Phase III clinical trials of the cell differentiation agent-2 (CDA-2): Therapeutic efficacy on breast cancer, non-small cell lung cancer and primary hepatoma1

Chinese Journal of Clinical Oncology - Tập 2 Số 4 - Trang 706-716 - 2005
Feng-yi Feng1, Qing Li1, Changquan Ling2, Yang Zhang3, Fengzhan Qin4, Huaqing Wang5, Wenxia Huang6, Shunchang Jiao7, Qiang Chen8, Mingzhong Li9, Yunzhong Zhu10, Meizhen Zhou11, Jun Ren12, Gao Ye-tao2, Jingpo Zhao3, Rongqin Zheng4, Wenhua Zhao5, Zhiqiang Meng6, Fang Li7, Qizhong Zhang8, Dongfang Zhao9, Li‐Yan Xu10, Yongqiang Zhang11, Yanjun Zhang12, Zhenjiu Wang13, Shuanqi Liu13, Ming C. Liau14
1The Cancer Hospital of the Chinese Academy of Medical Science, 100021, Beijing, China
2Changhai Hospital of the Second Army Medical University, 200433, Shanghai, China
3The Second Affiliated Hospital of Dalian Medical University, 116027, Dalian, China
4The Cancer Hospital of Bengbu Medical College, 233004, Bengbu, China
5The Cancer Hospital of Tianjin Medical University, 300060, Tianjin, China
6The Affiliated Cancer Hospital of Fudan Medical University, 200032, Shanghai, China
7The General Hospitalof PLA, 100835, Beijing, China
8The Cancer Hospital of Fujian Province, 350014, Fuzhou, China
9The First Affiliated Hospital of Xi’an Communication University, 710061, Xi’an, China
10Beijing Chest Cancer Hospital, 101149, Beijing, China
11Department of Health Beijing Hospital, 100730, Beijing, China
12Xijing Hospital of the Fourth Military Medical University, 710033, Xi’an, China
13Everlife Pharmaceutical Company, 231202, Hefei, China
14Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan

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Costello JF, Fruhwald MC, Smiraglia DJ, et al. Aberrant CpG island methylation has non-random and tumor-type-specific patterns. Nat Genet. 2000;24:132–138.

Zochbauer-Muller S, Fong KM, Virmani AK, et al. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res. 2001;61:249–255.

Esteller M, Corn PG, Baylin SB, et al. A gene hypermethylation profile of human cancer. Cancer Res. 2001;61:3225–3229.

Paz MF, Fraga MF, Avila S, et al. A systemic profile of DNA methylation in human cancer cell lines. Cancer Res. 2003; 63:1114–1121.

Fraga MF, Herranz M, Espada J, et al. A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res. 2004;64: 5527–5534.

Parrella P, Poeta ML, Gallo AP, et al. Nonrandom distribution of aberrant methylation of cancer-related genes in sporadic breast tumors. Clin Cancer Res. 2004; 10:5349–5354.

Liau MC, Lee SS, Burzynski SR. Hypomethylation of nucleic acids: a key to the induction of terminal differentiation. Intl J Exp Clin Chemother. 1989;2:187–199.

Lotem J, Sachs L. Epigenetics wins over genetics: induction of differentiation in tumor cells. Seminars Cancer Biol. 2002; 12:339–346.

Kalebic T. Epigenetic changes: potential therapeutic targets. Ann NY Acad Sci.2003;983:278–285.

Belinsky SA, Klinge DM, Stidley CA, et al. Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. Cancer Res. 2003;63:7089–7093.

Zhu WG, Otterson GA. The interaction of histone deacetylase inhibitions and DNA methyltransferase inhibitons in the treatment of human cancer cells. Curr Med Chem Anti-cancer Agents. 2003;3:187–199.

Baiocchi M, Rico CR, Pietro RP, et al. 5-Azacytidine reactivates the erythroid differentiation potential of the myeloidrestricted murine cell line 32D Ro. Exp Cell Res. 2003; 285: 258–267.

Gilbert J, Core SD, Herman JG, et al. The clinical application of targeting cancer through histone acetylation and hypomethylation. Clin Cancer Res. 2004;10:4589–4596.

Chen RZ, Pettersson U, Beard L, et al. DNA Hypomethylation leads to elevated mutation rates. Nature. 1998;395:89–93.

Eden A, Gendet F, Waghmare A, et al. Chromosomal instability and tumors promoted by DNA hypomethylation. Science. 2003;300:455.

Lin CH, Hsieh SY, Sheen IS, et al. Genome-wide hypomethylation in hepatocellular carcinogenesis. Cancer Res. 2001;61:4238–4243.

Gandet F, Hodgson JG, Eden A, et al. Induction of tumors in mice by genomic hypomethylation. Science. 2003;300:489–492.

Widschwendter M, Jiang G, Words C, et al. DNA hypomethylation and ovarian cancer biology. Cancer Res. 2004 ;64:4472–4480.

Nishiagki M, Aoyagi K, Danjoh I, et al. Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. Cancer Res. 2005; 65:2115–2124.

Liau MC, Chang CF, Sannders GF, et al. S-adenosylhomocysteine hydrolases as primary target enzymes in androgen regulation of methylation complexes. Arch Biochem Biophys. 1981;208:261–272.

Liau MC, Chang CF, Becker FF. Alteration of S-adenosylmethionine synthetases during chemical hepato-carcinogenesis and in resulting carcinomas. Cancer Res. 1979; 39: 2113–2119.

Liau MC, Chang CF, Giovanella BC. Demonstratron of an altered S-adenosylmethionine synthetase in human malignant tumors xenografted into athymic nude mice. J Natl Cancer Inst. 1980; 64:1071–1075.

Liau MC, Burzynski SR. Altered methylation complex isozymes as selective targets for cancer chemotherapy. Drugs Exp Clin Res. 1986;12(Suppl.l):77–86.

Liau MC. Abnormal methylation enzymes: a selective molecular target for differentiation therapy of cancer. Chin Pharm J. 2004; 56: 57–67.

Salem C, Liang G, Tsai YC, et al. Progressive increase in de novo methylation of CpG islands in bladder cancer. Cancer Res. 2000; 60:2473–2476.

Eads CA, Lord RV, Wickramasingle U, et al. Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res. 2001; 61:3410–3418.

Mehrotra J, Vali M, McVeigh M, et al. Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung. Clin Cancer Res. 2004;10:3104–3109.

Kishi K, Doki Y, Yano M, et al. Reduced hMLHl expression after chemotherapy is an indicator for poor prognosis in esophageal cancers. Clin Cancer Res. 2003;9:4368–4375.

Gifford G, Paul J, Vasey PA, et al. The acquisition of h MLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients. Clin Cancer Res. 2004; 10:4420–4426.

Nyce J. Drug-induced DNA hypermethylation and drug resistance in human tumors. Cancer Res. 1989;49:5829–5836.

Liau MC, Luong Y, Liau CP, et al. Prevention of drug induced DNA hypermethylation by antineoplaston components. Intl J Exp Clin Chemother. 1992;5:19–27.

Liau MC, Lee SS, Burzynski SR. Modulation of cancer methylation complex isozymes as a decisive factor in the induction of terminal differentiation mediated by Antineoplaston A5. Intl J Tiss React 1990;12(Suppl.l):27–36.

Liau MC, Huang LJ, Lee JH, et al. Development of differentiation helper inducers for the differentiation therapy of cancer. Chin Pharm J. 1998;50:289–303.

Liau MC, Liau CP. Methyltransferase inhibitors as excellent differentiation helper inducers for differentiation therapy of cancer. Bull Chin Cancer. 2002;11:166–168.

Liau MC, Szopa M, Burzynski B, et al. Chemo-surveillance: a novel concept of natural defense mechanism against cancer. Drugs Exp Clin Res. 1987;13:(Suppl.l): 77–82.

Liu YK, Li Y, Ma X, et al. Regulation of liver cancer related genes and alpha fetal protein expression by CDA -2. Bull Chin Cancer. 2002;11:169–172.

Sun JJ, Zhou XD, Liu YK, et al. Prevention of metastasis and recurrence in xenografted nude mice by differentiation inducer CDA-2. Chin Hepatobill J. 1999;5:14–16.

Xu JY, Zhou Q, Lu P, et al. Induction of apoptosis and reversal of drug resistance in human tumor cell line KBv200 by cell differentiation agent-2 (CDA-2). Chin J Intern Med. 2000;39:37–39.

Liao SK. Abrogation of telomerese activity by CDA-2. In: Liau MC. Smart Anticancer Drug CDA-2. Taipei, Taiwan: Shymou Publishing Co. 1999;188–190.

Meng ZQ, Huang, WX, Wang ZJ. Phase II clinical trial of CDA-2 on breast cancer. Bull Chin Cancer. 2002;11:113–114.

Gao YT, Shi SQ, Gu FL, et al. The effect of CDA -2 on advanced liver cancer in 15 cases. Bull Chin Cancer. 2002; 11:110–112.

Feng FY, Li Q, Wang ZJ. Effect of uroacitides in improving quality of life of advanced cancer patients. Chin J Clin Rehab. 2004;8:384–385.

Chen ZS, Ni M, Cheng HH, et al. Therapeutic efficacy of CDA-2 on advanced cancer patients: a comparison with cytotoxic chemotherapy. Chin J Clin Oncol Rehab. 1999;6:84–87.

Lai TY, Wu YW, Lin WC. Effect of an urinary preparation on acute liver injury induced by carbon tetrachloride. Chin Pharm J. 1998; 50:175–187.

Yen A. Control of HL -60 myeloid differentiation: evidence of uncoupled growth and differentiation, S-phase specificity, and two step regulation. Exp Cell Res. 1995;156:198–203.

Castro-Munezledo F, Beltran-Langarice K, Kuri-Harcnch W. Commitemt of 3T3 -F442A cells to adipocyte differentiation takes place during the first 24–34h after adipogenic stimulation: TNF inhibits commitemt. Exp Cell Res. 2003;284:161–170.