Ovarian cancer antigen CA125 is encoded by the <i>MUC16</i> mucin gene

International Journal of Cancer - Tập 98 Số 5 - Trang 737-740 - 2002
Beatrice W.T. Yin1, Ann M. Dnistrian, Kenneth O. Lloyd
1Immunology Program, Sloan-Kettering Institute, New York, NY 10021, USA.

Tóm tắt

AbstractSerum assays based on the CA125 antigen are widely used in the monitoring of patients with ovarian cancer; however very little is known about the molecular nature of the CA125 antigen. We recently cloned a partial cDNA (designated MUC16) that codes for a new mucin that is a strong candidate for being the CA125 antigen. This assignment has now been confirmed by transfecting a partial MUC16 cDNA into 2 CA125‐negative cell lines and demonstrating the synthesis of CA125 by 3 different assays. Of the 3 antibodies (OC125, M11 and VK‐8) tested on the transfected cells, only the first 2 were strongly positive, indicating the differential expression of the CA125 epitopes in these cells. The cloning and expression of CA125 antigen opens the way to an understanding of its function in normal and malignant cells. © 2002 Wiley‐Liss, Inc.

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Thông tin
Thông tin xuất bản

International Journal of Cancer

Tập 98 Số 5

737-740

Thông tin tác giả