PI 3-kinase, Akt and cell survival
Tóm tắt
Từ khóa
Tài liệu tham khảo
Yao, 1995, Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor, Science, 267, 2003, 10.1126/science.7701324
Cantley, 2002, The phosphoinositide 3-kinase pathway, Science, 296, 1655, 10.1126/science.296.5573.1655
Khwaja, 1997, Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway, EMBO J., 16, 2783, 10.1093/emboj/16.10.2783
Kauffmann-Zeh, 1997, Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB, Nature, 385, 544, 10.1038/385544a0
Dudek, 1997, Regulation of neuronal survival by the serine-threonine protein kinase Akt, Science, 275, 661, 10.1126/science.275.5300.661
Songyang, 1997, Interleukin 3-dependent survival by the Akt protein kinase, Proc. Natl Acad. Sci. USA, 94, 11345, 10.1073/pnas.94.21.11345
Kulik, 1997, Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt, Mol. Cell. Biol., 17, 1595, 10.1128/MCB.17.3.1595
Scheid, 2003, Unravelling the activation mechanisms of protein kinase B/Akt, FEBS Lett, 546, 108, 10.1016/S0014-5793(03)00562-3
Wei, 2001, Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death, Science, 292, 727, 10.1126/science.1059108
Scorrano, 2003, Mechanisms of cytochrome c release by proapoptotic BCL-2 family members, Biochem. Biophys. Res. Commun., 304, 437, 10.1016/S0006-291X(03)00615-6
Vaux, 2003, Mammalian mitochondrial IAP binding proteins, Biochem. Biophys. Res. Commun., 304, 499, 10.1016/S0006-291X(03)00622-3
Gottlob, 2001, Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase, Genes. Dev., 15, 1406, 10.1101/gad.889901
Yamaguchi, 2001, The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change, Oncogene, 20, 7779, 10.1038/sj.onc.1204984
Kennedy, 1999, Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria, Mol. Cell. Biol., 19, 5800, 10.1128/MCB.19.8.5800
Oren, 2003, Decision making by p53: life, death and cancer, Cell Death Differ., 10, 431, 10.1038/sj.cdd.4401183
Zha, 1996, Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L), Cell, 87, 619, 10.1016/S0092-8674(00)81382-3
Datta, 1997, Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery, Cell, 91, 231, 10.1016/S0092-8674(00)80405-5
Downward, 1999, How BAD phosphorylation is good for survival, Nat. Cell. Biol., 1, E33, 10.1038/10026
Ranger, 2003, Bad-deficient mice develop diffuse large B cell lymphoma, Proc. Natl. Acad. Sci. USA, 100, 9324, 10.1073/pnas.1533446100
Datta, 2002, Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis, Dev. Cell., 3, 631, 10.1016/S1534-5807(02)00326-X
Cardone, 1998, Regulation of cell death protease caspase-9 by phosphorylation, Science, 282, 1318, 10.1126/science.282.5392.1318
Zhou, 2000, Akt regulates cell survival and apoptosis at a postmitochondrial level, J. Cell. Biol., 151, 483, 10.1083/jcb.151.3.483
Brunet, 1999, Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor, Cell, 96, 857, 10.1016/S0092-8674(00)80595-4
Kops, 1999, Direct control of the Forkhead transcription factor AFX by protein kinase B, Nature, 398, 630, 10.1038/19328
Biggs, 1999, Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1, Proc. Natl. Acad. Sci. USA, 96, 7421, 10.1073/pnas.96.13.7421
Ogg, 1997, The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans, Nature, 389, 994, 10.1038/40194
Lin, 1997, Daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans, Science, 278, 1319, 10.1126/science.278.5341.1319
Brunet, 2001, Protein kinase SGK mediates survival signals by phosphorylating the Forkhead transcription factor FKHRL1 (FOXO3a), Mol. Cell. Biol., 21, 952, 10.1128/MCB.21.3.952-965.2001
Dijkers, 2000, Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the Forkhead transcription factor FKHR-L1, Curr. Biol., 10, 1201, 10.1016/S0960-9822(00)00728-4
Mayo, 2001, A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus, Proc. Natl. Acad. Sci. USA, 98, 11598, 10.1073/pnas.181181198
Zhou, 2001, HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation, Nat. Cell. Biol., 3, 973, 10.1038/ncb1101-973
Gottlieb, 2002, Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis, Oncogene, 21, 1299, 10.1038/sj.onc.1205181
Obata, 2000, Peptide and protein library screening defines optimal substrate motifs for AKT/PKB, J. Biol. Chem., 275, 36108, 10.1074/jbc.M005497200
Mayo, 2002, The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network, Trends Biochem. Sci., 27, 462, 10.1016/S0968-0004(02)02166-7
Strano, 2001, Physical interaction with Yes-associated protein enhances p73 transcriptional activity, J. Biol. Chem., 276, 15164, 10.1074/jbc.M010484200
Basu, 2003, Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis, Mol. Cell., 11, 11, 10.1016/S1097-2765(02)00776-1
Berra, 1998, The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway, J. Biol. Chem., 273, 10792, 10.1074/jbc.273.17.10792
Cerezo, 1998, Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation, Mol. Biol. Cell., 9, 3107, 10.1091/mbc.9.11.3107
Okubo, 1998, Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase, J. Biol. Chem., 273, 25961, 10.1074/jbc.273.40.25961
Kim, 2001, Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1, Mol. Cell. Biol., 21, 893, 10.1128/MCB.21.3.893-901.2001
Barthwal, 2003, Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival, J. Biol. Chem., 278, 3897, 10.1074/jbc.M211598200
Kwon, 2000, Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1, J. Biol. Chem., 275, 423, 10.1074/jbc.275.1.423
Kane, 1999, Induction of NF-kappaB by the Akt/PKB kinase, Curr. Biol., 9, 601, 10.1016/S0960-9822(99)80265-6
Ozes, 1999, NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase, Nature, 401, 82, 10.1038/43466
Romashkova, 1999, NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling, Nature, 401, 86, 10.1038/43474
Du, 1998, CREB is a regulatory target for the protein kinase Akt/PKB, J. Biol. Chem., 273, 32377, 10.1074/jbc.273.49.32377
Cross, 1995, Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B, Nature, 378, 785, 10.1038/378785a0
Doble, 2003, GSK-3: tricks of the trade for a multi-tasking kinase, J. Cell. Sci., 116, 1175, 10.1242/jcs.00384
Pap, 1998, Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway, J. Biol. Chem., 273, 19929, 10.1074/jbc.273.32.19929
Rathmell, 2000, In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability, Mol. Cell., 6, 683, 10.1016/S1097-2765(00)00066-6
Edinger, 2002, Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake, Mol. Biol. Cell., 13, 2276, 10.1091/mbc.01-12-0584
Plas, 2001, Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology, J. Biol. Chem., 276, 12041, 10.1074/jbc.M010551200
Vander Heiden, 2001, Growth factors can influence cell growth and survival through effects on glucose metabolism, Mol. Cell. Biol., 21, 5899, 10.1128/MCB.21.17.5899-5912.2001
Rathmell, 2003, Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival, Mol. Cell. Biol., 23, 7315, 10.1128/MCB.23.20.7315-7328.2003
Whiteman, 2002, Role of Akt/protein kinase B in metabolism, Trends Endocrinol. Metab., 13, 444, 10.1016/S1043-2760(02)00662-8
Majewski, 2004, Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases, Mol. Cell. Biol., 24, 730, 10.1128/MCB.24.2.730-740.2004
Pastorino, 2002, Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis, J. Biol. Chem., 277, 7610, 10.1074/jbc.M109950200
Danial, 2003, BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis, Nature, 424, 952, 10.1038/nature01825
Brazil, 2001, Ten years of protein kinase B signalling: a hard Akt to follow, Trends Biochem. Sci., 26, 657, 10.1016/S0968-0004(01)01958-2
Reed, 2002, Keeping p27(Kip1) in the cytoplasm: a second front in cancer’s war on p27, Cell. Cycle, 1, 389, 10.4161/cc.1.6.261
Borgne, 2003, The role of cyclin-dependent kinases in apoptosis, Prog. Cell. Cycle Res., 5, 453