Paraneoplastic cerebellar degeneration as a presentation of breast cancer – a case report and review of the literature
Tóm tắt
Paraneoplastic cerebellar degeneration is part of a rare spectrum of neurological syndromes whereby gynaecological, lung or breast cancers present primarily with neurological manifestations. The presence of onconeural antibodies and PET scanning help in the challenging diagnosis of these conditions but despite the treatment of the primary cancer, the prognosis for the neurological symptoms is poor.
Tài liệu tham khảo
Rojas-Marcos I, Rosseau A, Keime-Guibert F, Ramon R, Cartalat-Carel S, Delattre JY, Graus F: Spectrum of paraneoplastic neurologic disorders in women with breast and gynaecologic cancer. Medicine. 2003, 82 (3): 216-223. 10.1097/00005792-200305000-00007.
Kawasoe T, Yamamoto Y, Okumura Y, Iwase H: A case report of paraneoplastic neurological syndrome associated with occult breast cancer. Breast cancer. 2006, 13 (2): 202-204. 10.2325/jbcs.13.202.
Gatti G, Simsek S, Kurne A, Zurrida S, Naninato P, Veronesi P, Frasson A, Millen E, Rososchansky J, Luini A: Paraneoplastic neurological disorders in breast cancer. The Breast. 2003, 12 (3): 203-207. 10.1016/S0960-9776(03)00011-0.
Dorn C, Knobloch C, Kupka M, Morakkabati-Spitz N, Schmolling : Paraneoplastic neurological syndrome: patient with anti-Yo antibody and breast cancer: a case report. Arch Gynecol Obstet. 2003, 269: 62-65. 10.1007/s00404-002-0416-2.
Mathew RM, Cohen AB, Galetta SL, Alavi A, Dalmau J: Paraneoplastic cerebellar degeneration: Yo-expressing tumour revealed after a 5-year follow-up with FDG-PET. J Neurol Sci. 250 (1–2): 153-155. 2006, Dec 1;
Rubello D, Vitaliani R, Rigoni MT, Rampin L, Giometto B, Casara D, Zonzin GC, Zavagno G, Capirci C, Shapiro B, Muzzio PC: A rare case of paraneoplastic cerebellar degeneration discovered by whole body F-18 FDG PET. Clin Nuc Med. 2005, 30 (10): 704-706. 10.1097/01.rlu.0000178247.44467.f5.
Younes-Mhenni S, Janier MF, Cinotti L, Antoine JC, Tronc F, Cottin V, Ternamian PJ, Trouillas P, Honnorat J: FDG-PET improves tumour detection in patients with paraneoplastic neurological syndromes. Brain. 2004, 127 (10): 2331-2338. 10.1093/brain/awh247.
Rojas I, Graus F, Keime-Guibert F, Rene R, Delattre JY, Ramon JM, Dalmau J, Posner JB: Long term clinical outcome of paraneoplastic cerebellar degeneration and anti-Yo antibodies. Neurology. 2000, 55 (1): 713-715.