Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
Tóm tắt
Từ khóa
Tài liệu tham khảo
Sander, M. & German, M.S. The β-cell transcription factors and development of the pancreas. J. Mol. Med. 75, 327–340 (1997).
Edlund, T., Walker, M.D., Barr, P.J. & Rutter, W.J. Cell specific expression of the rat insulin gene. Science 230, 912–916 (1985).
Stoffers, D.A., Thomas, M.K. & Habener, J.F. The homeodomain protein IDX-1. Trends Endocrinol. & Metab. 8, 145–151 (1997).
Watada, H. et al. The human glucokinase gene β-cell-type promoter. An essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells . Diabetes 45, 1478–1488 (1996).
Miller, C.P., McGehee, R. & Habener, J.F. A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum stimulates somatostatin gene expression in pancreatic islets. EMBO J. 13, 1145– 1156 (1994).
Waeber, G., Thompson, N., Nicod, P. & Bonny, C. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol. Endocrinol. 10, 1327–1333 (1996).
Marshak, S., Totary, H., Cerasi, E. & Melloul, D. Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc. Natl. Acad. Sci. USA 93, 15057–15062 (1996).
Jonsson, J., Carlsson, L., Edlund, T. & Edlund, H. Insulin-promoter-factor-1 is required for pancreas development in mice. Nature 371, 606–609 (1994).
Offield, M.F. et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122, 983–995 (1996).
Stoffers, D.A., Zinkin, N.T., Stanojevic, V., Clarke, W.L. & Habener, J.F. Pancreas agenesis attributable to a single nucleotide deletion in the human IPF-1 gene coding sequence. Nature Genet. 15, 106–110 (1997).
Seijffers, R. et al. Increase in PDX-1 levels supresses insulin gene expression in RIN-38 cells. Endocrinology 140, 3311 –3317 (1999).
Steiner, D.F., Chan, S.J., Welsh, M.J. & Kwok, S.C.M. Structure and evolution of the insulin gene. Annu. Rev. Genet. 19 , 463–484 (1985).
Van-Holde, K.E. Chromatin structure and regulation of gene expression. J. Biol. Chem. 272, 26073 (1997).
Vollenweider, F., Irminger, J.C., Gross, D.J., Villa-Komaroff, L. & Halban, P.A. Processing of proinsulin by transfected hepatoma (FAO) cells. J. Biol. Chem. 267, 14629–14636 (1992).
Steiner, D.F., Smeekens, S.P., Ohagi, S. & Chan, S.J. The new enzymology of precursor processing endopeptidases. J. Biol. Chem. 267, 23435–23438 ( 1992).
O'Doherty, R.M., Lehman, D.L., Telemaque-Potts, S. & Newgard, C.B. Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. Diabetes 48, 2022–2027 ( 1999).
Emens, L.A., Landers, D.W. & Moss, L.G. Hepatocyte nuclear factor 1 α is expressed in a hamster insulinoma line and transactivates the rat insulin I gene. Proc. Natl. Acad. Sci. USA 89, 7300– 7304 (1992).
Lekstrom-Himes, J. & Xanthopoulos, K.G. Biological role of the CCAAT/enhancer-binding protein family of transcription factors . J.Biol. Chem. 273, 28545– 28548 (1998).
Weintraub, H., et al. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc. Natl. Acad. Sci. USA 86, 5434– 5438 (1989).
Heller, R.S., Stoffer, D.A., Hussain, M.A., Miller, C.P. & Habener, J.F. Misexpression of IDX-1 by Hoxa-4 promoter associated with agenesis of the cecum. Gastroenterology 115, 381–3871 ( 1998).
