Pharmacology and therapeutic applications of agents used in heavy metal poisoning

A. Catsch1, A.-E. Harmuth-Hoene1
1Institut für Strahlenbiologie, Kernforschungszentrum, Karlsruhe, Federal Republic of Germany

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Aaseth, 1973, The effect of mercaptodextran on distribution and toxicity of mercury in mice, Acta Pharmac. Tox., 32, 430, 10.1111/j.1600-0773.1973.tb01489.x Adam, 1951, The effects of dithiols on the distribution of mercury in rabbits, Br. J. Pharmac., 6, 483 Adam, 1954, Observations on dithiols and the distribution of lead in rabbits, J. Pharm. Pharmac., 6, 403, 10.1111/j.2042-7158.1954.tb10962.x Adams, 1964, Nephrotic syndrome associated with penicillamine therapy of Wilson's disease, A. J. Med., 36, 330, 10.1016/0002-9343(64)90096-8 Ahrens, 1968, Toxicity of calcium ethulenediaminetetraacetate in dogs, 27, 1401 Ahrens, 1971, A comparative study of the toxic effects of calcium and chromium chelates of ethylenediaminetetraacetate in the dog, Toxic appl. Pharmac., 18, 10, 10.1016/0041-008X(71)90310-3 Aisen, 1967, Biocarbonate and the binding of iron to transferrin, J. biol. Chem., 242, 2484, 10.1016/S0021-9258(18)95988-0 Albahary, 1965, La desferrioxamine (DF) et le sel calcique trisodique de l'acide diéthylène triamine penta-acétique (Ca DTPA Na3) dans les sidéroses, Presse méd., 73, 73 Albahary, 1966, Saturnisme et pénicillamine, Presse méd., 74, 2193 Albahary, 1958, Inefficacité du versénate de calcium disodique (EDTA calcique) dans un cas d'intoxication volontaire par le thallium, Acta Pharmac. Tox., 38, 245 Albahary, 1961, Le dépistage de l'impréquation saturnine par un test de mobilisation du plomb, Presse méd., 69, 2121 Albahary, 1964, Traitements de soustraction du fer dansles sidéroses, Thérapue, 19, 201 Altenstetter, 1966, Dekorporation von Radionukliden (Einfluβ der isotopischen Verdünnung auf die Effektivität von DTPA), Strahlentherapie, 131, 361 Althoff, 1966, Wirkung des Desferrioxamin B auf Gewebschnitte einer Nierenhaemosiderose, Arzneim.-Forsch., 16, 768 Altman, 1962, Effects of edathamil disodium on the kidney, J. invest. Dermat., 38, 215, 10.1038/jid.1962.38 Anghileri, 1969, Interaction of ethylenediaminetetraacetic acid with plasma proteins. I. The binding of 14C-EDTA to plasma proteins, Int. J. clin. Pharmac., 2, 150 Aposhian, 1958, Protection by D-penicillamine against the lethal effects of mercuric chloride, Science, 128, 93, 10.1126/science.128.3315.93 Aposhian, 1959, N-acethyl-DL-penicillamine, a new oral protective agent against the lethal effects of mercuric chloride, J. Pharmac. exp. Ther., 126, 131 Aposhian, 1959, Metabolism in vitro of the sulphhydryl amino acids, L-and D-penicillamine, Biochem. Pharmac., 3, 38, 10.1016/0006-2952(59)90006-1 Apte, 1967, Deferoxamine and sweat iron, 125, 117 Arkhipova, 1967, Sostoyaniye nekotorykh fermentnykh sistem pri vvedeniye kompleksonov, Farmak. Toksik., 30, 230 Arkhipova, 1963, Vliyaniye dvunatriyevoy soli etilendiaminobisizopropilfosfinovoy kisloty na vyvedeniye svintsa i techeniye svintsovoy intoksikatsii v eksperimente, Gig. Truda Profess. Zabol., 7, 33 Arkhipova, 1964, Vliyaniye aminoalkilfosfinovikh kislot na eksperimentalnoye otravleniye berilliyem, Dokl. Akad. Nauk SSSR, 158, 1235 Aronson, 1971, The mechanism of renal transport and excretion of ethylenediaminetetraacetate with interspecies comparisons, Toxic. appl. Pharmac., 18, 1, 10.1016/0041-008X(71)90309-7 Aronson, 1964, Effect of two chelating agents on the distribution and excretion of lead, J. Pharmac. exp. Ther., 146, 241 Aronson, 1972, Effect of calcium and chromium chelates of ethylenediaminetetraacetate in intestinal permeability and collagen metabolism in the rat, Toxic. appl. Pharmac., 21, 440, 10.1016/0041-008X(72)90002-6 Aronson, 1968, Studies with calcium ethylenediaminetetraacetate in calves; toxicity and use in bovine lead poisoning, Toxic. appl. Pharmac., 12, 337, 10.1016/0041-008X(68)90143-9 Asatoor, 1964, Pyridoxine deficiency in the rat produced by D-penicillamine, Nature, 203, 1382, 10.1038/2031382b0 Auth, 1973, Metabolismus und Toxizität therapeutischer Chelatbildner. XIII. Mitteilung: Einfluss von Ca-DTPA auf die Zn-Konzentration der Organe, Strahlentherapie, 146, 490 Bagley, 1968, Distribution of intravenously administered ferrioxamine-59 and ferric N,N′-ethylene-bis(α imino-2-hydroxy-5-chlorophenylacetate) in rats, 127, 798 Baier, 1973, Panmyelophthise als Forge einer Behandlung der primär-chronischen Polyarthrits mit Gold und D-Pencillamin, Schweiz. Med. Wschr., 103, 1849 Bair, 1969, Radionuclide contamination and removal, Prog. nucl. Energy, Ser. 12, 2, 157 Ballou, 1962, Preliminary evaluation of several chelating agents for plutonium removal, Hlth. Phys., 8, 731, 10.1097/00004032-196212000-00027 Ballou, 1962, Removal of deposited plutonium by triethylenetetramine hexaacetic acid, Nature, 193, 1303, 10.1038/1931303a0 Ballou, 1972, Biliary plutonium excretion in the rat, Hlth. Phys., 22, 369, 10.1097/00004032-197204000-00008 Ballou, 1966, Oral therapy for deposited plutonium, Hlth. Phys., 12, 895, 10.1097/00004032-196607000-00003 Bannerman, 1965, Studies on desferrioxamine in relation to the absorption of iron, Br. J. Haemat., 11, 15, 10.1111/j.1365-2141.1965.tb00079.x Bannerman, 1962, Effect of desferrioxamine and D.T.P.A. in iron overload, Br. med. J., II, 1573, 10.1136/bmj.2.5319.1573 Barbořik, 1967, Hladina manganu v krvi dennú vylučování močí i elektrosvářečů. Vliv. CaNa2EDTA na vylučování manganu močí, Prac. lékař., 19, 155 Barnes, 1951, The effect of 2,3-dimercapto-propanol (BAL) on experimental nickel carbonyl poisoning, Br. J. Industr. Med., 8, 117 Barron, 1947, The inhibition of succinoxidase by heavy metals and its reactivation with dithiols, Biochem. J., 41, 346, 10.1042/bj0410346 Barron, 1947, Reactivation by dithiols of enzymes inhibited by lewisite, Biochem. J., 41, 69, 10.1042/bj0410069 Barron, 1947, The effect of 2:3-dimercaptopropanol on the activity of enzymes and on the metabolism of tissues, Biochem. J., 41, 78, 10.1042/bj0410078 Batchelor, 1964, Potassium diuresis induced by edathamil disodium, J. Am. med. Ass., 187, 305, 10.1001/jama.1964.03060170059020 Bates, 1967, The kinetics and mechanism of iron(III) exchange between chelates and transferrin. II. The presentation and removal with ethylenediaminetetraacetate, J. biol. Chem., 242, 2816, 10.1016/S0021-9258(18)99579-7 Batson, 1948, Acute mercury poisoning: treatment with BAL and in anuric states with continuous peritoneal lavage, Ann. intern. Med., 29, 278, 10.7326/0003-4819-29-2-278 Bauer, 1952, Acute and subacute toxicity of ethylene diamine tetraacetic acid (EDTA) salts, 11, 321 Baxter, 1973, Decorporation of monomeric plutonium by glucan and/or DTPA, Rad. Res., 55, 144, 10.2307/3573819 Bearn, 1954, Abnormalities of copper metabolism in Wilson's disease and their relationship to the aminoaciduria, J. clin. Invest., 33, 400, 10.1172/JCI102912 Beccari, 1955, Chemisch-physikalische, pharmakologische und klinische Untersuchungen über β-Mercaptoaethylamin besonders im Hinblick auf die Bleivergiftung, Arzneim.-Forsch., 5, 421 Belknap, 1952, EDTA in the treatment of lead poisoning, Industr. Med. Surg., 21, 305 Belknap, 1961, Modern trends in the treatment of lead poisoning, J. occ. Med., 3, 380 Belknap, 1954, Treatment of inorganic lead poisoning with edathamil calcium-disodium, Archs industr. occup. Med., 10, 530 Bell, 1956, Effect of oral edathamil calcium-disodium on urinary and fecal lead excretion, Archs industr. Hlth, 13, 366 Belyayev, 1962, Vliyaniye ionoobmennykh smol i kompleksonov na raspredeleniye plutoniya, vvedennovo v zheludochno-kishechnyiy trakt, 151 Belyayev, 1962, Vliyaniye nekotorykh kompleksonov na udaleniye plutoniya u krys, 156 Belyayev, 1964, Sravnitelnaya effektivnost nekotorykh kompleksov pri udalenii plutoniya-239 iz organizma zhivotnykh, Radiobiol., 4, 760 Bersin, 1957, Zur pharmakologischen Wirkung einiger anorganisch-organischer Komplexverbindungen, Archs Biochem. Biophys., 69, 507, 10.1016/0003-9861(57)90515-5 Bessman, 1952, Treatment of lead encephalopathy with calcium disodium versenate, Med. Ann. Dist. Columbia, 21, 312 Bessman, 1954, The treatment of lead encephalopathy—a method for the removal of lead during the acute stage, Pediatrics, 14, 201, 10.1542/peds.14.3.201 Bickel, 1957, A clinical and biochemical study of hepatolenticular degeneration (Wilson's disease), Q. Jl Med., 104, 527 Bizzi, 1955, Protezione verso la tossicità acuta da rame mediante l'impiego di sostance chelanti, Boll. Soc. Ital. Biol. Sper., 31, 1 Blattner, 1964, Acrodynia, J. Pediatr., 64, 607, 10.1016/S0022-3476(64)80357-7 Bluhm, 1962, d-penicillamine therapy of thrombocytopenia secondary to chrysotherapy: A case report, Arthritis Rheumatism, 5, 638 Bohne, 1972, Metabolismus und Toxizität therapeutischer Chelatbildner. XII. Mitteilung: Wirkung auf die DNS-Synthese in Kryptenzellen des Rattendarms, Strahlentherapie, 143, 106 Bohne, 1969, Die Wirkung von Desferrioxamin B und 2-(β-Aminoäthoxy)cyclohexylamintetraacetat bei der experimentellen Eisenspeicherkrankheit der Ratte und bei der primären Hämochromatose des Menschen, Arzneim.-Forsch., 19, 944 Bohne, 1967, Vergleichende Untersuchungen über die Wirksamkeit von Chelatbildnern bei der experimentellen Eisenspeicherkrankheit der Ratte, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak., 257, 409, 10.1007/BF01047657 Bohne, 1967, Metabolismus und Toxizität therapeutischer Chelatbildner. 2. Mitteilung: Einfluβ von DTPA auf die enterale Resorption von Zink, Strahlentherapie, 134, 293 Bohne, 1968, Metabolismus und Toxizität therapeutischer Chelatbildner. 5. Mitteilung: Der physiologische Verdünnungsraum des ÄDTA und DTPA, Strahlentherapie, 136, 609 Böhme, 1967, Vergleichende Untersuchungen über die Dekorporationseffektivität von d-Penicillamin, Penicillosäure und Penillosäure, Arzneim.-Forsch., 17, 19 Bömer, 1971, Metabolismus und Toxizität therapeutischer Chelatbildner. 11. Mitteilung: Einfluβ von DTPA auf die praenatale Entwicklung der Ratte, Strahlentherapie, 142, 347 Bonati, 1958, Azione di derivati della ditioetiletilendiamina sulla tossicità del mercurio, Boll. soc. Ital. Biol. Sper., 34, 1660 Bonati, 1959, Rapoorti tra costituzione chimica e tossicità di derivati cisteaminici e loro complessi metallici, Arch. Ital. Sci. Farm., 9, 125 Boulding, 1957, The treatment of metal poisoning with penicillamine, Lancet, ii, 985, 10.1016/S0140-6736(57)92006-8 Boyd, 1957, The treatment of tetraethyl lead poisoning, Lancet, i, 181, 10.1016/S0140-6736(57)92487-X Boyle, 1953, Effect of ethylenediamine tetraacetic acid on cholesterol metabolism in rabbits, Am. J. clin. Path., 23, 801, 10.1093/ajcp/23.8.801 Bozorgzadéh, 1972, Evaluation of the effectiveness of colloidal and insoluble ferrihexacyanoferrates(II) in removing internally deposited radiocaesium, Archs Int. Pharmacodyn. Thèr., 197, 175 Bradley, 1954, Oral calcium EDTA in lead intoxication of children, J. Pediatrics, 45, 297, 10.1016/S0022-3476(54)80193-4 Braun, 1959, The protective action of disodium catechol disulfonate in experimental vanadium poisoning, Toxic. appl. Pharm., 1, 38, 10.1016/0041-008X(59)90146-2 Braun, 1946, The efficacy of 2,3-dimercaptopropanol (BAL) in the therapy of poisoning by compounds of antimony, bismuth, chromium, mercury and nickel, J. Pharmac. exp. Ther., 87, 119 Brendel, 1953, Biological effects of salts of ethylenediamine tetra-acetic acid, J. Am. Pharm. Ass. Sci. Ed., 42, 123, 10.1002/jps.3030420302 Brenot, 1967, Toxicité et efficacité comparées de quatre ferrocyanures dans la décontamination du césium radioactif 134, Path. Biol., 15, 55 Brick, 1964, Evaluation of trisodium calcium diethylene-triamine penta-acetate in hemochromatosis and transfusion hemosiderosis, 568 Brodanová, 1967, Den Einfluβ von Desferrioxamin B auf das Blutzuckerverhalten bei intravenöser Glucosebelastung beim Gesunden, Klin. Wschr., 45, 161, 10.1007/BF01725074 Brown, 1967, Studies on the site of action of deferoxamine, J. Lab. clin. Med., 69, 382 Brückner, 1967, Tierexperimentelle pathologische Linsenveränderungen nach langdauernder Verabreichung hoher Dosen von Desferal, Helv. Physiol. Pharm. Acta, 25, 62 Brugsch, 1959, Fatal nephropathy during edathamil therapy in lead poisoning, Archs Industr. Hlth., 20, 285 Brugsch, 1965, Recent advances in chelation therapy, J. occ. Med., 7, 394, 10.1097/00043764-196508000-00007 Brugsch, 1965, Chelation by calcium trisodium pentetate in workers exposed to lead, New Engl. J. Med., 272, 993, 10.1056/NEJM196505132721904 Brunk, 1967, Effect of DTPA on histochemically demonstrable non-specific alkaline phosphatase, Acta Histochem., 27, 55 Brunner, 1963, Wirkungen von Desferrioxamin-Methansulfonat auf Kreislauf und Nierenfunktion, Helv. Physiol. Pharm. Acta, 21, C3 Brykalski, 1964, Dalsze badania and wplywem doustnie le podanegs EDTA na wchlanianie i wydanie olowiu, Medycyna pracy, 15, 133 Brykalski, 1963, Wplyw doustnie podanego EDTA na wchlanianie i wydalanie z ustroju olowiu wprowadzonego sama droga, Medycyna Pracy, 6, 313 Bukhtoyareva, 1968, Opukholi u kyrs, poluchavshikh pentatsin posle vedeniya plutoniya-239, Vopr. Onkol., 14, 71 Buzzo, 1953, Estudio experimental de la acción antidótica del B.A.L. en la intoxicación por talio, La Semana Médica, 277 Byers, 1959, Lead poisoning, Pediatrics, 23, 585, 10.1542/peds.23.3.585 Cameron, 1947, The possibility of toxic effects from 2:3-dimercaptopropanol in conditions of impaired renal or hepatic function, Br. J. Pharmac., 2, 59 Campana, 1951, Richerche preliminari sul diabete pancreatico sperimentale da reagenti organici dello zinco, Boll. soc. Ital. Biol. Sper., 27, 1489 Candura, 1960, L'eliminazione urinaria e fecale dello zinco durante trattamento con etilendiaminotetracetato calcio-disodico (EDTA Ca Na2), Lav. Umano, 12, 402 Carleton, 1946, The treatment of complications of arseno-therapy with BAL (British anti-lewisite), J. clin. Invest., 25, 497, 10.1172/JCI101733 Carpy, 1968, Inhibition de l'anhydrase carbonique érythrocytaire bovine par différents agents chélateurs à pH 7.4, Biochim. biophys. Acta, 151, 245, 10.1016/0005-2744(68)90179-4 Carr, 1968, Reduction in the absorption and retention of dietary strontium in man by alginate, Int. J. Radiat. Biol., 14, 225, 10.1080/09553006814551031 Cartwright, 1954, Studies on copper metabolism. XIII. Hepatolenticular degeneration, J. clin. Invest., 33, 1487, 10.1172/JCI103027 Cash, 1959, Chelating agents in the therapy of beryllium poisoning, New Engl. J. Med., 260, 683, 10.1056/NEJM195904022601402 Castellino, 1965, Effects of calcium sodium ethylenediaminetetra-acetate on the kinetics of distribution and excretion of lead in the rat, Br. J. indust. Med., 22, 172 Catalanotto, 1972, Effects of thiols on sodium chloride preference and copper and zinc metabolism in the rat, Am. J. Physiol., 222, 1594, 10.1152/ajplegacy.1972.222.6.1594 Catsch, 1959, Die Wirkung einiger Chelatbildner auf die akute Toxizität von Uranylnitrat, Klin. Wschr., 37, 657, 10.1007/BF01478404 Catsch, 1961, Die Dekorporation von Radionukliden (Untersuchungen an Radiocer und Diäthylentriaminpentaessigsäure), Strahlentherapie, 114, 565 Catsch, 1961, Dekorporation von Radionukliden durch veresterte Polyaminopolycarbonsäuren, Int. J. appl. Radiat. Isotop., 11, 131, 10.1016/0020-708X(61)90140-5 Catsch, 1961, Untersuchungen über die Dekorporation von Radiostrontium durch Chelatbildner, Int. J. Radiat. Biol., 4, 75, 10.1080/09553006114550961 Catsch, 1962, Untersuchungen über die Dekorporation von Radiostrontium, Atomkernenergie, 7, 65 Catsch, 1962, Der Ein'uβ von Chelatbildnern auf das Verhalten von Blei im Organismus, Arzneim.-Forsch., 12, 924 Catsch, 1962, Principles and trends in therapeutic removal of internally deposited radionuclides, Hlth. Phys., 8, 725, 10.1097/00004032-196212000-00026 Catsch, 1964, Zur Toxikologie der Diäthylentriaminpentaessigsäure, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak., 246, 316, 10.1007/BF00247394 Catsch, 1967, Removal of radiostrontium from the mammalian body, 265 Catsch, 1967, Experimenteller Beitrag zur Frage der Bleidekorporation durch Chelatbildner, Arzneim.-Forsch., 17, 493 Catsch, 1968 Catsch, 1968, Probleme der Chelat-Therapie, Naturwissenschaften, 55, 473, 10.1007/BF00599705 Catsch, 1971, Chelating agents, 411 Catsch, 1961, Die Beeinflussung der Resportion von Radiocer aus einem intramuskulären Depot durch Diäthylentriaminpentaessigsäure, Experientia, 17, 22, 10.1007/BF02157930 Catsch, 1957, Untersuchungen über therapeutische Möglichkeiten bei Vergiftung mit radioaktiven Spaltprodukten. 1. Mitteilung: Der Einfluβ von Chelatbildnern auf das Verhalten von Radiocer im Säugetierorganismus, Strahlentherapie, 104, 494 Catsch, 1958, Untersuchungen über therapeutische Möglichkeiten bei Vergiftung mit radioaktiven Spaltprodukten. 3. Mitteilung: Die Beein'ussung der Ausscheidung von Radiocer durch spät einsetzende Verabreichung von Diäthylentriamin-pentaessigsäure, Strahlentherapie, 107, 298 Catsch, 1965, Removal of 60Co and 65Zn from the mammalian body, Experientia, 21, 724, 10.1007/BF02138498 Catsch, 1966, Das Verhalten von Radiozink-Chelaten im Säugetierorganismus, Strahlentherapie, 130, 557 Catsch, 1958, Untersuchungen über therapeutische Möglichkeiten bei Vergiftungen mit radioaktiven Spaltprodukten. 4. Mitteilung: Der Einfluβ von Chelatbildnern auf das biologische Verhalten von Radioyttrium, Strahlentherapie, 107, 437 Catsch, 1959, Untersuchungen über therapeutische Möglichkeiten bei Vergiftungen mit radioaktiven Spaltprodukten. 5. Mitteilung: Der Einfluβ von Chelatbildnern auf das Biologische Verhalten von Radiostrontium, Strahlentherapie, 108, 63 Catsch, 1961, Removal of internally deposited radionuclides by triethylenetetraamine-hexaacetic acid, Nature, 191, 715, 10.1038/191715a0 Catsch, 1961, Vergleichende Untersuchungen über die Dekorporationseffektivität einiger neuerer Chelatbildner, Experientia, 17, 205, 10.1007/BF02160614 Catsch, 1963, Rare earths and ruthenium: metabolism and removal from the mammalian body, 191 Catsch, 1961, Der Einfluβ einiger Polyaminopolycarbonsäuren auf die Verteilung von Thorium-234 im Organismus der Ratte, Strahlentherapie, 116, 3 Catsch, 1965, Vergleichende Untersuchungen über die Toxizität der Ca- und Zn(II)-Chelate der Diäthylentriaminpentaessigsäure, Experientia, 21, 210, 10.1007/BF02141891 Catsch, 1951, Opyty po vliyaniyu etilendiamintetraatsetata na povedeniye nekotorykh izluchateley, Fond. Ural. Filial., Akad. Nauk SSSR, Sverdlovsk. Catsch, 1964, Evaluation of the efficacy of different metal chelates of DTPA in removing internally-deposited radionuclides, Int. J. Radiat. Biol., 8, 35, 10.1080/09553006414550031 Chalmers, 1963, Incidence of lead poisoning amongst badge enamellers, J. clin. Path., 16, 389 Chamberlain, 1958, Thallium poisoning, Pediatrics, 22, 1170, 10.1542/peds.22.6.1170 Chenoweth, 1946, The cardio-vascular actions of 2,3-dimercaptopropanol (BAL), J. Pharmac. exp. Ther., 87 Chenoweth, 1956, Chelation as a mechanism of pharmacological action, Pharmac. Rev., 8, 57 Chenoweth, 1968, Clinical uses of metal-binding drugs, Clin. Pharmac. Ther., 9, 365, 10.1002/cpt196893365 Chenoweth, 1946, Pharmacology of several dithiols related to 2,3-dimercaptopropanol (BAL), J. Pharmac. exp. Ther., 6–22 Chiadot, 1962, Toxicité aigué des chélatants thérapeutiques utilisables dans l'industrie nucléaire, Revue Hyg. Méd. Soc., 10, 391 Chiadot, 1964, Toxicité élimination et répartition tissulaire du D.T.P.A.-59Fe(III) chez le rat, Path. Biol., 12, 583 Chiodi, 1947, Nephrotoxic and renotropic effects of lead on white rats and its prevention by B.A.L., Nature, 160, 680, 10.1038/160680b0 Chisolm, 1963, The use of edathamil calcium disodium (EDTA) and 2,3-dimercaptopropanol (BAL) in combination for the treatment of acute lead encephalopathy, J. Pediat., 63, 843, 10.1016/S0022-3476(63)80282-6 Chisolm, 1964, Disturbances in the biosynthesis of heme in lead intoxication, J. Pediat., 64, 174, 10.1016/S0022-3476(64)80261-4 Chisolm, 1965, Chronic lead intoxication in children, Devel. Med. Child. Neurol., 7, 529, 10.1111/j.1469-8749.1965.tb10961.x Chisolm, 1967, Treatment of lead poisoning, Modern Treatment, 4, 710 Chisolm, 1968, The use of chelating agents in the treatment of acute and chronic lead intoxication in childhood, J. Pediat., 73, 1, 10.1016/S0022-3476(68)80036-8 Chisolm, 1970, Treatment of acute lead intoxication. Choice of chelating agents and supportive therapeutic measures, Clin. Tox., 3, 527, 10.3109/15563657008990125 Chisolm, 1957, The treatment of acute lead encephalopathy in children, Pediatrics, 19, 2, 10.1542/peds.19.1.2 Chromy, 1966, Some problems of the penicillamine action in hepatolenticular degeneration, Metabolism, 15, 529, 10.1016/0026-0495(66)90113-2 Cier, 1966, Sur les effets diabétogènes chez la souris de l'acide éthylène-diamine tétracétique et de certains de ses chélates, Bull. Trav. soc. Pharm. Lyon, 10, 11 Clark, 1955, Pharmacological studies on lead E.D.T.A., Br. Med. J., II, 831, 10.1136/bmj.2.4943.831-a Clarkson, 1973, Excretion and absorption of methyl mercury after polythiol resin treatment, Arch. Environ. Hlth., 26, 173, 10.1080/00039896.1973.10666251 Cleton, 1963, Synthetic chelating agents in iron metabolism, J. clin. Invest., 42, 327, 10.1172/JCI104719 Cohen, 1947, The treatment of acute gold and arsenic poisoning, J. Am. med. Ass., 133, 749, 10.1001/jama.1947.02880110015004 Cohen, 1974, Chelation of 241Am from the liver and skeleton of the adult baboon, Radiation Res., 58, 439, 10.2307/3573913 Constam, 1964, Weitere Beobachtungen über den Zinkstoffwechsel bei Diabetes mellitus, Schweiz. Med. Wschr., 94, 1104 Corcos, 1962, Neutrophilic agranulocytosis during administration of penicillamine, J. Am. med. Ass., 189, 265, 10.1001/jama.1964.03070040015003 Cotter, 1968, Treatment of cadmium poisoning with edathamil calcium disodium, J. Am. med. Ass., 166, 735, 10.1001/jama.1958.02990070021005 Courvoisier, 1954, Contribution à l'étude des sels complexes de calcium. Leur action sur la calcémie et la calciurie, Schweiz. Med. Wschr., 84, 1289 Cramér, 1965, Agranulocytos under behandling med penicillamin och antazolin, Läkarstid., 62, 449 Crawhall, 1963, Effect of penicillamine on cystinuria, Br. Med. J., I, 588, 10.1136/bmj.1.5330.588 Crismon, 1956, Vascular responses to adrenaline in the rat mesocecum after intravenous ferrous sulfate ethylenediamine tetra-acetate and beta1-globulin, Am. J. Physiol., 185, 113, 10.1152/ajplegacy.1956.185.1.113 Cumings, 1959, The treatment of hepatolenticular degeneration, 52, 62 Cumings, 1962, The metabolism of copper and Wilson's disease, 21, 29 Cuming, 1967, Effect of phenylhydrazine-induced haemolysis on the urinary excretion of iron after desferrioxamine, Lancet, i, 71 Curran, 1955, Metal chelating agents and hepatic cholesterol synthesis, 88, 101 Dagirmanjian, 1956, The effects of calcium disodium ethylenediamine tetraacetate on uranium poisoning in rats, J. Pharmac. exp. Ther., 117, 20 Dalhamn, 1953, The effect of cobalt on blood pressure respiration and mortality, and the use of dimercaprol (BAL) as antidote, Acta Pharmac. Tox., 9, 259, 10.1111/j.1600-0773.1953.tb02954.x Dalhamn, 1953, The toxicity of vanadium: Effect of vanadate on blood-pressure, respiration and mortality, and the use of dimercaprol (BAL) as antidote, Acta Pharmac. Tox., 9, 11, 10.1111/j.1600-0773.1953.tb02923.x Danielli, 1946, Development of a chemotherapy for systemic arsenical poisoning, Nature, 157, 217, 10.1038/157217a0 Danielli, 1947, BAL-INTRAV: A new non-toxic thiol for intravenous injection in arsenical poisoning, Biochem. J., 41, 325, 10.1042/bj0410325 Darwish, 1965, Metabolism of ethylenediaminetetraacetic acid (EDTA) by chickens, J. Nutr., 86, 187, 10.1093/jn/86.2.187 David, 1959, Das Knochenmark bei gewerblicher Bleivergiftung, Arch. Gewerbepath. Gewerbehyg., 17, 329, 10.1007/BF00388139 Davidson, 1964, Effect of orally administered D-penicillamine on gold deposited in the rat kidney, Arthritis Rheumatism, 7, 406, 10.1002/art.1780070407 Davis, 1967, Effect of orally administered chelating agents EDTA, DTPA and fructose on radioiron absorption in man, Aust. Ann. Med., 16, 70 Deane, 1953, The use of BAL in the treatment of acute lead encephalopathy, J. Pediat., 42, 409, 10.1016/S0022-3476(53)80453-1 Denny-Brown, 1964, Hepatolenticular degeneration (Wilson's disease), New Engl. J. Med., 270, 1149, 10.1056/NEJM196405282702203 Denny-Brown, 1951, The effect of BAL (2,3-dimercaptopropanol) on hepatolenticular degeneration (Wilson's disease), New Engl. J. Med., 245, 917, 10.1056/NEJM195112132452401 Desenne, 1969, Mobilization of iron by desferrioxamine in cases with low serum iron, Acta Haemat., 41, 129, 10.1159/000208842 Dietrich, 1969, Les cryptates, Tetrahedron, 34, 2889, 10.1016/S0040-4039(01)88300-3 Dixit, 1965, EDTA (ethylene diamine tetraacetic acid) potentiation of insulin activity as assayed by the epididymal adipose tissue technique, 118, 368 Donnelly, 1942, The stimulating influence of sodium citrate on cellular regeneration and repair in the kidney injured by uranium nitrate, J. Pharmac. exp. Ther., 75, 11 Doolan, 1967, An evaluation of the nephrotoxicity of ethylenediaminetetraacetate and diethylenetriaminepentaacetate in the rat, Tox. appl. Pharmac., 10, 481, 10.1016/0041-008X(67)90088-9 Downes, 1964, The chromium-51 complex of ethylenediaminetetraacetic acid as a soluble rumen marker, Br. J. Nutr., 18, 153, 10.1079/BJN19640015 Dreifuss, 1966, Wilson's disease (hepatolenticular degeneration) and pregnancy, J. Am. med. Ass., 195, 960, 10.1001/jama.1966.03100110128043 Duckett, 1962, Clinical and pathological findings in a case of hepatolenticular degeneration treated with penicillamine, J. Neurol. Neurosurg. Psychiat., 25, 374, 10.1136/jnnp.25.4.374 Dudley, 1955, Pathologic changes associated with the use of sodium ethylene diamine tetra-acetate in the treatment of hypercalcemia, New Engl. J. Med., 252, 331, 10.1056/NEJM195503032520901 Durlacher, 1946, The toxicological action of 2,3-dimercaptopropanol (BAL), J. Pharmac. exp. Ther., 87 Dvořák, 1969, Kolloidale Hexacyanoferrate(II) als Antidote bei der Thallium-Intoxikation, Z. ges. exp. Med., 151, 89, 10.1007/BF02045117 Dvořák, 1970, Metabolismus und Toxizität therapeutischer Chelatbildner. 8. Mitteilung: Ausscheidung von Natrium, Kalium, Magnesium und Zink, Strahlentherapie, 139, 611 Dvořák, 1970, Hexacyanoferrate(II) als Thallium-Antidote (Herstellung und Eigenschaften), Arzneim.-Forsch., 20, 1886 Dvořák, 1971, Bindung von Thallium(I) durch Hexacyanoferrate(II), Z. Naturforsch., 26b, 277, 10.1515/znb-1971-0401 Dvořák, 1970, Zur Frage der Gold Dekorporierung durch Penicillamin, Z. ges. exp. Med., 152, 352, 10.1007/BF02044918 Dvořák, 1971, Metabolisches Verhalten von kolloidalem Ferrihexacyanoferrat(II), Naunyn-Schmiedebergs Arch. exp. Path. Pharmak., 269, 48, 10.1007/BF01422015 Eagle, 1946, The systemic treatment of 227 cases of arsenic poisoning (encephalitis, dermatitis, blood dyscrasias, jaundice, fever) with 2,3-dimercaptopropanol (BAL), Am. J. Syphilis Gonorrhoe Vener. Dis., 30, 420 Eagle, 1946, The systemic treatment of experimental arsenic poisoning (mapharsen, lewisite, phenyl arsenoxide) with BAL, J. clin. Invest., 25, 451, 10.1172/JCI101728 Ebel, 1975, Metabolismus und Toxizität therapeutischer Chelatbildner. XIV. Mitteilung: Wirkung von DTPA auf die Hämatopoese, Strahlentherapie, 149, 450 Enneking, 1964, Nefrotisch syndroom na lang durig van kwik-bevattende zalf. De kwikuitscheiding met BAL en N-acetyl-de-penicillamine, Nederl. T. Geneesk., 108, 251 Ennis, 1950, Treatment of lead encephalopathy with BAL (2,3-dimercaptopropanol), Pediatrics, 5, 853, 10.1542/peds.5.5.853 Erlandson, 1963, Removal of iron from patients with secondary hemochromatosis, Blood, 22, 815 Erleksova, 1959, Osobenosti raspredeleniya i vyvedeniya poloniya u zhivotnykh pri primenenii unitiola, Medits. Radiol., 4, 54 Evered, 1960, Penicillamine and cystinuria, Br. med. J., I, 120 Eybl, 1966, Die Schutzwirkung von Chelatbildnern bei der akuten Kadmium-chloridvergiftung, Acta Biol. Med. Germ., 16, 61 Eybl, 1962, Učinek DTPA ve srovnání s EDTA v akutní experimentální otravě manganem, Cs. fysiol., 11, 232 Eybl, 1965, Über den Einfluβ der Chelatbildner auf die Ausscheidung und das Verhalten des Quecksilbers bei akuter Quecksilbervergiftung, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak., 252, 79, 10.1007/BF00246432 Eybl, 1965, Einfluβ der Chelatbildner auf die Ausscheidung des cadmiums bei Cadmiumvergiftung, Naunyn-Schiedebergs Arch. exp. Path. Pharmak., 252, 85, 10.1007/BF00246433 Eybl, 1966, Wirkung von CaÄDTA und CaDTPA bei der Kadmiumvergiftung, Acta Biol. Med. Germ., 17, 178 Eybl, 1966, Toxizität und Stoffwechsel der Kadmiumkomplexe der Aminopolykarbonsäuren, Act. Biol. Med. Germ., 16, 149 Eybl, 1969, Einfluβ der Ca-Komplexe der Aminopolycarbonsäuren auf die Ausscheidung und die Verteilung des Mangans bei der Manganvergiftung, Int. Arch. Gewerbepath. Gewerbehyg., 25, 115, 10.1007/BF00410923 Eybl, 1969, Stoffwechsel der Mangankomplexe der Aminopolycarbonsäuren, Int. Arch. Gewerbepath. Gewerbehyg., 25, 215, 10.1007/BF00678311 Eybl, 1970, Einfluβ der Ca-Komplexe der Aminopolycarbonsäuren auf die Ausscheidung und die Verteilung des Zinks, Z. ges. exp. Med., 152, 274, 10.1007/BF02044911 Eyring, 1963, Interaction of gold and penicillamine, Arthritis Rheumatism, 6, 216, 10.1002/art.1780060305 Fahey, 1961, Evaluation of trisodium calcium diethylenetriaminepentaacetate in iron storage disease, J. Lab. clin. Med., 57, 436 Fairbanks, 1963, Drugs for iron overload, Br. Med. J., I, 1414, 10.1136/bmj.1.5342.1414-b Falbe-Hansen, 1966, Treatment of ocular siderosis and haematochromatosis with desferrioxamine, Act. Ophthalm., 44, 95, 10.1111/j.1755-3768.1966.tb06437.x Fasiska, 1971, Urinary excretion of 241Am under DTPA treatment, Hlth. Phys., 21, 523, 10.1097/00004032-197110000-00003 Fateyeva, 1960, Vliyaniye Cs137 na organizm cheloveka, Medits. Radiol., 5, 14 Fellers, 1959, The nephrotic syndrome induced by penicillamine therapy, Am. J. Dis. Child., 98, 669 Ferris, 1957, Hepatolenticular degeneration, Archs Intern. Med., 99, 656, 10.1001/archinte.1957.00260040156015 Fiedler, 1969, Untersuchungen über die Toxicität des Kupferdinatriumäthyl-endiamintetraacetats, Arch. Toxikol., 25, 140, 10.1007/BF00577763 Fiedler, 1969, Zur Wirkung von Äthylendiamintetraessigsäure und Hexanethylendiamintetraessigsäure auf den Blutzucker von Meerschweinchen, Z. ges. inn. Med. Grenzgeb., 24, 311 Figueroa, 1968, Biliary iron excretion in normal and iron-loaded rats after desferrioxamine and CaDTPA, Am. J. Physiol., 215, 807, 10.1152/ajplegacy.1968.215.4.807 Figueroa, 1961, A study of iron excretion following CaDTPA administration, Clin. Res., 9, 92 Finkel, 1952, Salicylates and experimental beryllium poisoning, 79, 672 Fister, 1958, The treatment of hepatolenticular degeneration with penicillamine with report of two cases, can. med. Ass. J., 78, 99 Fitzhugh, 1946, The toxicities of compounds related to 2,3-dimercaptopropanol (BAL) with a note on their relative therapeutic efficiency, J. Pharmac. exp. Ther., 87 Fitzsimmons, 1950, Effects of BAL on tissue distribution and excretion of mercury in acute mercury poisoning, J. Pharmac., 98, 8 Fontaine, 1963, Attempt to remove thorium by use of chelating agents, J. Am. med. Ass., 184, 55, 10.1001/jama.1963.73700140008018 Foreman, 1960, The pharmacology of some useful chelating agents, 82 Foreman, 1960, Discussion remark, 156 Foreman, 1960, The application of chelating agents for hastening excretion of radioelements, 160 Foreman, 1957, Effect of ethylenediaminetetraacetic acid on deposition and excretion of certain rare earth elements, J. biol. Chem., 226, 745, 10.1016/S0021-9258(18)70856-9 Foreman, 1951, The use of chelating agents for accelerating excretion of radionuclides, AECD-3247, 1 Foreman, 1968, Nephrotoxicity of chelating agents, 419 Foreman, 1954, The metabolism of C14 labeled ethylenediaminetetraacetic acid in human beings, J. Lab. clin. Med., 43, 566 Foreman, 1953, The metabolism of C14-labeled ethylenediaminetetraacetic acid in the rat, J. biol. Chem., 203, 1045, 10.1016/S0021-9258(19)52375-4 Foreman, 1955, CaEDTA and the excretion of plutonium, Proc. Soc. exp. Biol. Med., 89, 339, 10.3181/00379727-89-21804 Foreman, 1956, nephrotoxic hazard from uncontrolled edathamil calcium-disodium therapy, J. Am. med. Ass., 160, 1042, 10.1001/jama.1956.02960470038010 Foreman, 1958, Clinical experiences with radioactive materials, Am. J. Roentgenol., 79, 1071 Forland, 1966, The renal excretion of ethylenediaminetetraacetate in the dog, J. Pharmac. exp. Ther., 153, 142 Foye, 1961, Role of metal-binding in the biological activities of drugs, J. Pharm. Sci., 50, 93, 10.1002/jps.2600500202 Freeman, 1956, Some aspects of the mechanism of toxicity of thioglycolate, J. Pharmac. exp. Ther., 118, 296 Freyer, 1963, Effect of chelating agents on the copper-protein bond in liver, Nature, 198, 189, 10.1038/198189a0 Friberg, 1956, Edathamil calcium-disodium in cadmium poisoning, Arch. indust. Health, 13, 18 Fried, 1961, Effect of chelating agent administration on the removal of monomeric and polymeric thorium, Radiation Res., 15, 227, 10.2307/3571254 Fritz, 1960, Die akute gewerbliche Dichromatvergiftung und ihre Behandlung, Klin. Wschr., 38, 856, 10.1007/BF01482144 Froitzheim, 1954, Tierexperimentelle Untersuchungen zur Behandlung der Quecksilbervergiftung mit α,α-Dimercaptobernsteinsäure, Dermat. Wschr., 129, 497 Fujioka, 1964, A Zn++ requirement for synthesis of deoxyribonucleic acid by rat liver, J. biol. Chem., 239, 1164, 10.1016/S0021-9258(18)91407-9 Furlani, 1970, Tissue radioactivity after skin application of labeled ethylenediaminetetraacetic acid in the rat, Pharmac. Res. Comm., 2, 77, 10.1016/S0031-6989(70)80012-1 Gabard, 1974, The influence of diethylenetriaminepentaacetate on the synthesis of DNA, RNA and proteins in the regenerating rat liver, Biochem. Pharm., 23, 901, 10.1016/0006-2952(74)90221-4 Galin, 1957, Studies of sodium diethyldithiocarbamate, a supposed pancreatic alpha cell toxin, Diabetes, 6, 154, 10.2337/diab.6.2.154 Gammill, 1947, Effect of 2,3-dimercaptopropanol (BAL) on acute poisoning by tervalent and quinquevalent antimonial drugs, 64, 13 Geller, 1963, Sluchay luchevoy bolezni, vyzvannoy radioaktivnym tseziem, Medits. Radiol., 8, 23 Germuth, 1948, The efficacy of BAL (2,3-dimercaptopropanol) in the treatment of experimental lead poisoning in rabbits, J. Pharmac. exp. Ther., 92, 397 Ghidoni, 1966, Effect of desferrioxamine methansulphonate (DFOM) on glucose uptake by rat epididymal adipose tissue, 121, 1039 Gibbs, 1965, Copper content of hair in normal families and those with Wilson's disease, J. med. Genet., 2, 181, 10.1136/jmg.2.3.181 Gibbs, 1966, Penicillamine and pyridoxine requirements in man, Lancet, i, 175, 10.1016/S0140-6736(66)90700-8 Gibbs, 1971, Studies with 35S-labelled DL-Penicillamine in patients with Wilson's disease, Q. Jl. Med., New Ser. XL, 158, 275 Giles, 1955, Treatment of lead poisoning with calcium disodium versenate, Lancet, i, 183, 10.1016/S0140-6736(55)91910-3 Gilman, 1946, The treatment of acute systemic mercury poisoning in experimental animals with BAL, thiosorbitol and BAL glucoside, J. clin. Invest., 25, 549, 10.1172/JCI101737 Gilman, 1946, The treatment of acute cadmium intoxication in rabbits with 2,3-dimercaptopropanol (BAL) and other mercaptans, J. Pharmac. exp. Ther., 87, 85 Ginsburg, 1948, The acute distribution of intravenously administered lead acetate in normal and BAL-treated rabbits, Br. J. Pharmac., 3, 223 Glömme, 1959, Treatment of experimental acute mercury poisoning by chelating agents BAL and EDTA, Acta med. scand., 164, 175, 10.1111/j.0954-6820.1959.tb00177.x Gokulanathan, 1964, Acute iron poisoning: Treatment with a new chelating agent, Georgetown med. Bull., 16, 238 Goldberg, 1963, Treatment of lead-poisoning with oral penicillamine, Br. Med. J., I, 1270, 10.1136/bmj.1.5340.1270 Goldstein, 1969 Goldstein, 1962, Treatment of Wilson's disease (hepatolenticular degeneration) with dl-penicillamin, Neurology, 12, 231, 10.1212/WNL.12.4.231 Graham, 1948, Toxicity of 2:3-dimercaptopropanol (BAL) in young rats, Biochem. J., 43, XXXII Graham, 1952, Glycaemic response of rabbits to 1-adrenaline and 1-noradrenaline and effect thereon of dimercaprol, J. Physiol., 118, 479, 10.1113/jphysiol.1952.sp004809 Grande, 1948, El efecto del B.A.L. (2–3 dimercaptopropanol) sobre la acción de la alozana en el perro, Revta Clin. Espan., 28, 365 Granick, 1958, Porphyrin biosynthesis in erythrocytes. II. Enzymes converting δ-aminolevulinic acid to coproporphyrinogen, J. biol. Chem., 232, 1119, 10.1016/S0021-9258(19)77426-2 Grigorescu, 1969, The effect of carrier and DTPA on the distribution of 147Pm in the rat, Atomkernenergie, 14, 147 Grunert, 1960, The effect of DL-α-lipoic acid on heavy-metal intoxication in mice and dogs, Archs Biochem. Biophys., 86, 190, 10.1016/0003-9861(60)90402-1 Grunfeld, 1963, Thallium poisoning treated with BAL, New Engl. J. Med., 269, 1138, 10.1056/NEJM196311212692110 Günther, 1971, Der Einfluβ von kolloidalem Ferrihexacyanoferrat(II) auf die Verteilung und Toxicität von Thallium, Arch. Toxikol., 28, 39, 10.1007/BF00349626 Günther, 1969, Der Einfluβ von Chelatbildnern auf die Verteilung und Ausscheidung von Radioeisen bei der Ratte, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak., 262, 405, 10.1007/BF00537838 Gustafson, 1944, Effect of sodium citrate on uranium poisoning in dogs, Archs. Intern. Med., 74, 416, 10.1001/archinte.1944.00210240006002 Haddock, 1965, Biliary excretion of chelated iron, 120, 663 Hahn, 1966, The effect of desferrioxamine B upon the enzymatic catalase and PDD-oxydase activity in plasma and serum, Acta med. scand. Suppl., 445, 276 Hald, 1952, The antabuse effect of some compounds related to antabuse and cyanamide, Acta Pharmac. Tox., 8, 329, 10.1111/j.1600-0773.1952.tb02910.x Hall, 1969, Inhibition of iron absorption by magnesium trisilicate, Med. J. Aust., 2, 95, 10.5694/j.1326-5377.1969.tb105628.x Hallauer, 1974, Immunkomplex-nephritis mit nephrotischem Syndrom unter Therapie mit D-Penizillamin, Schweiz. Med. Wschr., 104, 434 Hallberg, 1965, The effect of desferrioxamine on iron metabolism in man, Scand. J. Haemat., 2, 67, 10.1111/j.1600-0609.1965.tb01280.x Hammond, 1971, The effect of chelating agents on the tissue distribution and excretion of lead, Toxic. appl. Pharm., 18, 296, 10.1016/0041-008X(71)90121-9 Hammond, 1973, The effects of D-penicillamine on the tissue distribution and excretion of lead, Toxic. appl. Pharm., 26, 241, 10.1016/0041-008X(73)90257-3 Hammond, 1973, The relationship between inhibition of δ-aminolevulinic acid dehydratase and lead mobilization by ethylenediamine tetraacetate (EDTA), Toxic. appl. Pharm., 26, 466, 10.1016/0041-008X(73)90283-4 Hammond, 1960, The mobilization and excretion of lead in cattle: A comparative study of various chelating agents, Ann. N.Y. Acad. Sci., 88, 498, 10.1111/j.1749-6632.1960.tb20047.x Hammond, 1964, Observed effects of plutonium in wounds over a long period of time, Hlth. Phys., 10, 399, 10.1097/00004032-196406000-00003 Hammond, 1967, The mechanism of mobilization of lead by ethylenediaminetetraacetate, J. Pharmac. exp. Ther., 157, 196 Hammond, 1968, Americium and plutonium urine excretion following acute inhalation exposures to high-fired oxides, Am. Industr. Hyg. Ass. J., 29, 169, 10.1080/00028896809343293 Hansard, 1964, Effects of hydrobiotites upon strontium-89 and caesium-137 retention by ruminant animals, 115, 346 Hardy, 1954, Use of monocalcium disodium ethylene diamine tetraacetate in lead poisoning, J. Am. Med. Ass., 154, 1171, 10.1001/jama.1954.02940480023007 Harker, 1968, Evaluation of storage iron by chelates, Am. J. Med., 45, 105, 10.1016/0002-9343(68)90012-0 Harmuth-Hoene, 1967, Metabolismus und Toxizität therapeutischer Chelatbildner. 1. Mitteilung: vergleichende Untersuchungen über die Ausscheidung von ÄDTA und DTPA im Urin der Ratte, Strahlentherapie, 134, 110 Harmuth-Hoene, 1965, Excretion of 65Zn-DTPA in the rat, Int. J. Radiat. Biol., 10, 479, 10.1080/09553006614550571 Harmuth-Hoene, 1970, Iron(III)-exchange between transferrin and chelates in vitro, Chem. Biol. Interactions, 1, 271, 10.1016/0009-2797(70)90014-1 Harris, 1958, A comparison of intravenous calcium disodium versenate and oral penicillamine in promoting elimination of lead, Can. med. Ass. J., 79, 664 Harris, 1966, Effect of penicillamine on human collagen and its possible application to treatment of scleroderma, Lancet, ii, 996, 10.1016/S0140-6736(66)92926-6 Harrison, 1946, The treatment by 2,3-dimercaptopropanol (BAL) of the systemic toxic effects of skin contamination with lewisite and phenyldichlorarsine, J. Pharmac. exp. Ther., 87, 81 Harrison, 1946, Poisoning from inhalation of the vapors of lewisite and phenyldichlorarsine: Its pathology in the dog and treatment with 2,3-dimercaptopropanol (BAL), J. Pharmac. exp. Ther., 87 Hartley, 1963, Penicillamine and mixed disulphide excretion in Wilson's disease, Lancet, II, 434, 10.1016/S0140-6736(63)92174-3 Havlíček, 1967, Der Einfluβ von Ferricyanoferrat(II) auf das Verhalten von Radiocaesium bei graviden und laktierenden Ratten, Studia biophysica, 2, 239 Havlíček, 1967, Metabolismus und Toxizität therapeutischer Chelatbildner. 3. Mitteilung: Einfluβ von ÄDTA und DTPA auf die Ausscheidung von endogenem Zink, Strahlentherapie, 134, 296 Havlíček, 1968, Metabolism of radiocaesium during gestation and lactation as influenced by ferric-cyanoferrate(II), Int. J. appl. Radiat. Isotop., 19, 487, 10.1016/0020-708X(68)90104-X Havlíček, 1968, Metabolismus und Toxizität therapeutischer Chelatbildner. 4. Mitteilung: Exkretion und metabolischer Abbau von ÄDTA und DTPA, Strahlentherapie, 136, 604 Havlíček, 1968, Vliv berlínske modři na rozdělení 134Cs u psů krmených kontaminovaným masem, Veter. Med., 13, 189 Havlíček, 1967, Die Wirkung von Zyanoferraten auf die Ausscheidung von Radiozäsium bei Ratten und Ziegen, Strahlentherapie, 134, 123 Heller, 1963, Some aspects of chelation chemistry, 347 Heller, 1959, Einige physikalisch-chemische Überlegungen zur Dekorporierung radioaktiver Metalle durch Komplexbildner, Strahlentherapie, 109, 464 Henningsen, 1973, Nephrotisches Syndrom durch Penicillamin, Dtsch. Med. Wschr., 98, 1768, 10.1055/s-0028-1107125 Herring, 1963, Hepatolenticular degeneration: Observations on a case treated with D-penicillamine, J. Pediat., 63, 550, 10.1016/S0022-3476(63)80365-0 Hesp, 1965, Effect of sodium alginate in inhibiting uptake of radiostrontium by the human body, Nature, 208, 1341, 10.1038/2081341a0 Heydlauf, 1968, Tierexperimentelle Untersuchungen zur Therapie der Thalliumvergiftung, KFK-Report 875 Heydlauf, 1969, Ferric-cyanoferrate(II): An effective antidote in thallium poisoning, Eur. J. Pharmac., 6, 340, 10.1016/0014-2999(69)90194-0 Heyl, 1948, The chemistry of vitamin B6. VI. Pyridoxylamino acids, J. Am. chem. Soc., 70, 3429, 10.1021/ja01190a061 Heyndrickx, 1957, Treatment of thallium poisoning in mice. Toxicological analysis by radioactivation, Acta Pharmac. Tox., 14, 20, 10.1111/j.1600-0773.1957.tb01138.x Hildner, 1964, Congenital erythroblastic hypoplasia, Henry Ford Hosp. med. Bull., 12, 5 Hill, 1959, The action of chelating agents in Wilson's disease, Lancet, ii, 444, 10.1016/S0140-6736(59)90426-X Hirschman, 1965, The nephrotic syndrome as a complication of penicillamine therapy for hepatolenticular degeneration (Wilson's disease), Ann. Intern. Med., 62, 1297, 10.7326/0003-4819-62-6-1297 Hirschman, 1963, Mercury in house paint as a cause of acrodynia, New Engl. J. Med., 269, 889, 10.1056/NEJM196310242691703 Hodge, 1951, Antidotal action of polyphosphates in uranium poisoning, J. Pharmac. exp. Ther., 101, 17 Holland, 1953, Use of ethylene diamine acetic acid in hypercalcemic patients, 84, 359 Hollister, 1966, Antipyridoxine effect of D-penicillamine in schizophrenic men, J. clin. Nutr., 19, 307, 10.1093/ajcn/19.5.307 Holtzmann, 1963, Zur Verwendung von Desferrioxamin bei Porphyria cutanea tarda, Med. Welt, 1078 Hösli, 1960, Die Behandlung der Sklerodermie mit dem di-Natriumsalz der Äthylen-Diamin-Tetraessigsäure; ein Beitrag zur Toxikologie der Versenate; 2. Mitteilung, Arzneim.-Forsch., 10, 177 Hsia, 1966, Hepatolenticular degeneration: The comparative effectiveness of D-penicillamine, potassium sulfide, and diethyldithiocarbamate as decoppering agents, J. Pediatrics, 68, 921, 10.1016/S0022-3476(66)80211-1 Huisman, 1950, The effect of BAL on the blood sugar level, Acta Physiol. Pharmac. Neerl., 1, 184 Hursh, 1951, The effect of BAL on the excretion and tissue distribution of polonium in rats, J. Pharmac. exp. Ther., 103, 450 Hursh, 1952, Effect of BAL on survival of rats after lethal doses of polonium, 79, 210 Hwang, 1964, Evaluation of deferoxamine in iron overload, Archs Intern Med., 114, 741, 10.1001/archinte.1964.03860120053003 Hwang, 1965, Effect of desferrioxamine on iron absorption, Lancet, i, 135, 10.1016/S0140-6736(65)91093-7 Ivemark, 1957, Renal damage in rats from the lead salt of EDTA and from umbracil, Acta Radiol., 48, 366, 10.3109/00016925709170969 Jacobus, 1969, Osteolathyrogenic effect of penicillamine, Am. J. Path., 54, 21 Jaffe, 1964, The antipyridoxine effect of penicillamine in man, J. clin. Invest., 43, 1869, 10.1172/JCI105060 Jammers, 1967, Isotopischer Austausch von Zink zwischen Proteinen und Polyamino-polycarboxylsäuren, Naturwissenschaften, 54, 588, 10.1007/BF00636825 Jax, 1973, Die Therapie der Thalliumvergiftung, Med. Welt, 24, 691 Jech, 1972, Interpretation of human urinary excretion of plutonium for cases treated with DTPA, Hlth. Phys., 22, 782, 10.1097/00004032-197206000-00039 Jellum, 1973, Mercaptodextran, a metal-chelating and disulphide reducing polythiol of high molecular weight, Biochem. Pharmac., 22, 1179, 10.1016/0006-2952(73)90235-9 Johanson, 1956, Lead E.D.T.A. as a contrast medium, Br. med. J., I, 573, 10.1136/bmj.1.4966.573-c Jolly, 1972, Treatment and evaluation of a plutonium-238 nitrate contaminated wound, Hlth. Phys., 23, 333, 10.1097/00004032-197209000-00007 Kabachnik, 1972, Isledovaniye v oblasti teorii deystviya i primeneniya fosforosoderzhashchikh kompleksoobrazuyushchikh soyedineniy, Trud. 4 Konfer. Khimiya i primeneniya fosforoorganicheskikh soyedineniy, 237 Kadota, 1951, Diabetogenic action of organic reagents: Destructive lesions of islets of Langerhans caused by sodium diethyldithiocarbamate and potassium ethylxanthate, J. Lab. clin. Med., 38, 671 Kamerbeck, 1971, Prussian blue in therapy of thallotoxicosis, Acta med. scand., 189, 321, 10.1111/j.0954-6820.1971.tb04383.x Karpinski, 1953, Calcium disodium versenate in the therapy of lead encephalopathy, 42, 687 Kawin, 1952, Effect of 2,3-dimercaptopropanol (BAL) upon distribution and excretion of plutonium, Proc. Soc. exp. Biol. Med., 84, 576, 10.3181/00379727-84-20716 Kazantzis, 1962, Albuminum and the nephrotic syndrome following exposure to mercury and its compounds, Q.J. Med., New Ser., 31, 403 Keberle, 1964, The biochemistry of desferrioxamine and its relation to iron metabolism, Ann. N.Y. Acad. Sci., 119, 758, 10.1111/j.1749-6632.1965.tb54077.x Kekki, 1966, Influence of penicillamine on the turnover of J131-labeled ceruloplasmin in Wilson's disease, Metabolism, 15, 1029, 10.1016/0026-0495(66)90052-7 Kety, 1941, Treatment of lead poisoning with sodium citrate, Proc. Soc. exp. Biol. Med., 46, 476, 10.3181/00379727-46-12033P Kincaid, 1953, Nickel poisoning. I. Experimental study of the effects of acute and subacute exposure to nickel carbonyl, Arch. industr. Hlth occup. Med., 8, 48 Kirimlidis, 1966, The treatment of hemosiderosis in thalassaemia major with desferrioxamine-B, Helv. paediatr. Acta, 21, 343 Kitzmiller, 1954, Treatment of organic (tetraethyl) lead intoxication with edathamil calcium-disodium, Arch. industr. Hyg. Occup. Med., 10, 312 Klimmer, 1968, Schwermetallantidote, Arch. Tox., 24, 15, 10.1007/BF00577524 Knoblauch, 1965, Wirkung von Desferrioxamin auf Schnitte von Hämochromatoselebern, Klin. Wschr., 43, 266, 10.1007/BF01482248 Köcher, 1959, Der Einfluβ von CaNa2EDTA auf die experimentelle Metallvergiftung. IV. Mitteilung, Archs. Int. Pharmacodyn. Thér., 120, 80 Kosai, 1956, Ethylenediaminetetraacetic acid in manganese poisoning of rats, Indust. Med. Surg., 25, 1 Koshurnikova, 1969, Vliyaniye profilakticheskovo vdykhaniya pentatsina no otdalennye posledstviya ingalatsii Pu239, Medits. Radiol., 14, 29 Kostial, 1962, Utjecaj helatogenih supstancija na retenciju urana u bubrezima, Archiv Hig. Rada Toksikol., 13, 289 Koutenský, 1967, Přispěvek k metabolismu manganatých komplexů aminopolykarbonových kyselin, Prac. Lékař., 19, 52 Krivchenkova, 1960, Izucheniye deystviya dietilditiokarbaminata natriya pri proazhenii poloniyem, Medits. Radiol., 5, 53 Kroll, 1960, The effect of structural modifications on polyamineacetic acid chelating agents, Ann. N.Y. Acad. Sci., 88, 341, 10.1111/j.1749-6632.1960.tb20033.x Kroll, 1957, Excretion of yttrium and lathanum chelates of cyclohexane 1,2-trans diamine tetraacetic acid and diethylene tramine pentaacetic acid in man, Nature, 180, 919, 10.1038/180919b0 Kuchinskas, 1957, An increased vitamin B6 requirement in the rat on a diet containing L-penicillamine, Archs Biochem. Biophys., 66, 1, 10.1016/0003-9861(57)90531-3 Kuhn, 1968, Dekorporation von Radio-Mangan durch Isotopen-Austausch, Naturwissenschaften, 55, 38, 10.1007/BF00593414 Kuhn, 1969, Dekorporation von Radionukliden (Untersuchungen an Radiomangan), Strahlentherapie, 137, 101 Kuschinsky, 1954, Die Behandlung der experimentellen Quecksilbervergiftung mit 2,3 Dimercaptopropionsäure, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak., 223, 408, 10.1007/BF00247455 Kuzell, 1947, The effects of 2,3-dimercaptopropanol (BAL) on toxicity and excretion of gold, Stanford med. Bull., 5, 197 Lachnit, 1959, Die Therapie der Bleiintoxikation, Wien. Z. Inn. Med., 40, 321 Lachnit, 1961, Zur Frage der nephrotoxischen Wirkung des Calciumdinatriumäthylendiamintetraacetats, Arch. Gewerbepath. Gewerbehyg., 18, 495, 10.1007/BF00313764 Lagerquist, 1965, Effectiveness of early DTPA treatments in two types of plutonium exposures in humans, Hlth. Phys., 11, 1177, 10.1097/00004032-196511000-00005 Lagerquist, 1967, Plutonium excretion following contaminated acid burns and prompt DTPA treatments, Hlth. Phys., 13, 1, 10.1097/00004032-196701000-00001 Lange, 1964, Die Therapie der Schwermetallspeicherungen und -vergiftungen mit Komplexbildnern, Berl. Medizin., 15, 109 Lange, 1967, Die Langzeitbehandlung des Morbus Wilson mit D-penicillamin, Dtsch. Med. Wschr., 92, 1657, 10.1055/s-0028-1106021 Lange, 1959, Zur Diagnostik und Therapie von Bleischäden mit Komplexibildnern, Ärztl. Wschr., 14, 105 Lange, 1964, Zur Therapie der chronischen Manganvergiftung mit Komplexbildnern, Verh. Dtsch. Ges. Inn. Med., 355 Larson, 1968, The management of an extensive plutonium wound and the evaluation of the residual internal deposition of plutonium, Phys. Med. Biol., 13, 45, 10.1088/0031-9155/13/1/305 Lazaris, 1963, The diabetogenic action of zinc-blocking substances, Uch. Zap. Karagand. Med. Inst., 2, 3 Lê, 1964, Distribution of cobalt-60 in the rat as influenced by chelating agents, Nature, 204, 696, 10.1038/204696a0 Lê, 1965, Neue Möglichkeiten der Chelat-Therapie der Hämosiderose, Arzneim.-Forsch., 15, 387 Leckie, 1958, The diagnostic and therapeutic use of edathamil calcium disodium (EDTA, versene) in excessive inorganic lead absorption, Quart. J. Med., New Ser., 27, 65 Lehn, 1973, Design of organic complexing agents. Strategics towards properties, Structure and Bonding, 16, 1, 10.1007/BFb0004364 Lehnert, 1970, Zum Problem der medikamentösen Prophylaxe beruflicher Schwermetallintoxikationen mit D-Penicillamin, Med. Welt, 9, 346 Levine, 1970, Heavy-metal antagonists, 944 Liberman, 1967, Myositis ossificans traumatica with unusual course effect of EDTA on calcium, phosphorus and manganese excretion, Am. J. Med. Sci., 254, 35, 10.1097/00000441-196707000-00004 Lieberman, 1962, Deoxyribonucleic acid synthesis and its inhibition in mammalian cells cultured from the animal, J. biol. Chem., 237, 1634, 10.1016/S0021-9258(19)83754-7 Lindenbaum, 1956, Autoradiographic study of localization of aurintricarboxylic acid in experimental beryllium poisoning, 92, 354 Lindenbaum, 1960, Sustained action of injected chelating agents, Nature, 187, 575, 10.1038/187575a0 Lindenbaum, 1954, Studies on the mechanism of protection by aurintricarboxylic acid in beryllium poisoning. V, Archs Biochem. Biophys., 52, 143, 10.1016/0003-9861(54)90095-8 Lindenbaum, 1954, Studies on the mechanism of protection by aurintricarboxylic acid in beryllium poisoning. III, Archs. Biochem. Biophys., 52, 110, 10.1016/0003-9861(54)90093-4 Lindlar, 1953, Die Behandlung der experimentellen akuten Thalliumvergiftung mit 2,3-Dimercaptopropanol (BAL), Naunyn-Schmiedebergs Arch. exp. Path. Pharmak., 217, 288, 10.1007/BF00245471 Lisco, 1955, The modification of beryllium-induced tissue damage in mice by therapy with aurintricarboxylic acid, Br. J. exp. Path., 36, 27 Litin, 1960, Effect of D,L-penicillamine on the urinary excretion of copper and calcium in hepatolenticular degeneration (Wilson's disease), Neurology, 10, 123, 10.1212/WNL.10.2.123 Lloyd, 1974, Decorporation of 241Am in beagles by DTPA, COO-119-249, 125 Lockie, 1947, Treatment of two reactions due to gold, J. Am. med. Ass., 133, 754, 10.1001/jama.1947.02880110020006 Longcope, 1946, The treatment of acute mercury poisoning by BAL, J. clin. Invest., 25, 557, 10.1172/JCI101738 Longcope, 1949, Use of british anti-lewisite (BAL) in treatment of poisoning by arsenic, mercury, and other metals, Adv. int. Med., 3, 1 Longcope, 1950, The treatment of acute mercury bichloride poisoning with BAL (2,3-dimercaptorropanol), Med. Clin. N. Am., 34, 469, 10.1016/S0025-7125(16)35448-7 Losowsky, 1966, Effect of desferrioxamine in patients with iron-loading with a simple method for estimating urinary iron, Clin. Path., 19, 165, 10.1136/jcp.19.2.165 Lotz, 1966, D-Penicillamine therapy in cystinuria, J. Urology, 95, 257, 10.1016/S0022-5347(17)63443-8 Leutscher, 1946, The effect of BAL on the excretion of arsenic in arsenical intoxication, J. clin. Invest., 25, 534, 10.1172/JCI101735 Lund, 1956, The effect of various substances on the excretion and the toxicity of thallium in the rat, Acta Pharmac. Tox., 12, 260, 10.1111/j.1600-0773.1956.tb01386.x Lusky, 1950, Sodium catechol disulphonate protection in experimental uranium nitrate poisoning, 9, 297 Lusky, 1949, The effect of BAL on experimental lead, tungsten, vandium, uranium and copper-arsenic poisoning, J. industr. Hyg. Toxic., 31, 301 Lyle, 1968, Enhancement of cadmium nephrotoxicity by penicillamine in the rat, Postgrad. Med. J., 18–21 Lyubchanskiy, 1965, Primeneniye Na3DTPA (Pentatsina) dlya udaleniya Pu239 iz organizma krys pri ingalatsionnom porazhenii, Medits. Radiol., 10, 45 Lyubchanskiy, 1968, Profilakticheskoye primeneniye aerozoley DTPA u krys pri kronicheskoy ingalatsii Pu239, Medits. Radiol., 13, 46 MacDonald, 1964 MacNider, 1964, Liver injury in the dog following use of 2–3-dithiopropanol, 66, 444 MacNider, 1948, Inability of 2–3-dithiopropanol (BAL) to protect the liver against toxic action of uranium nitrate, 67, 160 MacNider, 1948, Concerning the inability of 2,3-dithiopropanol (BAL) to prevent or to modify the acute renal injury induced by uranium nitrate, J. Pharmac. exp. Ther., 94, 262 Madshus, 1968, Increased excretion of 137Cs in humans by prussian blue, Z. Naturforschg., 23Db, 391, 10.1515/znb-1968-0321 Madshus, 1966, Diminution of radiocaesium body-burden in dogs and human beings by prussian blue, Int. J. Radiat. Biol., 10, 519, 10.1080/09553006614550611 Maehder, 1955, Die Beryllium-Intoxikation und ihre Beeinflussung durch perkutane Salizylgabe, Med. Wschr., 9, 249 Magos, 1969, Combined effect of sodium maleate and some thiol compounds on mercury excretion and redistribution in rats, Br. J. Pharmac., 35, 121, 10.1111/j.1476-5381.1969.tb07972.x Mandelbrote, 1948, Studies on copper metabolism in demyelinating diseases of central nervous system, Brain, 71, 212, 10.1093/brain/71.2.212 Manville, 1955, Recent developments in the care of workers exposed to lead, Archs. industr. Hlth., 12, 528 Markley, 1963, Removal of polymeric from mice by combined therapy with the calcium chelate and penta-ethyl ester of DTPA, Int. J. Radiat. Biol., 7, 405, 10.1080/09553006314551351 Markley, 1964, Distribution and removal of monomeric and polymeric plutonium in rats and mice, Int. J. Radiat. Biol., 8, 271, 10.1080/09553006414550281 Markus, 1955, Treatment of chronic lead-poisoning with calcium disodium versenate, Br. med. J., II, 883, 10.1136/bmj.2.4944.883 Marras, 1955, Tentativi di protezione mediante cisteamina nell avvelenamento da tallio, Arch. Ital. Sci. Farmacol. Ser. 3, 5, 253 Martin, 1963, Étude comparée d'un nouveau chélateur du plomb le sel monocalcique et trisodique de l'acidé diéthylène triamine pentacétique (CaDTPA) et du sel monocalcique et disodique de l'acide éthylène diamine tétracétique (CaEDTA) dans le dépistage du saturnisme, Arch. Malad. Profess., 24, 297 Martin, 1964, Action du sel trisodique et monocalcique de l'acide diéthylène-triamine-penta-acétique (Ca D.T.P.A.Na3) dans le saturnisme humain, Arch. Malad. Profess., 25, 407 Mather, 1960, Thallium intoxication in dogs, J. Am. Veter. Med. Ass., 137, 544 Mazzel, 1949, Subacute poisoning by thallium treated with BAL, Br. med. J., II, 791, 10.1136/bmj.2.4631.791 McCall, 1967, Comparative metabolism of copper and zinc in patients with Wilson's disease (hepatolenticular degeneration), Am. J. med. Sci., 254, 13, 10.1097/00000441-196707000-00002 McCane, 1946, Observations on the administration of BAL-intrav to man, Nature, 157, 837, 10.1038/157837a0 McClanahan, 1968, Treatment of plutonium-contaminated wounds with diethylenetraiminepentaacetic acid in rats, 395 McDonald, 1946, Effect of BAL-intrav on excretion of copper by the sheep, Nature, 157, 837, 10.1038/157837b0 McDonald, 1966, Deferoxamine and diethylenetriaminepentaacetic acid (DTPA) in thalassemia, J. Pediat., 69, 563, 10.1016/S0022-3476(66)80041-0 Megirian, 1953, The metabolic fate of synthetic metaphosphates and their influence on uranium excretion, UR-281 Meltzer, 1961, Hypoglycaemia induced by disodium ethylenediamine tetra-acetic acid, Lancet, ii, 637, 10.1016/S0140-6736(61)90312-9 Meyer, 1957, Studies on thallium poisoning. I. The detoxifying action of some compounds containing sulphur and labile methyl groups, J. Sci. Food Agric., 8, 516, 10.1002/jsfa.2740080905 Meyer-Brunot, 1967, The metabolism of desferrixomaine B and ferrioxamine B, Biochem. Pharmac., 16, 527, 10.1016/0006-2952(67)90100-1 Millar, 1954, Influence of ethylenediamine-tetra-acetic acid on the excretion of zinc by the rat, Nature, 174, 881, 10.1038/174881a0 Misra, 1966, The passage of drugs across the rat intestine in vitro, J. Pharm. Pharmac., 18, 246, 10.1111/j.2042-7158.1966.tb07859.x Mitchell, 1953, Antagonism of toxicity of vanadium by ethylenediamine tetra acetic acid in mice, 83, 346 Mitchell, 1954, Ascorbic acid and ethylene diamine tetraacetate as antidotes in experimental vanadium poisoning, 85, 206 Mjølnerød, 1971, Congenital connective-tissue defect probably due to D-penicillamino treatment in pregnancy, Lancet, i, 673, 10.1016/S0140-6736(71)92681-X Modell, 1946, Toxicity of 2,3-dimercaptopropanol (BAL) in cats, J. Pharmac. exp. Ther., 87, 33 Modell, 1946, Pharmacologic observations on BAL by intramuscular injections in man, J. clin. Invest., 25, 480, 10.1172/JCI101731 Möhrle, 1970, Inkorporationsrisiken und deren Abschätzung, Radiologe, 10, 381 Moeschlin, 1957, Zur Klinik und Therapie der Bleivergiftung mit Bericht über eine tödliche toxische Nephrose durch Ca-EDTA (Calciumversenat), Schweiz. Med. Wschr., 87, 1091 Moeschlin, 1950, Epileptiforme Anfälle bei Thalliumvergiftung, Schweiz. Med. Wschr., 80, 519 Moeschlin, 1952, Therapie der experimentellen Thalliumvergiftung mit stabilisiertem Schwefelwassertoff oder BAL, Schweiz. Med. Wschr., 82, 57 Moeschlin, 1952, Vergleichende Untersuchungen über den therapeutischen Effekk von BAL oder Natriumcitrat bei der experimentellen Bleivergiftung, Schweiz. Med. Wschr., 82, 1164 Moeschlin, 1963, Treatment of primary and secondary hemochromatosis and acute iron poisoning with a new, potent iron-eliminating agent (desferrioxamine-B), New Engl. J. Med., 269, 57, 10.1056/NEJM196307112690201 Moncrieff, 1964, Lead poisoning in children, Archs. Dis. Child., 39, 1, 10.1136/adc.39.203.1 Müller, 1969, Cs137-Dekorporation mit kolloidal-löslichen Berliner Blau bei der Ratte, Strahlentherapie, 137, 705 Müller, 1970, Sr-85 decorporation with a cryptating agent, Naturwissenchaften, 57, 248, 10.1007/BF01010278 Müller, 1974, Long-term treatment of cesium 137 contamination with colloidal and comparison with insoluble prussian blue in rats, Strahlentherapie, 147, 319 Munari, 1956, Richerche sperimentali sull'intossicazione da cobalto e suo trattamento con CaEDTA Na3, Fol. Med., 39, 260 Nadolny, 1971, Metabolismus und Toxizität therapeutischer Chelatbildner. 10. Mitteilung: Die Ausscheidung von endogenem Mangan, Strahlentherapie, 141, 100 Nenot, 1970, Etude expérimental des contaminations par le curium-242 et leur traitement, Hlth. Phys., 18, 613, 10.1097/00004032-197006000-00002 Neuman, 1949, Attempted prevention and therapy of uranium poisoning, Vol. 1, 976 Nielsen, 1963, Influence of desferrioxamine on the renal excretion of iron, Acta med. scand., 173, 499, 10.1111/j.0954-6820.1963.tb17433.x Niemann, 1968, Zur Therapie der Bleivergiftung mit D-Penicillamin, Arbeitsmed. Sozialmed. Arbeitshyg., 3, 224 Niemeier, 1967, Der Einfluβ von Chelatbildnern auf Verteilung und Toxicität von Cadmium, Int. Arch. Gewerbepath. Gewerbehyg., 24, 160, 10.1007/BF00369020 Nigrović, 1963, Der Einfluβ von Chelatbildnern auf das Verhalten von Quecksilber im Organismus, Arzneim.-Forsch., 13, 787 Nigrović, 1963, Enhancement of the excretion of radiocaesium in ratbs by ferric cyanoferrate(II), Int. J. Radiat. Biol., 7, 307, 10.1080/09553006314551221 Nigrović, 1964, In vivo-Inaktivierung der alkalischen Phosphatase durch DTPA und ÄDTA, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak., 249, 206, 10.1007/BF00247013 Nigrović, 1965, Retention of radiocaesium by the rat as influenced by Prussian Blue and other compounds, Phys. Med. Biol., 10, 81, 10.1088/0031-9155/10/1/308 Nigrović, 1965, Tierexperimentelle Untersuchungen zur Behandlung der akuten Eisenvergiftung, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak., 251, 225, 10.1007/BF00420174 Nigrović, 1965, Dekorporation von Radionukliden (Vergleichende Untersuchungen an Desferrioxamin B und Diäthylentriaminpentaessigsäure), Strahlentherapie, 128, 283 Nigrović, 1966, Dekorporation von Radionukliden (Untersuchungen an Radiocaesium), Strahlentherapie, 130, 413 Nigrović, 1967, Untersuchungen zur Frage der enteralen Eisenresorption, 147 Nimni, 1965, Accumulation of a collagen precursor in the skin of penicillamine-treated rats, Biochim. Biophys. Acta, 111, 576, 10.1016/0304-4165(65)90078-4 Nimni, 1965, Collagen defect induced by penicillamine, Science, 150, 905, 10.1126/science.150.3698.905 Ninomiya, 1966, Stimulatory effect of chelating agents and mesoxalate on the in vivo release of insulin in the pancreas of the dog, Diabetes, 15, 44, 10.2337/diab.15.1.44 Nofre, 1962, L'activité radiomimétique de l'ion ferreux chélaté, Path. Biol., 10, 1203 Nofre, 1963, Toxicité comparée de quelques ions métalliques et de leur chélate a l'acide éthylènediaminetétracétique, Path. Biol., 11, 853 Noifralise, 1966, L'intoxication thallique et ses antidotes, Ann. biol. Clin., 24, 717 Nordöy, 1962, Wilson's disease, Acta med. scand., 172, 445, 10.1111/j.0954-6820.1962.tb07177.x Norseth, 1973, The effect of chelating agents on biliary excretion of methyl mercuric salts in the rat, Acta pharmac. tox., 32, 1, 10.1111/j.1600-0773.1973.tb01446.x Norwood, 1960, DTPA-effectiveness in removing internally deposited plutonium from humans, J. Occ. Med., 2, 371, 10.1097/00043764-196008000-00002 Norwood, 1962, Therapeutic removal of plutonium in humans, Hlth. Phys., 8, 747, 10.1097/00004032-196212000-00031 Norwood, 1962, Long-term administration of DTPA for plutonium elimination. A follow-up study in one patient, J. Occ. Med., 4, 130 Ogawa, 1960, Studies on the excretion and distribution of radioactive zirconium. 1. Experiments with mice, Gunma J. Med. Sci., 9 Ogawa, 1960, Studies on the excretion and distribution of radioactive zirconium. 2. Experiments with rats, Gunma J. Med. Sci., 9, 212 Ohlenschläger, 1973, Bericht über eine mit Plutonium-239 kontaminierte Riss-Schnittverletzung, Strahlentherapie, 147, 675 Ohlsson, 1962, Penicillamine as lead-chelating substance in man, Br. Med. J., II, 1454, 10.1136/bmj.1.5290.1454 Olcott, 1947, Experimental argyrosis: II. Treatment of rats receiving silver with 2,3-dimercaptopropanol (BAL), Science, 105, 67, 10.1126/science.105.2716.67 Olwin, 1968, Reduction of elevated plasma lipid levels in atheroscerosis following EDTA therapy, 128, 1137 Op de Coul, 1964, Een doot goudintoxicate verwekte psychose, behandeld met D-penicillamine, Ned. T. Geneesk., 108, 465 O'Reilly, 1966, New oral chelating agent for treatment of Wilson's disease, Nature, 212, 1597, 10.1038/2121597a0 Osborn, 1964, Filterable and non-filterable serum copper. (2) Studies with 64Cu, Clin. Sci., 26, 213 Oser, 1963, Safety evaluation studies of calcium EDTA, Tox. appl. Pharmac., 5, 142, 10.1016/0041-008X(63)90039-5 Pagnotto, 1960, Treatment of chronic mercurialism with N-acetyl-penicillamine, Am. Hyg. Ass. J., 21, 419, 10.1080/00028896009344096 Pagnotto, 1957, Oral administration of edathamil calcium disodium (calcium disodium versenate), Archs industr. Hlth., 17, 29 Painter, 1946, Clinical physiology of dogs injected with plutonium, AECD-2042 Palmer, 1970, The uptake, distribution and excretion of promethium in humans and the effect of DTPA on these parameters, Hlth. Phys., 18, 53, 10.1097/00004032-197001000-00005 Parfenov, 1974, Effect of oxathiol on the uptake of absorbed doses from polonium-210 in the rat, Hlth. Phys., 26, 199, 10.1097/00004032-197402000-00005 Parker, 1962, Comparison of retention and organ distribution of Am241 and Cf252 in mice: The effect of in vivo DTPA chelation, Hlth. Phys., 8, 679, 10.1097/00004032-196212000-00017 Pastnitzky, 1951, Die Wirkung von Dimercaptopropanol (BAL) auf die experimentelle Thalliumvergiftung, Act. Dermato-venerol., 31, 331 Peisach, 1969, A mechanism for the action of penicillamine in the treatment of Wilson's disease, Molec. Pharmac., 5, 200 Peñalver, 1957, Diagnosis and treatment of manganese intoxication, Archs industr. Health, 16, 64 Perol, 1962, Effects thérapeutiques de la D-pénicillamine dans trois cas de saturnisme, Sem. Hôp. Paris, 38, 3342 Perry, 1959, Normal concentrations of some trace metals in human urine: Changes produced by ethylenediaminetraacetate, J. clin. Invest., 38, 1452, 10.1172/JCI103922 Perry, 1955, Depression of cholesterol levels in human plasma following ethylenediamine tetracetate and hydralazine, J. Chron. Dis., 2, 520, 10.1016/0021-9681(55)90151-X Perry, 1957, Lesions resembling vitamine B complex deficiency and urinary loss of zinc produced by ethylenediamine tetraacetate, Am. J. Med., 22, 168, 10.1016/0002-9343(57)90349-2 Peters, 1966, Distribution and renal excretion of desferrioxamine and ferrioxamine in the dog and in the rat, Biochem. Pharmac., 15, 93, 10.1016/0006-2952(66)90114-6 Peters, 1945, British anti-lewisite (BAL), Nature, 156, 616, 10.1038/156616a0 Peters, 1947, The use of british anti-lewisite containing radioactive sulphur for metabolism investigations, Biochem. J., 41, 370, 10.1042/bj0410370 Petrović, 1960, Aerosol inhalation of CaNa2E.D.T.A. (Mosatil) by workers constantly exposed poisoning, Br. J. industr. Med., 17, 201 Pfister, 1967, Antidote bei der akuten Eisenvergiftung, Arzneim.-Forsch., 17, 748 Planas-Bohne, 1972, Pharmakokinetische Untersuchungen an 14C-markiertem Penicillamin, Arzneim-Forsch., 22, 1426 Planas-Bohne, 1973, Untersuchungen zur Bilding gemischter Disulfide zwischen D-Penicillamin und Serumproteinen, Res. exp. Med., 161, 289, 10.1007/BF01851452 Planas-Bohne, 1973, On the metabolism of D-penicillamine, Z. Naturfrsch., 28c, 774, 10.1515/znc-1973-11-1226 Planas-Bohne, 1975, Dependence of DTPA toxicity on the treatment schedule, Hlth. Phys., 10.1097/00004032-197507000-00013 Pletscher, 1955, Zur Behandlung der Bleivergiftung mit Calcium-äthylendiamin-tetraacetat, Schweiz. Med. Wschr., 85, 128 Plotnikova, 1964, Deystviye Na3Ca-DTPA (pentatsina) na vyvedeniye Pu239 is organizma cheloveka, Medits. Radiol., 9, 49 Polig, 1973, Compartmental study on the pharmacokinetics of D-penicillamine, Biophysik., 10, 321, 10.1007/BF01194227 Powell, 1966, The assessment of total body iron stores using the chelating agent diethylenetriamine penta-acetic acid (D.T.P.A.), Rev. Med.-chirurg. Malad. Foie, Rate, Pancreas, 41, 271 Powell, 1967, Use of diethylenediamine pentaacetic acid (D.T.P.A.) in the clinical assessment of total body iron stores, J. clin. Path., 20, 896, 10.1136/jcp.20.6.896 Pozza, 1966, Studio del metabolismo glicidico nel tessuto adiposo e nel muscolo in rapporto all'azione di un agente chelante, la desferrioxamina, Acta Diabet. Lat., 3, 381, 10.1007/BF01545400 Prout, 1958, Effect of dimercaprol (BAL) on carbohydrate metabolism, Metabolism, 7, 240 Prpić-Majić, 1962, Učinak različitih terapijskih goza kompleksona EDTA na kliničke i laboratorijske znakove trovanja olovom, Archiv Hig. Rada Toksik., 13, 29 Raab, 1974, Experimentelle Untersuchungen zum Auftreten von Nierenveräderungen unter D-Penicillamin, Int. J. clin. Pharmac., 9, 220 Ragan, 1947, The treatment of gold dermatitides, J. Am. med. Ass., 133, 752, 10.1001/jama.1947.02880110018005 Rahman, 1973, Intracellular plutonium: Removal by liposome-encapsulated chelating agent, Science, 180, 300, 10.1126/science.180.4083.300 Razumovskiy, 1961, Umencheniye otlozheniya v organizme Y91 i Ce144 pri pomoshchi nekotorykh kompleksoobrazovateley, Biofizika, 6, 610 Reuber, 1967, Hepatic lesions in young rats given calcium disodium therapy, Tox. appl. Pharmac., 11, 321, 10.1016/0041-008X(67)90075-0 Reuber, 1967, Severe nephrosis in older male rats given calcium disodium edetate, Arch. Environ. Hlth., 15, 141, 10.1080/00039896.1967.10664894 Reuber, 1969, Calcium disodium edetate nephrosis in female rats of varying ages, J. Path., 97, 335, 10.1002/path.1710970220 Reuber, 1960, Acute versenate nephrosis occuring as the result of treatment for lead intoxication, J. Am. med. Ass., 174, 263, 10.1001/jama.1960.03030030043008 Reuber, 1962, Edetate kidney lesions in rats, Arch. Environ. Hlth., 5, 430, 10.1080/00039896.1962.10663309 Richardson, 1966, Treatment of Wilson's disease, J. Neurosurg., 24, 360 Richmond, 1968, Accelerating the turnover of internally deposited radiocesium, 315 Richmond, 1966, Enhancement of Cesium-137 excretion by rats maintained chronically on ferric ferrocyanide, 121, 664 Richmond, 1964, Hepato-lenticular degeneration (Wilson's disease) treated by penicillamine, Brain, 87, 619, 10.1093/brain/87.4.619 Riede, 1972, Über den Einfluss des Penicillamins auf das Skelettsystem wachsender Ratten, Experientia, 27, 181, 10.1007/BF02145884 Rieders, 1953, Action of dimercaprol and ethylenediamine tetraacetic acid on lead in tissues, 12, 361 Rieders, 1955, Effects of intravenous disodium calcium ethylenediamine tetra-acetate (Na2Ca EDTA) on urinary excreetion of Pb, Fe, Cu and Zn in man, 14, 382 Rieders, 1955, The efficacy of etathamil calcium disodium in the treatment of occupational lead poisoning, Indust. Med. Surg., 24, 195 Rihan, 1967, EDTA and insulin, Diabetologia, 3, 449, 10.1007/BF01228081 Riker, 1946, The treatment of experimental arsenic poisoning with the dithiols, J. Pharmac. exp. Ther., 87, 66 Riker, 1946, The effect of 2,3-dimercaptopropanol (BAL) on the whole blood and plasma concentration of arsenic after mapharsen in cats, J. Pharmac. exp. Ther., 89, 72 Ritter, 1960, Essais et résultats du traitement des manganiques et de la prophylaxie de l'intoxication manganique par L'E.D.T.A. Ca ou calcitétracémate disodique, Arch. Malad. Prof., 21, 115 Ritzmann, 1960, The effect of some mercaptanes upon a macrocryogenglobulin; modifications induced by cysteamine, penicillamine and penicillin, J. clin. Invest., 39, 1320, 10.1172/JCI104149 Rodier, 1954, Étude de l'action détoxicante d l'éthylène-diaminetétraacétate de calcium dans l'intoxication expérimentale par le manganèse, Arch. Malad. Prof., 15, 210 Rosenberg, 1967, Nephrotoxic effects of penicillamine in cystinuria, J. Am. med. Ass., 201, 698, 10.1001/jama.1967.03130090062021 Roseman, 1956, The effect of certain chelating substances (EDTA) upon cholesterol metabolism in the rat, J. clin. Invest., 35, 11, 10.1172/JCI103244 Rosenthal, 1964, Effect of desferrioxamine B-methane sulfonate (DFOM) on removal of plutonium in vitro and in vivo, 117, 749 Rosenthal, 1967, Influence of DTPA therapy on long-term effects of retained monometric plutonium: Comparison with polymeric plutonium, Radiat. Res., 31, 506, 10.2307/3572368 Rosenthal, 1969, Osteosarcomas as related to tissue distribution of monomeric and polymeric plutonium in mice, 371 Rosenthal, 1962, Influence of DTPA therapy on long-term effects of retained plutonium, Hlth. Phys., 8, 741, 10.1097/00004032-196212000-00030 Rosenthal, 1968, Combined reticulo-endothelial stimulation and long-term, intermittent DTPA therapy in poisoning by polymeric plutonium, 403 Rosenthal, 1969, Effective dose of DTPA, spaced at 3 day intervals, in removal of skeletal plutoniu, Hlth. Phys., 16, 806 Rosenthal, 1973, Removal of plutonium from mouse liver by glucan and DTPA, Radiat. Res., 53, 102, 10.2307/3573451 Rosenthal, 1948, Failure of 2,3-dimercaptopropanol (BAL) in treatment of argyria, Arch. Dermat. Syphology, 57, 743, 10.1001/archderm.1948.01520170141017 Roskamp, 1948, Indoxication mercurielle aiquë et BAL, Schweiz. Med. Wschr., 78, 932 Rosoff, 1961, Effect of chelating agents on the removal of yttrium and lanthanum from man, Hlth. Phys., 6, 177, 10.1097/00004032-196109000-00011 Rosoff, 1963, Cesium-137 metabolism in man, Radiat. Res., 19, 643, 10.2307/3571485 Rosoff, 1965, Excretion of zinc-chelates in man, 24, 170 Rothstein, 1951, The relationship of the cell surface to metabolism. VI. The chemical nature of uranium-complex groups of the cell surface, J. cell. comp. Physiol., 38, 245, 10.1002/jcp.1030380209 Rubin, 1960, Discussion remark, 155 Rubin, 1964, The significance of chelation for clinical problems of iron metabolism, 66 Rubin, 1956, Chelating agents in the study of renal absorption of alkaline earth cations, Ann. N.Y. Acad. Sci., 64, 337, 10.1111/j.1749-6632.1956.tb52454.x Rubin, 1960, Synthetic amino acid chelating agents and iron metabolism, Ann. N.Y. Acad. Sci., 88, 450, 10.1111/j.1749-6632.1960.tb20042.x Rubin, 1967, Influence of chelation on gold metabolism in rats, 124, 290 Rukavina, 1957, Scleroderma (acrosclerosis). I. Treatment of three cases of the non-calcific variety by chelation (EDTA), J. Invest. Dermat., 29, 273, 10.1038/jid.1957.37 Ruotolo, 1954, Lead and coproporphyrin excretion of patients treated with EDTA, Archs. industr. Hlth., 9, 205 Ryder, 1947, Influence of dithiopropanol (BAL) on human lead metabolism, Science, 106, 63, 10.1126/science.106.2742.63 Ryder, 1947, The effect of dithiopropanol (BAL) on human lead intoxication, J. Lab. clin. Med., 32, 63 Saita, 1957, Mielogramma ricambio porfirinico sideremia nel saturnismo sotto trattamento con versenato di calcio, Med. Lavoro, 48, 130 Scheinberg, 1960, The long term management of hepatolenticular degeneration (Wilson's disease, Am. J. Med., 29, 316, 10.1016/0002-9343(60)90028-0 Schiffmann, 1970, Spontaneous generation of cross-links in aldehyde-containing collagen, Archs Biochem. Biophys., 138, 226, 10.1016/0003-9861(70)90302-4 Schofield, 1973, A measure of the effectiveness of DTPA chelation therapy in cases of plutonium inhalation and plutonium wounds, Hlth. Phys., 24, 317, 10.1097/00004032-197303000-00007 Schroeder, 1955, Antihypertensive effects of metal binding agents, J. Lab. clin. Med., 46, 416 Schubert, 1947, Treatment of plutonium poisoning by metal displacement, Science, 105, 389, 10.1126/science.105.2728.389 Schubert, 1955, Removal of radioelements from the mammalian body, A. Rev. nucl. Sci., 5, 369, 10.1146/annurev.ns.05.120155.002101 Schubert, 1957, Einige medizinische und biologische Anwendungen von Chelatkomplexen, Chimia, 11, 113 Schubert, 1964, The chemical basis of chelation, 466 Schubert, 1969, Radioelement metabolism and decorporation as influenced by chelation and mixed ligand complexes, 355 Schubert, 1960, Chelating agents in the treatment of poisoning by polymerizable radioelements, Nature, 185, 551, 10.1038/185551a0 Schubert, 1954, Studies on the mechanism of protection by aurintricarboxylic acid in berryllium poisoning II, J. biol. Chem., 208, 359, 10.1016/S0021-9258(18)65654-6 Schubert, 1959, Chemical approaches to the treatment of beryllium poisoning, Archs industr. Hlth., 19, 169 Schubert, 1952, Studies on the mechanism of protection by aurintricarboxylic acid in beryllium poisoning. I, J. biol. Chem., 196, 279, 10.1016/S0021-9258(18)55731-8 Schubert, 1961, Tissue distribution of monomeric and polymeric plutonium as modified by a chelating agent, Radiat. Res., 15, 220, 10.2307/3571253 Schüßler, 1967, Der Abbau der Penicillosäure und Penillosäure zu Penicillamin in vivo, Arzneim.-Forsch., 17, 364 Schwartz, 1966, Studies of the nephrotoxicity of ethylenediaminetetraacetic acid, Biochem. Pharmac., 15, 377, 10.1016/0006-2952(66)90309-1 Schwartz, 1967, Subcellular localization of ethylenediaminetetraacetate in the proximal tubular cell of the rat kidney, Biochem. Pharmac., 16, 2413, 10.1016/0006-2952(67)90226-2 Segewitz, 1972, Liganden- und Isotopenaustausch im System: Serumproteine-Zink-Polyaminopolycarbonsäuren, Z. Naturforsch., 27b, 1370, 10.1515/znb-1972-1117 Seidel, 1970, Metabolismus und Toxizität therapeutischer Chelatbildner. 7. Mitteilung: Blutchemische und hämatologische Screening-Tests, Strahlentherapie, 139, 603 Seidel, 1973, Comparison of the effectiveness of CaDTPA and ZnDTPA in removing 241Am from the rat, Radiat. Res., 54, 304, 10.2307/3573708 Seidel, 1973, A multivariate analysis of Ca-DTPA-effectiveness in removing 241Am from the rat, Z. Naturforsch., 28c, 316, 10.1515/znc-1973-5-615 Seidel, 1974, Removal by DTPA of internally deposited 241Am: A comparative study on rats and Syrian hamsters, J. nucl. Med. Biol., 1, 197, 10.1016/0047-0740(74)90006-0 Seidel, 1970, Totale Plasmaclearance von Na[51Cr-ÄDTA] und Inulin-14C bei Ratten, Experientia, 26, 1325, 10.1007/BF02113007 Seidel, 1972, Removal of internally deposited transuranium elements by Zn-DTPA, Hlth. Phys., 22, 779, 10.1097/00004032-197206000-00037 Seidel, 1963, Dekorporation von Radionukliken (Untersuchungen an Radioruthenium), Strahlentherapie, 122, 595 Seidel, 1971, Effectiveness of Zn-DTPA in removal of plutonium from rats, Int. J. Radiat. Biol., 19, 399, 10.1080/09553007114550531 Selander, 1967, Treatment of lead poisoning, Br. J. industr. Med., 24, 272 Semyonov, 1957, Vliyaniye kompleksonov na povedeniye metallov i izluchateley v organizme. I., Akad. Nauk SSSR, Ural. Filial, Trudy. Inst. Biol., 9, 4 Semyonov, 1957, Vliyaniye kompleksonov na povedeniye metallov i izluchateley v organizme. II., Akad. Nauk SSSR, Ural. Filial, Trudy Inst. Biol., 9, 20 Semyonov, 1966, Dostupnost metalla dlya kompleksona i intensivnost evo vydeleniya, 64 Seven, 1960, Observations on the toxicity of intravenous chelating agents, 95 Seven, 1958, Clinical studies with penicillamine in hepatolenticular degeneration, Clin. Res., 6, 302 Seven, 1959, Clinical studies with penicillamine in hepatolenticular degeneration, Am. J. med. Sci., 237, 49, 10.1097/00000441-195901000-00007 Shiels, 1956, Treatment of lead poisoning by edathamil calcium-disodium, Archs industr. Hlth., 13, 489 Sidbury, 1953, Effect of chelating agent on urinary lead excretion. Comparison of oral and intravenous administration, 82, 226 Siegenthaler, 1960, Der antitoxische Effekt verschiedener Substanzen bei der experimentellen Thalliumvergiftung, Praxis, 49, 633 Sillén, 1964 Sillén, 1971 Simpson, 1950, Biochemical studies of toxic agents. 1. Experiments with radioactive 2:3-dimercaptopropanol (British anti-lewisite), Biochem. J., 46, 634, 10.1042/bj0460634 Sivaramakrishnan, 1962, Influence of chelating agents on the distribution of cobalt-60 in albino rats, Nature, 193, 1195, 10.1038/1931195a0 Sivjakov, 1959, The treatment of acute selenium, cadmium, and tungsten intoxication in rats with calcium disodium ethylenediaminetetraacetate, Tox. appl. Pharmac., 1, 602, 10.1016/0041-008X(59)90064-X Sjöberg, 1951, Health hazards in the production and handling of vanadium pentoxide, Archs industr. Hyg. Occup. Med., 3, 631 Slepička, 1969, Pokus o ovlivněn í vylučování talia D-penicillaminem, Prac. Lékařst., 21, 67 Slobodien, 1973, Removal of zinc from humans by DTPA chelation therapy, Hlth. Phys., 24, 327, 10.1097/00004032-197303000-00008 Slouka, 1969, To the mechanism of enhanced faecal excretion of lanthanous by chelates Smith, 1961, Treatment of inorganic mercury poisoning with N-acetyl-D,L-penicillamine, Lancet, i, 640, 10.1016/S0140-6736(61)91656-7 Smith, 1968, Experiences in the removal of radioactive strontium from animals by modifying physiological parameters, 372 Smith, 1964, The effect of DTPA treatment after administration to rats of 239Pu(VI) in nitric acid, Int. J. Radiat. Biol., 8, 191, 10.1080/09553006414550201 Smith, 1969, Efficiency of low level DTPA therapy in removing plutonium from mice, Nature, 223, 667 Smith, 1962, Iron excretion in thalassaemia major after administration of chelating agents, Br. Med. J., II, 1577, 10.1136/bmj.2.5319.1577 Smith, 1964, Chelating agents in the diagnosis and treatment of iron overload in thalassaemia, Ann. N.Y. Acad. Sci., 119, 776, 10.1111/j.1749-6632.1965.tb54079.x Smith, 1958, Removal of internally deposited plutonium, Nature, 181, 1792, 10.1038/1811792a0 Smith, 1964, Prevention of plutonium deposition by desferrioxamine-B, Nature, 204, 899, 10.1038/204899a0 Smith, 1970, Removal of firmly bound promethium from the rat, BNWL-1050 Smith, 1971, The effect of DTPA dose on plutonium removal from rats, BNWL-1050 Smith, 1972, Therapeutic removal of internally deposited transuranium elements, Hlth. Phys., 22, 765, 10.1097/00004032-197206000-00036 Smith, 1961, Effectiveness of DTPA in removing plutonium from the pig, 107, 120 Spencer, 1964, Effects of chelating agents in man, 34 Spencer, 1965, Removal of scandium-46 in man, Hlth. Phys., 11, 1181, 10.1097/00004032-196511000-00006 Spencer, 1966, Effect of chelating agents on the removal of zinc-65 in man, Hlth. Phys., 12, 475, 10.1097/00004032-196604000-00002 Spencer, 1956, Studies on the effect of ethylenediaminetetraacetic acid in hypercalcemia, J. Lab. clin. Med., 47, 29 Spencer, 1962, Effect of the chelating agent bis 2-aminoethyl ether tetraacetate (BAETA) on radiostrontium excretion in man, J. Lab. clin. Med., 59, 445 Spencer, 1967, Inhibition of radiostrontium absorption in man, Int. J. appl. Radiat. Isotop., 18, 779, 10.1016/0020-708X(67)90016-6 Spencer, 1969, Inhibition of radiostrontium absorption by aluminum phosphate gel in man and its comparative effect on radiocalcium absorption, Int. J. appl. Radiat. Isotop., 20, 507, 10.1016/0020-708X(69)90004-0 Spier, 1952, Tierexperimentelle Studien über die Wirkung von B. A. L. (Sulfactin), “BAL-intrav” und Methionin (Thiomedon) bei letaler Thalliuminotoxication, Arch. Dermat. Syphilis, 194, 225, 10.1007/BF00412179 Spode, 1960, Über den Stoffwechsel von Radio-Quecksilber (203Hg) im Organismus der weißen Maus unter Berücksichtigung von Dekorporationsmaßnahmen, Z. ges. inn. Med. Grenzgeb., 15, 603 Spray, 1947, The effect of injected British anti-lewisite on urinary sulphur and glucuronic acid fractions, Biochem. J., 41, 366, 10.1042/bj0410366 Spray, 1947, Further investigation on the metabolism of 2:3-dimercaptopropanol, Biochem. J., 41, 362, 10.1042/bj0410362 Srbová, 1957, Über die Resorption des Calciumdinatriumsalzes der Äthylendiamintetraessigsäure bei der peroralen Verabreichung zur Therapie der Bleivergiftung, Arch. Gewerbepath. Gewerbehyg., 15, 572 Sroczynski, 1969, Influence de l'administration prophylactique de versénate de calcium disodique sur certains paramèters cliniques et biochimiques chez des ouvriers exposés aus risque de saturnisme, Arch. Malad. Prof., 30, 685 Stacy, 1967, Chromium-51 ethylenediaminetetraacetate for estimation of glomerular filtration rate, Science, 152, 1076, 10.1126/science.152.3725.1076 Stannard, 1956, The effect of BAL (British anti-lewisite) on distribution and excretion of orally administered polonium-210, UR-429 Stara, 1968, Repressive action of sodium alginate on absorption of radioactive strontium and calcium in cats, 340 Stavinoha, 1959, The effects of some sulfur compounds on thallotoxicosis in mice, Toxic. appl. Pharmac., 1, 638, 10.1016/0041-008X(59)90068-7 Sternlieb, 1966, Penicillamine and the nephrotic syndrome, J. Am. med. Ass., 198, 1311, 10.1001/jama.1966.03110250125039 Sternlieb, 1964, Penicillamine therapy for hepatolenticular degeneration, J. Am. med. Ass., 189, 748, 10.1001/jama.1964.03070100042008 Stevens, 1962, Metabolism of the chelating agent diethylenetriamine pentaacetic acid (C14DTPA) in man, 111, 235 Stevens, 1974, Alternate methods for administering chelating agents in decorporation therapy, COO-119-249, 149 Stocken, 1947, British anti-lewisite as an antidote for acute mercury poisoning, Biochem. J., 41, 358, 10.1042/bj0410358 Stocken, 1946, British anti-lewisite. 3, Biochem. J., 40, 548, 10.1042/bj0400548 Stocken, 1949, Reactions of British anti-lewisite with arsenic and other metals in living systems, Physiol. Rev., 29, 168, 10.1152/physrev.1949.29.2.168 Stocken, 1947, British anti-lewisite. 4, Biochem. J., 41, 47, 10.1042/bj0410047 Stover, 1966, The action of chelating agents on 212Pb in the blood: the particular value of the steady state after 228Th administration to the beagle, Int. J. Radiat. Biol., 11, 27, 10.1080/09553006614550761 Strain, 1967, Promotion of radioisotope excretion, J. nucl. Med., 8, 109 Sullivan, 1960, The effects of metallic edetates on the growth and blood formation of rats, Archs int. Pharmacodyn. Thèr., 124, 225 Sulzberger, 1946, Studies on the toxicity of BAL on percutaneous and parenteral administration, J. clin. Invest., 25, 474, 10.1172/JCI101730 Sunderman, 1964, Nickel and copper mobilization by sodium diethyldithiocarbamate, J. New Drugs, 4, 154, 10.1002/j.1552-4604.1964.tb00196.x Sunderman, 1958, Nickel poisoning. VIII. Dithiocarb: a new therapeutic agent for persons exposed to nickel carbonyl, Am. J. med. Sci., 236, 26, 10.1097/00000441-195807000-00003 Sunderman, 1963, Metabolic balance studies in hepatolenticular degeneration treated with diethyldithiocarbamate, Am. J. Med., 34, 875, 10.1016/0002-9343(63)90094-9 Sundin, 1948, B. A. L.-behandling av kronisk blyförgiftning, Sved. Läkart., 45, 905 Sutton, 1967, Reduction of strontium absorption in man by the addition of alginate to the diet, Nature, 216, 1005, 10.1038/2161005a0 Swanberg, 1964, Excretion of Pu239 in a patient with a plutonium-contaminated injury, J. occ. Med., 6, 174 Swanson, 1947, Influence of BAL on the acute toxicity of gold salts in mice, 6, 375 Swenerton, 1971, Teratogenic effects of a chelating agent and their prevention by zinc, Science, 173, 62, 10.1126/science.173.3991.62 Swensson, 1967, Experiments with different antidotes in acute poisoning by different mercury compounds, Int. Arch. Gewerbepath. Gewerbehyg., 24, 12, 10.1007/BF01014660 Tamboline, 1956, Glucosuria in rats receiving British anti-lewisite (BAL), Can. J. Biochem. Physiol., 34, 815, 10.1139/o56-086 Tamir, 1964, Mercury poisoning from an unsuspected source, Br. J. indust. Med., 21, 299 Tarui, 1960, Studies on zinc metabolism. I. The influence of chelating agents on urinary excretion of metals, Med. J. Osaka Univ., 10, 499 Tauxe, 1966, Radiocopper studies in patients with Wilson's disease and their relatives, Am. J. Med., 41, 375, 10.1016/0002-9343(66)90083-0 Taylor, 1967, The effects of desferrioxamine on the retention of actinide elements in the rat, Hlth. Phys., 13, 135, 10.1097/00004032-196702000-00002 Taylor, 1972, Effects of ethylenediaminetetraacetate and diethylenetriaminepentaacetate on DNA synthesis in kidney and intestinal mucosa of folate treated rats, Biochem. Pharmac., 21, 3313, 10.1016/0006-2952(72)90097-4 Taylor, 1962, The removal of americium and plutonium from the rat by chelating agents, Phys. Med. Biol., 7, 83, 10.1088/0031-9155/7/1/306 Taylor, 1974, Increased toxicity of Na3CaDTP when given by protracted administration, Hlth. Phys., 27, 285, 10.1097/00004032-197409000-00007 Taylor, 1955, Growth-promoting activity for pigs of inactivated penicillin, Nature, 176, 312, 10.1038/176312a0 Teisinger, 1958, Über den Einfluß des zur Therapie der Bleivergiftung angewendeten Calciumdinatriumsalzes der Äthylendimaintetraessigsäure auf den Eisenund Kupferspiegel im Blut und Urin, Arch. Gewerbepath. Gewerbehyg., 16, 478, 10.1007/BF00314691 Teisinger, 1956, Léčba chronické otravy olovem vápenatou disodnou solú kyseliny ethylendiaminotetraoctové, Prac. Lékar., 8, 163 Teisinger, 1958, Effect of edathamil calcium-disodium on retention of lead in the liver, Archs industr. Hlth., 17, 302 Thompson, 1967, Desferal therapy in iron storage disease, Am. J. med. Sci., 253, 453 Thompson, 1947, Antidotal activity of British anti-lewisite against compounds of antimony, gold and mercury, Biochem. J., 41, 342, 10.1042/bj0410342 Thyresson, 1950, The influence of dietary factors, especially brewer's yeast, cystine and B vitamins, on the course of chronic thallium poisoning in the rat, Acta Dermat. Venerol., 30, 11 Thyresson, 1951, Experimental investigation on thallium poisoning in the rat, Acta Dermat. Venerol., 31, 3 Timm, 1958, Histochemische Studien zur Ausscheidung des Bleisalzes der Äthylendiamintetraessigsäure durch die Rattenniere, Naunyn Schmiedebergs Arch. exp. Path. Pharmak., 233, 422, 10.1007/BF00246148 Tisman, 1972, Inhibition by penicillamine of DNA and protein synthesis by human bone marrow, 139, 355 Tjernberg, 1957, Roentgenographic and toxicologic studies on lead EDTA, Acta Radiat., 47, 308, 10.3109/00016925709170898 Tobias, 1946, The pathology and therapy with 2,3-dimercaptopropanol (BAL) of experimental Cd poisoning, J. Pharmac. exp. Ther., 87, 102 Tombropoulos, 1964, Review of therapeutic procedures for removal of inhaled radioactive materials, Hlth. Phys., 10, 1251, 10.1097/00004032-196412000-00047 Tombropoulos, 1963, Effect of diethylenetramine-pentaacetic acid and polypropylenoglycolethylene oxide polymer on excretion of inhaled 239PuO2 in dogs, Nature, 198, 703, 10.1038/198703a0 Tombropoulos, 1969, Removal of inhaled 144Ce-144Pr oxide by diethylenetraminepentaacetic acid (DTPA) treatment. I. 144Ce-144Pr oxide prepared by peroxide oxidation, Hlth. Phys., 16, 333, 10.1097/00004032-196903000-00009 Torchinskaya, 1966, 488 Tregubenko, 1960, Vliyaniye kompleksonov na povedeniye metallov i izluchateley v organizme. III, Akad. Nauk SSSP, Ural. Filial., Trudy Inst. Biol., 12, 5 Tregubenko, 1961, Uskoreniye vydeleniya ittriya, tseriya i svintsa iz organizma pri pomoshchi etilendiamintetrauksusnoy, dietilentriaminpentauksusnoy kislot i diaminodietilovovo efira tetrauksusnoy kisloty, Biokhimiya, 26, 177 Tregubenko, 1962, Uskoreniye vydeleniya ittriya, tseriya i svintsa iz organizma pri pomoshchi uramildiatsetata, 1,2-diamintsiklogeksantetraatsetata i polietilenpoliaminopoliatsetata, Radiobiologiya, 2, 200 Tripod, 1964, A pharmacological comparison of the binding of iron and other metals, 503 Tripod, 1962, Aspects pharmacodynamiques de la mobilisation du fer dans l'organisme, Helv. med. Acta, 29, 674 Trnovec, 1964, Učinok kyseliny diethyléntriamínpentaoctovej (DTPA) na rádioeurópium podané potkanom intravenózne, Bratisl. Lekárske Listy, 44, 201 Truhaut, 1966, Recherches dans la série des complexones, Ann. Biol. Clin., 24, 419 Truhaut, 1969, Sur l'efficacité comparée de la desferrioxamine et du D.T.P.A. comme agents de l'élimination du plutonium chez le rat intoxiqué, Arch. Malad. Prof., 27, 669 Tu, 1964, Studies of pyridoxalpenicillamine antagonism in the human, Biochem. Pharmac., 13, 1527, 10.1016/0006-2952(64)90204-7 Tu, 1965, Copper balance studies during the treatment of patients with Wilson's disease, Metabolism, 14, 653, 10.1016/0026-0495(65)90048-X Tuchmann-Duplessis, 1956, Influence d'un corps de chélation l'acide éthylènediaminetétraacétique sur la gestation et le développement foetal du rat, C. r. hebd. Séanc. Acad. Sci., 243, 1064 Turrian, 1956, Die Wirkung des Calcium Dinatriumsalzes der Aethylendiamintetraessigsäure auf die Quecksilber-Intoxikation bei Ratten, Helv. physiol. pharmac. Acta, 14, 50 Tye, 1947, Prevention of reaction to BAL, J. Am. med. Ass., 134, 1477, 10.1001/jama.1947.72880340003006b Ueda, 1960, Intestinal absorption of amino acids. IV., J. Biochem. (Tokyo), 48, 584, 10.1093/oxfordjournals.jbchem.a127206 Uhl, 1953, Effect of ethylenediamine tetraacetic acid on cholesterol metabolism in rabbits, Am. J. clin. Path., 23, 1226, 10.1093/ajcp/23.12.1226 Vaughan, 1953, Use of ethylene diamine tetracetic acid (Versene) for removing fission products from the skeleton, Lancet, ii, 856, 10.1016/S0140-6736(53)90522-4 Vigliani, 1951, The effects of BAL on the metabolism of lead and on the symptomatology in lead intoxication, Br. J. industr. Med., 8, 218 Vitale, 1973, Oral penicillamine therapy for chronic lead poisoning in children, J. Pediat., 83, 1041, 10.1016/S0022-3476(73)80547-5 Vogt, 1957, Nekrotisierende Nephrose nach Behandlung einer subakut-chronischen Bleivergiftung mit Versenat in hohen Dosen, Schweiz. Med. Wschr., 87, 665 Voigt, 1963, Über den Schutzeffekt der Diäthylentriaminpentaessigsäure (DTPA) bei der akuten experimentellen Cadmiumvergiftung, Z. ges. exp. Med., 136, 326, 10.1007/BF02045755 Volf, 1961, First aid after internal radiostrontium contamination using oral barium sulphate, Phys. Med. Biol., 6, 287, 10.1088/0031-9155/6/2/306 Volf, 1964, Retention of 85Sr in rats as influenced by calcium-activated barium sulphate, Int. J. Radiat. Biol., 8, 509, 10.1080/09553006414550621 Volf, 1971, Present position and problems of chelation therapy, 223 Volf, 1971, Intestinal absorption of strontium, 277 Volf, 1973, Dekorporierung von Radionukliden (Untersuchung an Polonium), Strahlentherapie, 145, 101 Volf, 1974, Combined effect of DTPA and citrate on an intramuscular 239Pu deposit in rats, Hlth. Phys., 27, 152 Volf, 1974, Experimental background for prompt treatment with DTPA of 239Pu-contaminated wounds, Hlth. Phys., 27, 273, 10.1097/00004032-197409000-00005 Volf, 1974, Decorporation of 239Pu and 241Am in the rat and hamster by Zn-DTPA, Radiat. Res., 59, 638, 10.2307/3574080 Volf, 1970, The metabolism of calcium and yttrium chelates of EDTA in the rat, Atomkernenergie, 15, 141 Volf, 1971, Distribution of labelled calcium-, yttrium- and chromium-chelates of EDTA in rats, Archs int. Pharmacodyn. Ther, 190, 110 Vorburger, 1969, Vergleichende Studien zwischen den renalen Clearances von Na2-Cr51-äthylendiamin-tetraacetat, Inulin und Natriumthiosulfat beim Menschen, Klin. Wschr., 47, 415, 10.1007/BF01745785 Wacker, 1955, Zum Wirkungsmechanismus der Antibiotica als Wuchsstoffe bei Tieren. 1. Mitteilung: Versuche mit Penicillamin, Arzneim.-Forsch., 5, 702 Wacker, 1956, Zum Wirkungsmechanismus der Antibiotica als Wuchsstoffe bei Tieren. 2. Mitteilung: Versuche mit inaktiviertem Penicillamin und CoSO4, Arzneim.-Forsch., 6, 712 Wacker, 1966, Zum Wirkungsmechanismus von D- und L-Penicillamin, Arzneim.-Forsch., 16, 825 Wade, 1955, Treatment of acute and chronic lead poisoning with disodium calcium versenate, Ann. Intern Med., 42, 251, 10.7326/0003-4819-42-2-251 Walsh, 1964, Desferrioxamine effect on iron excretion in hemochromatosis, Arch. Intern Med., 113, 435, 10.1001/archinte.1964.00280090121020 Walsh, 1965, Iron chelation with deferoxamine in hepatic disease, Gastroenterology, 49, 134, 10.1016/S0016-5085(19)34559-7 Walshe, 1956, Penicillamine, new oral therapy for Wilson's disease, Am. J. Med., 21, 487, 10.1016/0002-9343(56)90066-3 Walshe, 1960, Penicillamine: The pharmacology of a chelating agent, Ann. int. Med., 53, 1090, 10.7326/0003-4819-53-5-1090 Walshe, 1963, Filterable and non-filterable serum copper. (1) The action of penicillamine, Clin. Sci., 25, 405 Walshe, 1964, Endogenous copper clearance in Wilson's disease: A study of the mode of action of penicillamine, Clin. Sci., 26, 461 Walshe, 1965, Effect of penicillamine on serum iron, Archs Dis. Child., 40, 651, 10.1136/adc.40.214.651 Waters, 1945, BAL (British anti-lewisite), Science, 102, 601, 10.1126/science.102.2659.601 Weatherall, 1948, Effects of BAL and BAL glucoside in acute lead acetate poisoning, Br. J. Pharmac., 3, 137 Webb, 1947, The action of British anti-lewisite (BAL) on enzyme systems, Biochem. J., 41, 74, 10.1042/bj0410074 Weber, 1968, Tierexperimentelle Untersuchungen über den Einfluß von Chelaten auf den Stoffwechsel von Zink, KFK-Report, 785 Weber, 1968, Änderungen des Glykogengehaltes in der Niere von Ratten nach Injektionen von Na2[Ca-ÄDTA], Experientia, 24, 703, 10.1007/BF02138325 Weber, 1969, Wirkung von Na3[Ca-DTPA] auf den Glykogengehalt von Niere und Leber der Ratte, Experientia, 25, 509, 10.1007/BF01900789 Weber, 1969, Metabolismus und Toxizität therapeutischer Chelatbildner. 6. Mitteilung: Die histoautoradiographische Lokalisation von ÄDTA in Organen der Ratte, Strahlentherapie, 137, 708 Weber, 1969, Die Schädigung des Darmes durch ÄDTA und DTPA bei der Ratte, Z. ges. exp. Med., 150, 354, 10.1007/BF02044455 Weber, 1970, Über die hydropische Degeneration in der Rattenniere nach Verabfolgung der Chelatbildner Na2[Ca-ÄDTA] und Na3[Ca-DTPA], Virch. Arch. Abt. B Zellpath., 5, 39, 10.1007/BF02893550 Weber, 1970, Decrease of DNA synthesis in duodenal crypt cells of rats treated with Na3(Ca-DTPA), Eur. J. Pharmac., 11, 117, 10.1016/0014-2999(70)90263-3 Wedelstaedt, 1965, Dekorporation von Radionukliden (Untersuchungen über den therapeutischen Index der Triäthylentetraaminhexaessigsäure), Strahlentherapie, 128, 385 Weiner, 1964, Morbus Wilson im Kindesalter, Münch. Med. Wschr., 106, 387 Weinig, 1958, Nil nocere! Gefahren bei der Behandlung der Bleiintoxikation mit Calciumversenat (“Mosatil”, “Komplexon”), Münch. Med. Wsch., 100, 1788 Werner, 1966, Zehn Jahre Penicillamin, Mediz. Klinik, 61, 1827 West, 1958, Nickel poisoning. VII. The therapeutic effectiveness of alkyldithiocarbamates in experimental animals exposed to nickel carbonyl, Am. J. med. Sci., 236, 15, 10.1097/00000441-195807000-00002 West, 1958, Nickel poisoning. VI. Ineffectiveness of calcium disodium ethylenediaminetetraacetic acid, Archs indust. Hlth., 18, 480 Westlin, 1966, Deferoxamine in the treatment of acute iron poisoning, Clin. Pediat., 5, 531, 10.1177/000992286600500907 Westphal, 1969, Die Verteilung der radioaktiven Isotope von Blei, Quecksilber und Zink im Organismus der Ratte unter dem Einfluß von Penicillamin, Penillosäure und Penicillosäure, Inaugural-dissertation Heidelberg 1969 White, 1954, Studies on the mechanism of protection by aurintricarboxylic acid in beryllium poisoning. IV, Archs Biochem. Biophys., 52, 133, 10.1016/0003-9861(54)90094-6 White, 1951, Protection against experimental beryllium poisoning by aurin tricarboxylic acid, J. Pharmac. exp. Ther., 102, 88 Whitten, 1965, Studies in acute iron poisoning. 1. Desferrioxamine in the treatment of acute iron poisoning: Clinical observations, experimental studies, and theoretical considerations, Pediatrics, 36, 322, 10.1542/peds.36.3.322 Whitten, 1966, Studies in acute iron poisoning. II. Further observations on desferrioxamine in the treatment of acute experimental iron poisoning, Pediatrics, 38, 102, 10.1542/peds.38.1.102 Williams, 1962, Oral calcium disodium versenate in treatment of lead poisoning, Br. J. indust. Med., 19, 211 Wilson, 1948, L-Penicillamine as a metabolic antagonist, Science, 107, 653, 10.1126/science.107.2790.653 Wilson, 1950, Inhibition of the growth of the rat by L-penicillamine and its prevention by aminoethanol and related compounds, J. biol. Chem., 184, 63, 10.1016/S0021-9258(19)51123-1 Wintrobe, 1965, Copper metabolism in Wilson's disease, Trans. Ass. Am. Physicians, 67, 232 Wishinsky, 1953, Ethylenediaminetetraacetic acid in the mobilization and removal of iron in a case of hemochromatosis, J. Lab. clin. Med., 42, 550 Wöhler, 1962, Die Therapie der Hämochromatose, Med. Klinik, 57, 1370 Wöhler, 1963, The treatment of haemochromatosis with desferrioxamine, Acta Haemat., 30, 65, 10.1159/000208110 Wolsiefer, 1969, Studies concerning the effect of ferric ferrocyanide, beet pulp, and fluoride upon 137cesium retention in the rat, 130, 953 Wyllie, 1963, Effect of penicillamine in promoting lead excretion, Can. med. Ass. J., 88, 1155 Yefimov, 1967, Ob effektivnosti primeneniya DTPA pri popadanii v organizme radioaktivnykh bariya i lantana, Radiobiologiya, 7, 90 Young, 1946, Canadian researches on BAL (anti-lewisite), Science, 103, 439, 10.1126/science.103.2676.439 Young, 1958, The treatment of exposure to thorium and uranium with a chelating agent and supportive measures, Indust. Med. Surg., 27, 229 Yunice, 1968, Effect of desferrioxamine on trace metals in rat organs, Archs Environ. Hlth., 16, 163, 10.1080/00039896.1968.10665038 Zorn, 1970, Metabolismus und Toxizität therapeutischer Chelatbildner. 9. Mitteilung: Zur Frage der Metabolisierung von ÄDTA und DTPA, Strahlentherapie, 140, 452 Zotova, 1958, Vliyaniye unitiola na vyvedeniye poloniya (Po210) is organizma, Medits. Radiol., 3, 67