Stress oxy hóa trong hen suyễn

World Allergy Organization Journal - Tập 4 - Trang 151-158 - 2011
Umit M Sahiner1,2, Esra Birben1, Serpil Erzurum3,4, Cansin Sackesen1, Omer Kalayci1
1Pediatric Allergy and Asthma Unit, Department of Pediatrics, Turkey
2Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey
3Department of Pathobiology, Lerner Research Institute, USA
4Respiratory Institute, Cleveland Clinic, Cleveland, USA

Tóm tắt

Hen suyễn là một bệnh phổi viêm mãn tính dẫn đến sự hạn chế dòng không khí, tăng phản ứng và tái cấu trúc đường thở. Có bằng chứng mạnh mẽ cho thấy sự mất cân bằng giữa các hệ thống khử và oxy hóa, thiên về trạng thái oxy hóa hơn, xuất hiện trong hen suyễn. Các species oxy phản ứng nội sinh và ngoại sinh, chẳng hạn như anion superoxide, gốc hydroxyl, gốc hypohalite và hydro peroxide, cũng như các species nitơ phản ứng, chẳng hạn như nitric oxide, peroxynitrite và nitrite, đóng vai trò chính trong việc viêm đường thở và là các yếu tố xác định mức độ nghiêm trọng của bệnh hen. Hen suyễn cũng liên quan đến việc giảm khả năng phòng ngừa oxy hóa, chẳng hạn như superoxide dismutase, catalase và glutathione. Trong bài tổng quan này, chúng tôi sẽ tóm tắt kiến thức hiện tại và thảo luận về các chiến lược hiện tại và tương lai cho việc điều chế stress oxy hóa trong hen suyễn.

Từ khóa

#stress oxy hóa #hen suyễn #các species oxy phản ứng #biện pháp phòng ngừa oxy hóa #mức độ nghiêm trọng của hen suyễn

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Thông tin xuất bản

World Allergy Organization Journal

Tập 4

151-158

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