P<scp>AIN</scp> M<scp>ECHANISMS</scp>: Labeled Lines Versus Convergence in Central Processing

Annual Review of Neuroscience - Tập 26 Số 1 - Trang 1-30 - 2003
A.D. Craig1
1Atkinson Pain Research Laboratory, Barrow Neurological Institute, 350 W. Thomas Road, Phoenix, AZ 85013, USA. [email protected]

Tóm tắt

▪ Abstract  The issue of whether pain is represented by specific neural elements or by patterned activity within a convergent somatosensory subsystem has been debated for over a century. The gate control theory introduced in 1965 denied central specificity, and since then most authors have endorsed convergent wide-dynamic-range neurons. Recent functional and anatomical findings provide compelling support for a new perspective that views pain in humans as a homeostatic emotion that integrates both specific labeled lines and convergent somatic activity.

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