Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage

Bekier, 2009, Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit, Mol. Cancer Ther., 8, 1646, 10.1158/1535-7163.MCT-08-1084

Biggins, 2001, The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint, Genes Dev., 15, 3118, 10.1101/gad.934801

Brito, 2006, Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint, Curr. Biol., 16, 1194, 10.1016/j.cub.2006.04.043

Brito, 2008, Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied, J. Cell Biol., 182, 623, 10.1083/jcb.200805072

Burton, 2005, Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box, Mol. Cell, 18, 533, 10.1016/j.molcel.2005.04.022

Cheeseman, 2006, The conserved KMN network constitutes the core microtubule-binding site of the kinetochore, Cell, 127, 983, 10.1016/j.cell.2006.09.039

Choi, 2009, BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis, EMBO J., 28, 2077, 10.1038/emboj.2009.123

Chung, 2003, Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint, Nat. Cell Biol., 5, 748, 10.1038/ncb1022

Clute, 1999, Temporal and spatial control of cyclin B1 destruction in metaphase, Nat. Cell Biol., 1, 82, 10.1038/10049

D'Angiolella, 2003, The spindle checkpoint requires cyclin-dependent kinase activity, Genes Dev., 17, 2520, 10.1101/gad.267603

DeLuca, 2006, Kinetochore microtubule dynamics and attachment stability are regulated by Hec1, Cell, 127, 969, 10.1016/j.cell.2006.09.047

den Elzen, 2001, Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase, J. Cell Biol., 153, 121, 10.1083/jcb.153.1.121

Engelbert, 2008, The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells, Oncogene, 27, 907, 10.1038/sj.onc.1210703

Famulski, 2007, Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores, Curr. Biol., 17, 2143, 10.1016/j.cub.2007.11.037

Gascoigne, 2008, Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs, Cancer Cell, 14, 111, 10.1016/j.ccr.2008.07.002

Ge, 2009, APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation, Cell Cycle, 8, 167, 10.4161/cc.8.1.7606

Hauf, 2003, The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint, J. Cell Biol., 161, 281, 10.1083/jcb.200208092

Hayes, 2006, Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C, Nat. Cell Biol., 8, 607, 10.1038/ncb1410

Hsu, 2002, E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1), Nat. Cell Biol., 4, 358, 10.1038/ncb785

Huang, 2009, Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly, Cancer Cell, 16, 347, 10.1016/j.ccr.2009.08.020

Kimata, 2008, A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment, Mol. Cell, 32, 576, 10.1016/j.molcel.2008.09.023

Kirkpatrick, 2006, Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology, Nat. Cell Biol., 8, 700, 10.1038/ncb1436

Kraft, 2005, The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates, Mol. Cell, 18, 543, 10.1016/j.molcel.2005.04.023

Matyskiela, 2009, Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism, Mol. Cell, 34, 68, 10.1016/j.molcel.2009.02.027

Minshull, 1994, A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts, Cell, 79, 475, 10.1016/0092-8674(94)90256-9

Montero, 2005, Docetaxel for treatment of solid tumours: a systematic review of clinical data, Lancet Oncol., 6, 229, 10.1016/S1470-2045(05)70094-2

Musacchio, 2007, The spindle-assembly checkpoint in space and time, Nat. Rev. Mol. Cell Biol., 8, 379, 10.1038/nrm2163

Nilsson, 2008, The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction, Nat. Cell Biol., 10, 1411, 10.1038/ncb1799

Ohi, 2007, Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1, Mol. Cell, 28, 871, 10.1016/j.molcel.2007.10.003

Orth, 2008, Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate, Mol. Cancer Ther., 7, 3480, 10.1158/1535-7163.MCT-08-0684

Palframan, 2006, Anaphase inactivation of the spindle checkpoint, Science, 313, 680, 10.1126/science.1127205

Peters, 2006, The anaphase promoting complex/cyclosome: a machine designed to destroy, Nat. Rev. Mol. Cell Biol., 7, 644, 10.1038/nrm1988

Qi, 2007, KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome, J. Biol. Chem., 282, 3672, 10.1074/jbc.M609376200

Reddy, 2007, Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation, Nature, 446, 921, 10.1038/nature05734

Schwab, 2001, Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC, EMBO J., 20, 5165, 10.1093/emboj/20.18.5165

Shi, 2008, Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5, Cancer Res., 68, 3269, 10.1158/0008-5472.CAN-07-6699

Sigl, 2009, Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis, J. Cell Sci., 122, 4208, 10.1242/jcs.054197

Stegmeier, 2007, Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities, Nature, 446, 876, 10.1038/nature05694

Stewart, 2005, Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1, Cancer Res., 65, 8730, 10.1158/0008-5472.CAN-05-1500

Thornton, 2006, An architectural map of the anaphase-promoting complex, Genes Dev., 20, 449, 10.1101/gad.1396906

Verma, 2004, Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain, Science, 306, 117, 10.1126/science.1100946

Visconti, 2010, Requirement for proteolysis in spindle assembly checkpoint silencing, Cell Cycle, 9, 564, 10.4161/cc.9.3.10581

Vodermaier, 2003, TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1, Curr. Biol., 13, 1459, 10.1016/S0960-9822(03)00581-5

Welburn, 2010, Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface, Mol. Cell, 38, 383, 10.1016/j.molcel.2010.02.034

Wojcik, 1996, An inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces arrest in G2-phase and metaphase in HeLa cells, Eur. J. Cell Biol., 70, 172

Wolthuis, 2008, Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A, Mol. Cell, 30, 290, 10.1016/j.molcel.2008.02.027

Yu, 2007, Cdc20: a WD40 activator for a cell cycle degradation machine, Mol. Cell, 27, 3, 10.1016/j.molcel.2007.06.009