Pharmacokinetics of isotretinoin and its major blood metabolite following a single oral dose to man

European Journal of Clinical Pharmacology - Tập 24 Số 5 - Trang 689-694 - 1983
Wayne A. Colburn1, Floie M. Vane2, H. J. Shorter3
1Department of Pharmacokinetics and Biopharmaceutics, Hoffmann-La Roche Inc., Nutley, New Jersey, USA
2Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey, USA
3Department of Clinical Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey, USA

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Editorial comment: Vitamin A acid cancer prophylaxis (1976) Brit Med J 2: 2?3

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Khoo K-C, Reik FD, Colburn WA (1982) Pharmacokinetic profile of isotretinoin following a single oral dose of normal man. J Clin Pharmacol 22: 395?402

Vane FM, Stoltenborg JK, Bugge CJL (1982) Determination of 13-cis-retinoic acid and its major metabolite, 4-oxo-13-cis-retinoic acid, in human blood by reverse-phase high-performance liquid chromatography. J Chromatogr 227: 471?484

Boyden EA (1982) An analysis of the reaction of the human gall bladder to food. Anat Rec 40: 147?191