Of mice and men: divergent risks of teriparatide-induced osteosarcoma

Osteoporosis International - Tập 21 Số 6 - Trang 1041-1045 - 2010
Vivek Subbiah1, Valdemar Madsen1, A. Kevin Raymond2, Robert S. Benjamin1, Joseph A. Ludwig1
1Department of Sarcoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, USA
2Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, USA.

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Tài liệu tham khảo

Services USDoHaH. (U.S. Dept. of Health and Human Services, Office of the Surgeon General). Bone Health and Osteoporosis: A Report of the Surgeon General. 2004.

Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ (2007) Cancer statistics, 2007. CA Cancer J Clin 57(1):43–66

Huvos AG, Butler A, Bretsky SS (1983) Osteogenic sarcoma associated with Paget's disease of bone. A clinicopathologic study of 65 patients. Cancer 52(8):1489–1495

Rosemann M, Kuosaite V, Nathrath M, Atkinson MJ (2002) The genetics of radiation-induced and sporadic osteosarcoma: a unifying theory? J Radiol Prot 22(3A):A113–A116

Vahle JL, Sato M, Long GG et al (2002) Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1–34) for 2 years and relevance to human safety. Toxicol Pathol 30(3):312–321

Vahle JL, Long GG, Sandusky G, Westmore M, Ma YL, Sato M (2004) Bone neoplasms in F344 rats given teriparatide [rhPTH(1–34)] are dependent on duration of treatment and dose. Toxicol Pathol 32(34):426–438

Harper KD, Krege JH, Marcus R, Mitlak BH (2006) Comments on initial experience with teriparatide in the United States. Curr Med Res Opin 22(10):1927

Harper KD, Krege JH, Marcus R, Mitlak BH (2007) Osteosarcoma and teriparatide? J Bone Miner Res 22(2):334

Burr DB, Hirano T, Turner CH, Hotchkiss C, Brommage R, Hock JM (2001) Intermittently administered human parathyroid hormone(1–34) treatment increases intracortical bone turnover and porosity without reducing bone strength in the humerus of ovariectomized cynomolgus monkeys. J Bone Miner Res 16(1):157–165

Dempster DW, Cosman F, Parisien M, Shen V, Lindsay R (1993) Anabolic actions of parathyroid hormone on bone. Endocr Rev 14(6):690–709

Jolette J, Wilker CE, Smith SY et al (2006) Defining a noncarcinogenic dose of recombinant human parathyroid hormone 1–84 in a 2-year study in Fischer 344 rats. Toxicol Pathol 34(7):929–940

Divieti P, Geller AI, Suliman G, Juppner H, Bringhurst FR (2005) Receptors specific for the carboxyl-terminal region of parathyroid hormone on bone-derived cells: determinants of ligand binding and bioactivity. Endocrinology 146(4):1863–1870

Tashjian AH, Gagel RF (2006) Teriparatide [human PTH(1–34)]: 2.5 years of experience on the use and safety of the drug for the treatment of osteoporosis. J Bone Miner Res 21(3):388–365