),414-420
Helsper JF; Bücking M.; Muresan S.; Blaas J.; Wietsma WA; Identification of the volatile component(s) causing the characteristic foxy odor in various cultivars of Fritillaria imperialis L. (Liliaceae). J Agric Food Chem 2006
Suan R.; Alkaloids from Fumaria sepium and Fumaria agaria. Biochem Syst Ecol 2003,30,263-265
Ramona P.; Toiu A.J.N.; Wauters, Gianina Crişan. Phytochemical analysis of fumaria officinalis L. (Fumariaceae). Farmacia 2016,64(3),1
Zhao C.; Shao J.; Cao D.; Zhang Y.; Li X.; Chemical constituents of Galium verum. Zhongguo Zhongyao Zazhi 2009,34(21),2761-2764
Fuster V.; Alexander R.W.; O’Rourke R.A.; Roberts R.; King S.B.; Prystowsky E.N.; Hurst’s the heart 2001,Vol. 2,1065
Blumenthal M.; Goldberg A.; Brinckmann, J Herbal Medicine, Expanded Commission E Monographs 2000,233-235
Farhang H.R.; Mohammad Reza Vahabi; Ali Reza Allafchian. Chemical compositions of the essential oil of Gundelia tournefortii L. (Asteraceae) from Central Zagros, Iran. J Herbal Drugs 2016,6(4),227-233
Barnes J.; Anderson L.A.; Phillipson J.D.; St John’s wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J Pharm Pharmacol 2001,53(5),583-600
Cheriet T.; Mancini I.; Seghiri R.; Benayache F.; Benayache S.; Chemical constituents and biological activities of the genus Linaria (Scrophulariaceae). Nat Prod Res 2015,29(17),1589-1613
Hosseinian F.S.; Muir A.D.; Westcott N.D.; Krol E.S.; AAPH-mediated antioxidant reactions of secoisolariciresinol and SDG. Org Biomol Chem 2007,5(4),644-654
Dahech I.; Farah W.; Trigui M.; Ben Hssouna A.; Belghith H.; Belghith K.S.; Ben Abdallah F.; Antioxidant and antimicrobial activities of Lycium shawii fruits extract. Int J Biol Macromol 2013,60,328-333
Manayi A.; Saeidnia S.; Ostad S.N.; Hadjiakhoondi A.; Ardekani M.R.; Vazirian M.; Akhtar Y.; Khanavi M.; Chemical constituents and cytotoxic effect of the main compounds of Lythrum salicaria L. Z Natforsch C J Biosci 2013,68(9-10),367-375
Shahidivagheidahande F.; Study of phytochemical and antimicrobial effects of Mentha pulegium [dissertation] Tehran Univ 1987
Dehkordi N.; Iranian Herbal Pharmacopoeia Tehran 2003,206-11
Al-Shehbaz ; Ihsan A.; Price, Robert A. Delimitation of the Genus Nasturtium (Brassicaceae). Novon 1998,8(2),124-126
Derwich E.; Benziane Z.; Boukir A.; Antibacterial activity and chemical composition of the essential oil from flowers of Nerium oleander. Electronic J Environ Agricult Food Chem 2010,9(6),5
Chiang L.C.; Ng L.T.; Cheng P.W.; Chiang W.; Lin C.C.; Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clin Exp Pharmacol Physiol 2005,32(10),811-816
Sajjadi S.E.; Analysis of the essential oils of two cultivated basil (Ocimum basilicum L.) from Iran. Daru 2006,14,128-130
Telci I.; Bayram E.; Yilmaz G.; Avci B.; Variability in essential oil composition of Turkish basils (Ocimum basilicum L.). Biochem Syst Ecol 2006,34,489-497
Lahmar I.; Belghith H.; Ben Abdallah F.; Belghith K.; Nutritional Composition and phytochemical, antioxidative, and antifungal activities of Pergularia tomentosa L. BioMed Res Int 2017,2017
Rezaie M.; Farhoosh R.; Sharif A.; Asili J.; Iranshahi M.; Chemical composition, antioxidant and antibacterial properties of Bene (Pistacia atlantica subsp. mutica) hull essential oil. J Food Sci Technol 2015,52(10),6784-6790
Mirzaei A.; Mohammadi J.; Mirzaei N.; Mirzaei M.; The antioxidant capacities and total phenolic contents of some Medicinal Plants in Iran. J Fasa Univ Med Sci 2011,1(3),160-167
Nejati V.; Khaneshi F.; Effect of hydro-alcoholic extract of Plantago major leaf on serum level of insulin, glucose, and histology of pancreas and kidney in Streptozotocin-induced diabetic rats. Qom Univ Med Sci J 2013,7(5),14-20
Bajer T.; Janda V.; Bajerová P.; Kremr D.; Eisner A.; Ventura K.; Chemical composition of essential oils from plantago lanceolata L. leaves extracted by hydrodistillation. J Food Sci Technol 2016,53(3),1576-1584
Beara I.N.; Lesjak M.M.; Orcic D.Z.; Simin N.D.; Cetojevic-Simin D.D.; Bozin B.N.; Mimica-Dukic N.M.; Comparative analysis of phenolic profile, antioxidant, anti-inflammatory and cytotoxic activity of two closely-related plantain species: Plantago altissima L. and plantago lanceolata L. Lebensm Wiss Technol 2012,47,64-70
The traditional uses, chemical constituents and biological activities of Plantago major L. A review. J Ethnopharmacol Anne BeritSamuelsen2000,71(1-2),1-21
Zargari A.; Medicinal plants; Vol 1 1986
Akhonzadeh S.; Encyclopedia of Iranian medicinal Plants 2000,Vol. 1,115
Simopoulos A.P.; Norman H.A.; Gillaspy J.E.; Duke J.A.; Common Purslane a souree of Omega 3- fatty asids and antioxidants. J Ethnopharmacol 1998,22,33-44
Sachdeva S.; Kaushik V.; Saini V.; A Review on phytochemical and pharmacological potential of prosopis cineraria. Intl J Ethnobiol Ethnomed 2014,1(1),1-4
Marles R.J.; Farnsworth N.R.; Antidiabetic plants and their active constituents. Phytomedicine 1996; 2(2), 137- 89. Sarrafchi A, Bahmani M, Shirzad H, Rafieian-Kopaei M. Oxidative stress and parkinson’s disease: New hopes in treatment with herbal antioxidants. Curr Pharm Des 2016,22(2),238-246
Ansari nik H, Saberi M, Jahantigh M, Ebrahimzadeh A: The evaluation of chemical composition and dry matter degradability of prosopis farcta fruit using in situ nylon bag technique. Int J Agric Crop Sci 2013,5(9),972-975
Shrestha S.; Kaushik V.S.; Eshwarappa R.S.; Subaramaihha S.R.; Ramanna L.M.; Lakkappa D.B.; Pharmacognostic studies of insect gall of Quercus infectoria Olivier (Fagaceae). Asian Pac J Trop Biomed 2014,4(1),35-39
Kossah R.; Nsabimana C.; Zhao J.; Chen H.; Tian F.; Zhang H.; Chen W.; comparative study on the chemical composition of Syrian Sumac (Rhus coriaria L.) and Chinese Sumac (Rhus typhina L.). Fruits Pak J Nutr 2009,8,1570-1574
Günaydin K.; Topçu G.; Ion R.M.; 1,5-dihydroxyanthraquinones and an anthrone from roots of Rumex crispus. Nat Prod Lett 2002,16(1),65-70
Gohari A.R.; Ebrahimi H.; Saeidnia S.; Foruzani M.; Ebrahimi P.; Ajani Y.; flavones and flavone glycosides from Salvia macrosiphon Boiss. Iran J Pharm Res 2011,10(2),247-251
Zomorodian K.; Moein M.; Pakshir K.; Karami F.; Sabahi Z.; Chemical composition and antimicrobial activities of the essential oil from salvia mirzayanii Leaves. J Evid Based Complementary Altern Med 2017,22(4),770-776
Then M.; Lemberkovics E.; Marczal G.; Szentmihályi K.; Szöke E.; Plant anatomical and phytochemical evaluation of Salvia species. Acta Pharm Hung 1998,68(3),163-174
Carol A; Linda A; Anderson J; Philipson, D Herbal medicines 1996,231-232
Esmaeili A.; Masoudi Sh.; Masnabadi N.; Rustaiyan A.H.; Chemical constituents of the essential oil of Sanguisorba minor Scop. Leaves, from Iran. Faslnamah-i Giyahan-i Daruyi 2010,9(35),67-70
Kokubun T.; Harborne J.B.; Eagles J.; 2′, 6′-Dihydroxy-4′-methoxyacetophenone, a phytoalexin from the roots of Sanguisorba minor. Phytochemistry 1994,35(2),331-333
Pavlovic M.; Kovacevic N.; Tzakova O.; Couladis M.; Essential oil composition of Sanicula europaea L. Flavour Fragrance J 2006,21(4),687-689
Ahmed B.; Al-Rehaily A.J.; Al-Howiriny T.A.; El-Sayed K.A.; Ahmad M.S.; Scropolioside-D2 and harpagoside-B: Two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity. Biol Pharm Bull 2003,26(4),462-467
Babri S.H.; Doosti M.; Fatehi L.; Salari A.; The effects of Scrophularia striata extract on anxiety and depression behaviors in adult male mice. J Pharm Sci 2012,18(2),133-140
Bahrami A.; The effectiveness of Scrophularia striata on Newcastle disease. Aust J Basic Appl Sci 2011,5(12),2883-2888
Bodoira R.; Velez A.; Andreatta A.E.; Martínez M.; Maestri D.; Extraction of bioactive compounds from sesame (Sesamum indicum L.) defatted seeds using water and ethanol under sub-critical conditions. Food Chem 2017,237,114-120
Huang HC; Syu KY; Lin, JK Chemical composition of Solanum nigrum linn extract and induction of autophagy by leaf water extract and its major flavonoids in AU565 breast cancer cells J Agric Food Chem 2010
Ogalesyan G.B.; Galstyan A.M.; Mnatsakanyan V.A.; Shashkov A.S.; Agababyan P.V.; Phenylpropanoid glycosides of teucrium polium. Chem Nat Compd 1999,27,90-95
Abrurjari T.; Hadaib M.; Cavrini V.; Composition of the essential oil from Jordanian germander (Teucvium poliuml). J Essent Oil Res 2008,18,97-99
Purnavab S.; Ketabchi S.; Rowshan V.; Chemical composition and antibacterial activity of methanolic extract and essential oil of Iranian Teucrium polium against some of phytobacteria. Nat Prod Res 2015,29(14),1376-1379
Sareedenchai V.; Zidorn C.; Flavonoids as chemosystematic markers in the tribe Cichorieae of the Asteraceae. Biochem Syst Ecol 2010,38(5),935-957
Kroschewsky J.R.; Mabry T.J.; Markham K.R.; Alston R.E.; Flavonoids from the genus tragopogon (compositae). Phytochemistry 1996,8(8),1495-1498
Liu Y.F.; Yang X.W.; Wu B.; Studies on chemical constituents in the buds of Tussilago farfara. Zhongguo Zhongyao Zazhi 2007,32(22),2378-2381
McKenna DJ; Janes K; Hughes K; Botanical medicine: The desk reference for major herbal supplements ,1007-31
Mahmoudvand H.; Mirbadie S.R.; Fasihi Hardani M.; jahanbakhsh S, Saedi Dezaki E. Chemical composition and scolicidal activity of Zataria multiflora Boiss essential oil. J Essent Oil Res 2017,29(1),42-47
Ikram M.; Tomlinson H.; Chemical constituents of Zizyphus spina christi. Planta Med 1976,29(3),289-290
Caceres A.I.; Liu B.; Jabba S.V.; Achanta S.; Morris J.B.; Jordt S.E.; Transient receptor potential cation channel subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol. Br J Pharmacol 2017,174(9),867-879
Rocha Caldas G.F.; Oliveira A.R.; Araújo A.V.; Lafayette S.S.; Albuquerque G.S.; Silva-Neto, Jda.C.; Costa-Silva, J.H.; Ferreira, F.; Costa, J.G.; Wanderley, A.G. Gastroprotective Mechanisms of the Monoterpene 1,8-Cineole (Eucalyptol). PLoS One 2015,10(8)
Pan L.R.; Tang Q.; Fu Q.; Hu B.R.; Xiang J.Z.; Qian J.Q.; Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice. Acta Pharmacol Sin 2005,26(11),1334-1338
Shen L.; Cui Z.; Lin Y.; Wang S.; Zheng D.; Tan Q.; Anti-inflammative effect of glycyrrhizin on rat thermal injury via inhibition of high-mobility group box 1 protein. Burns 2015,41(2),372-378
Wruck C.J.; Claussen M.; Fuhrmann G.; Römer L.; Schulz A.; Pufe T.; Waetzig V.; Peipp M.; Herdegen T.; Götz M.E.; Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway. J Neural Transm Suppl 2007,72(72),57-67
Gomathi K; Gopinath D; Rafiuddin M; Ahmed R; Quercetin incorporated collagen matrices for dermal wound healing processes in rat. Biomaterials 2003,24(16),2767-2772
Chung K.T.; Wong T.Y.; Wei C.I.; Huang Y.W.; Lin Y.; Tannins and human health: A review. Crit Rev Food Sci Nutr 1998,38(6),421-464
Zanoli P.; Role of hyperforin in the pharmacological activities of St. John’s Wort. CNS Drug Rev 2004,10(3),203-218
Sayar H.; Gergerlioglu N.; Seringec N.; Ozturk P.; Bulbuloglu E.; Karabay G.; Comparison of efficacy of topical phenytoin with hypericin in second-degree burn wound healing: An experimental study in rats. Med Sci Monit Basic Res 2014,20,36-46
Galeotti N.; Di Cesare Mannelli L.; Mazzanti G.; Bartolini A.; Ghelardini C.; Menthol: A natural analgesic compound. Neurosci Lett 2002,322(3),145-148
Sabzghabaee A.M.; Nili F.; Ghannadi A.; Eizadi-Mood N.; Anvari M.; Role of menthol in treatment of candidial napkin dermatitis. World J Pediatr 2011,7(2),167-170
Mehmet Y.; Gunal, Aylin O. Heper and Nezahat Zaloglu. The effects of topical carvacrol application on wound healing process in male rats. Phcog J 2014,6(3),10-14
Salehi B.; Mishra A.P.; Shukla I.; Sharifi-Rad M.; Contreras M.D.M.; Segura-Carretero A.; Fathi H.; Nasrabadi N.N.; Kobarfard F.; Sharifi-Rad J.; Thymol, thyme, and other plant sources: Health and potential uses. Phytother Res 2018,32(9),1688-1706
Calderón-Montaño J.M.; Burgos-Morón E.; Pérez-Guerrero C.; López-Lázaro M.; A review on the dietary flavonoid kaempferol. Mini Rev Med Chem 2011,11(4),298-344
Özay Y.; Güzel S.; Yumrutaş Ö.; Pehlivanoğlu B.; Erdoğdu İ.H.; Yildirim Z.; Türk B.A.; Darcan S.; Wound healing effect of kaempferol in diabetic and nondiabetic rats. J Surg Res 2019,233,284-296
Aggarwal B.B.; Sundaram C.; Malani N.; Ichikawa H.; Curcumin: the Indian solid gold. Adv Exp Med Biol 2007,595,1-75
Akbik D.; Ghadiri M.; Chrzanowski W.; Rohanizadeh R.; Curcumin as a wound healing agent. Life Sci 2014,116(1),1-7
Vigani A.; Culler C.A.; Systemic and Local Management of Burn Wounds. Vet Clin North Am Small Anim Pract 2017,47(6),1149-1163
Shayganni E.; Bahmani M.; Asgary S.; Rafieian-Kopaei M.; Inflammaging and cardiovascular disease: Management by medicinal plants. Phytomedicine 2016,23(11),1119-1126
Priya K.S.; Arumugam G.; Rathinam B.; Wells A.; Babu M.; Celosia argentea Linn. leaf extract improves wound healing in a rat burn wound model. Wound Repair Regen 2004,12(6),618-625
Gholami-Ahangaran M.; Ahmadi-Dastgerdi A.; Karimi-Dehkordi M.; Thymol and carvacrol; as antibiotic alternative in green healthy poultry production. Plant Biotechnol Persa 2020,2(1),22-25
Mahdavi B.; Saneei S.; Qorbani M.; Zhaleh M.; Zangeneh A.; Zangeneh M.M.; Pirabbasi E.; Abbasi N.; Ghaneialvar H.; Ziziphora clinopodioides Lam leaves aqueous extract mediated synthesis of zinc nanoparticles and their antibacterial, antifungal, cytotoxicity, antioxidant, and cutaneous wound healing properties under in vitro and in vivo conditions. Appl Organomet Chem 2019,33(11)
Abassi N.; Ghaneialvar H.; Shahsavari S.; Natural remedies effective on stomachache in traditional medicine. Plant Biotechnol Persa 2020,2(1),42-47
Zangeneh M.M.; Ghaneialvar H.; Akbaribazm M.; Ghanimatdan M.; Abbasi N.; Goorani S.; Pirabbasi E.; Zangeneh A.; Novel synthesis of Falcaria vulgaris leaf extract conjugated copper nanoparticles with potent cytotoxicity, antioxidant, antifungal, antibacterial, and cutaneous wound healing activities under in vitro and in vivo condition. J Photochem Photobiol B 2019
Elyasi H.; Rahimi H.; Nafari A.; effects of genetically modified corn on human health. Plant Biotechnol Persa 2020,2(1),48-54
Bahmani M.; Taherikalani M.; Khaksarian M.; Rafieian-Kopaei M.; Ashrafi B.; Nazer M.; Soroush S.; Abbasi N.; Rashidipour M.; The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus. Future Sci OA 2019,5(3)
Eftekhari Z.; Antimicrobial properties of medicinal plants; The new therapeutic aspect of Valeriana officinalis. Plant Biotechnol Persa 2020,2(1),59-60
Abbasi N.; Khosravi A.; Aidy A.; Shafiei M.; Biphasic response to luteolin in MG-63 osteoblast-like cells under high glucose-induced oxidative stress. Iran J Med Sci 2016,41(2),118-125
Karimi E.; Alzheimer’s: Phytotherapy and the most important herbs in the treatment of Alzheimer’s. Plant Biotechnol Persa 2020,2(1),61-62
Valadi A.; Nasri S.; Abbasi N.; Amin G.R.; Antinociceptive and anti-inflammatory effects of hydroalchoholic extract of Anethum graveolens L. seed. Faslnamah-i Giyahan-i Daruyi 2010,9(34),124-130
Beiranvand F.; Alizadeh M.; Plants for remedies of diabetes mellitus in Iran. Plant Biotechnol Persa 2019,1(1),36-38
Moayeri A.; Azimi M.; Karimi E.; Aidy A.; Abbasi N.; Attenuation of morphine withdrawal syndrome by prosopis farcta extract and its bioactive component luteolin in comparison with clonidine in rats. Med Sci Monit Basic Res 2018,24(9),151-158
Alizadeh M.; Safarzadeh A.; Bahmani M.; beyranvand F, Mohammadi M, Azarbaijani K, Rafieian-Kopaei M, Abbaszadeh S. Brucellosis: Pathophysiology and new promising treatments with medicinal plants and natural antioxidants. Asian Pac J Trop Med 2018,11(11),597-608
F. Magbool F. formulation design, development and evaluation of quercus infectoria galls extract oral geLS. Plant Biotechnol Persa 2020,2(2),1-13