Béo phì, tiểu đường loại 2 và ung thư: kết nối insulin và IGF

Endocrine-Related Cancer - Tập 19 Số 5 - Trang F27-F45 - 2012
Dara Cohen1, Derek LeRoith1
1Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA

Tóm tắt

Các nghiên cứu dịch tễ học cho thấy có mối liên hệ tích cực giữa béo phì và bệnh tiểu đường loại 2 (T2D) với nguy cơ ung thư và tử vong liên quan đến ung thư. Kháng insulin, tăng insulin huyết, mức IGF tăng cao, nồng độ hormone steroid và peptide cao cũng như các yếu tố viêm có vẻ như đóng vai trò trong mối liên hệ giữa những bệnh này. Các loại thuốc như metformin và insulin ngoại sinh, được sử dụng để điều trị T2D, có thể ảnh hưởng đến nguy cơ ung thư và tử vong liên quan đến ung thư. Các liệu pháp mới nhắm vào hệ thống insulin và IGF1 đang được phát triển để sử dụng trong liệu pháp điều trị ung thư.

Từ khóa

#béo phì; bệnh tiểu đường loại 2; ung thư; insulin; IGF

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