Ludmila Brunerová1, Petra Ronová2, Jana Verešová2, Petra Beranová2, Jana Potoèková1, Petr Kasalický3, Ivan Rychlík1
1II. Internal Department, Faculty Hospital Kralovske Vinohrady, and 3rd Faculty of Medicine, Charles University
2Dialysis Centre, Fresenius Medical Care, Prague-Vinohrady, Czech Republic
3Bone Metabolism Unit, Affidea,Prague
Tóm tắt
<b><i>Background/Aims: </i></b>Small attention is paid to other types of bone diseases then chronic kidney disease-mineral and bone disorder in dialysis patients. The aim of our study was to assess the occurrence of osteoporosis and bone microarchitecture by trabecular bone score in this population. <b><i>Methods: </i></b>59 patients (67.6 ± 13.1 years, 43 males) treated with hemodiafIltration underwent densitometry (Lunar Prodigy, TBS software 2.1.2) and laboratory assessment. <b><i>Results: </i></b>Osteoporosis was observed in 34% patients, high bone turnover was found in 80% of them, with SHPT (PTH > 300 ng/l) present in 69%. TBS was significantly decreased in 47.5% of the patients. TBS correlated with T- and Z-scores of the lumbar spine and proximal femur in the total population (P < 0.0001) and in men (P < 0.00001) and there were significant differences between TBS in groups with normal densitometry, osteopenia, and osteoporosis, both in total population (P < 0.0001; P < 0.01) and in men (P < 0.001; P < 0.001). <b><i>Conclusions: </i></b>Osteoporosis was found in about 1/3 of patients treated with hemodiafiltration. Normal TBS was found in only 1/4 of the dialysis population. TBS correlated with densitometric parameters and was significantly different relative to T-scores.
