Ophthalmic Abnormalities in Children With Down Syndrome

Journal of Pediatric Ophthalmology and Strabismus - Tập 46 Số 2 - Trang 76-82 - 2009
Alexandra L Creavin1, R Brown
1University Hospital of North Staffordshire, Stoke-on-Trent, Staffordshire, United Kingdom.

Tóm tắt

A comprehensive review of the available literature was performed to determine the common ophthalmic disorders in children aged 0 to 16 years with Down syndrome. The UK National Library for Health interface was used to search seven electronic databases, including MEDLINE and EMBASE. Terms related to Down syndrome, ophthalmology, and pediatrics were combined in the search strategy, which yielded 230 articles. Application of exclusion criteria left 23 articles to include in the review. Literature synthesis demonstrated that children with Down syndrome are at risk for several ocular disorders. Refractive error was a common finding, particularly hyperopia. Strabismus was also reported regularly, particularly esodeviation. Other frequent findings included poor visual acuity, nystagmus, and blepharitis, whereas cataract and glaucoma were less common but had potentially serious implications for future vision. Only one study compared routine pediatric examination to that of a pediatric ophthalmologist. The findings of this review confirm the need for an ophthalmic screening program for children with Down syndrome. Additional work should investigate how such a program could be best implemented and ascertain how to involve different professionals in such a service. [J Pediatr Ophthalmol Strabismus 2009;46:76–82.]

Từ khóa


Tài liệu tham khảo

10.1002/mrdd.20162

10.1002/mrdd.20157

Oliver CA. A clinical study of the ocular symptoms found in the so-called Mongolian type of idiocy. Trans Am Ophthalmol Soc. 1891;6:140–148.

10.1016/j.jclinepi.2005.12.010

10.1177/000992288902800804

10.1016/S0002-9394(14)76031-3

10.1177/112067210701700521

10.1016/S0002-9394(14)72015-X

Liza-Sharmini AT, Azian ZN, Zilfalil BA. Ocular findings in Malaysian children with Down syndrome. Singapore Med J. 2006;47:14–19.

10.3109/13816819609057864

10.1111/j.1444-0938.2006.00033.x

10.1016/S0887-8994(97)00029-5

10.1111/j.1469-8749.2007.00513.x

10.1167/iovs.01-0131

Ebeigbe JA, Akpalaba R. Ocular health status of subjects with Down's syndrome in Benin City, Nigeria. African J Med Medical Sci. 2006;35:365–368.

10.1136/bjo.83.10.1112

10.3928/01913913-20060101-03

10.1136/bjo.86.12.1367

10.1097/OPX.0b013e318031b686

10.1038/sj.eye.6700208

10.1111/j.1469-8749.1994.tb11896.x

10.1016/j.arcmed.2003.06.005

10.1016/S0042-6989(96)00304-5

10.3104/reports.105

10.1016/S0161-6420(90)32399-0

10.1111/j.1469-8749.1994.tb11895.x

10.1016/j.ophtha.2006.12.015

10.1038/sj.eye.6702845

10.1055/s-2008-1046023

10.1080/03014460210157394

10.1016/j.tig.2004.06.010

10.1080/08820530701331784

10.1136/bjo.85.3.314

10.1177/0306312703033001311