Obesity and Dyslipidemia

2002, Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report, Circulation, 106, 3143, 10.1161/circ.106.25.3143 Alberti, 2005, The metabolic syndrome—a new worldwide definition, Lancet, 366, 1059, 10.1016/S0140-6736(05)67402-8 Alberti, 1998, Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation, Diabet Med, 15, 539, 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S Mokdad, 2003, Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001, JAMA, 289, 76, 10.1001/jama.289.1.76 Ford, 2005, Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S, Diabetes Care, 28, 2745, 10.2337/diacare.28.11.2745 Bibbins-Domingo, 2007, Adolescent overweight and future adult coronary heart disease, N Engl J Med, 357, 2371, 10.1056/NEJMsa073166 Kelishadi, 2007, Childhood overweight, obesity, and the metabolic syndrome in developing countries, Epidemiol Rev, 29, 62, 10.1093/epirev/mxm003 Castelli, 1998, Lipoproteins and cardiovascular disease: biological basis and epidemiological studies, Value Health, 1, 105, 10.1046/j.1524-4733.1998.120105.x Ansell, 2005, High-density lipoprotein function: recent advances, J Am Coll Cardiol, 46, 1792, 10.1016/j.jacc.2005.06.080 Onat, 2006, Plasma triglycerides, an independent predictor of cardiovascular disease in men: a prospective study based on a population with prevalent metabolic syndrome, Int J Cardiol, 108, 89, 10.1016/j.ijcard.2005.06.056 Bansal, 2007, Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women, JAMA, 298, 309, 10.1001/jama.298.3.309 Jacobson, 2007, Hypertriglyceridemia and cardiovascular risk reduction, Clin Ther, 29, 763, 10.1016/j.clinthera.2007.05.002 Abdel-Maksoud, 2002, The complex role of triglycerides in cardiovascular disease, Semin Vasc Med, 2, 325, 10.1055/s-2002-35403 Sobenin, 1996, Atherogenic modified LDL in diabetes, Diabetes, 45, S35, 10.2337/diab.45.3.S35 Goldberg, 1996, Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis, J Lipid Res, 37, 693, 10.1016/S0022-2275(20)37569-6 Merkel, 2002, Lipoprotein lipase: genetics, lipid uptake, and regulation, J Lipid Res, 43, 1997, 10.1194/jlr.R200015-JLR200 Horton, 2002, SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver, J Clin Invest, 109, 1125, 10.1172/JCI0215593 Taskinen, 2003, Diabetic dyslipidaemia: from basic research to clinical practice, Diabetologia, 46, 733, 10.1007/s00125-003-1111-y Ginsberg, 2000, Insulin resistance and cardiovascular disease, J Clin Invest, 106, 453, 10.1172/JCI10762 Arner, 2005, Human fat cell lipolysis: biochemistry, regulation and clinical role, Best Pract Res Clin Endocrinol Metab, 19, 471, 10.1016/j.beem.2005.07.004 Kraemer, 2002, Hormone-sensitive lipase: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis, J Lipid Res, 43, 1585, 10.1194/jlr.R200009-JLR200 Adiels, 2005, Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia, Arterioscler Thromb Vasc Biol, 25, 1697, 10.1161/01.ATV.0000172689.53992.25 Ginsberg, 2006, Metabolic syndrome: focus on dyslipidemia, Obes Res, 14, 10.1038/oby.2006.281 Lewis, 1997, Fatty acid regulation of very low density lipoprotein production, Curr Opin Lipidol, 8, 146, 10.1097/00041433-199706000-00004 Qureshi, 2007, Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease, World J Gastroenterol, 13, 3540, 10.3748/wjg.v13.i26.3540 Angulo, 2001, Treatment of nonalcoholic fatty liver: present and emerging therapies, Semin Liver Dis, 21, 81, 10.1055/s-2001-12931 Abrams, 2004, Portal fibrosis and hepatic steatosis in morbidly obese subjects: a spectrum of nonalcoholic fatty liver disease, Hepatology, 40, 475, 10.1002/hep.20323 Yamashita, 2001, A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver, Proc Natl Acad Sci U S A, 98, 9116, 10.1073/pnas.161284298 Arai, 1994, Increased plasma cholesteryl ester transfer protein in obese subjects. A possible mechanism for the reduction of serum HDL cholesterol levels in obesity, Arterioscler Thromb, 14, 1129, 10.1161/01.ATV.14.7.1129 Radeau, 1995, Cholesteryl ester transfer protein (CETP) mRNA abundance in human adipose tissue: relationship to cell size and membrane cholesterol content, J Lipid Res, 36, 2552, 10.1016/S0022-2275(20)41091-0 Dullaart, 1994, Effect of adiposity on plasma lipid transfer protein activities: a possible link between insulin resistance and high density lipoprotein metabolism, Eur J Clin Invest, 24, 188, 10.1111/j.1365-2362.1994.tb00987.x Lewis, 1997, Clearance of postprandial and lipolytically modified human HDL in rabbits and rats, J Lipid Res, 38, 1771, 10.1016/S0022-2275(20)37152-2 Rashid, 2002, The mechanism of HDL lowering in hypertriglyceridemic, insulin-resistant states, J Diabet Complications, 16, 24, 10.1016/S1056-8727(01)00191-X Horowitz, 1993, Increased plasma and renal clearance of an exchangeable pool of apolipoprotein A-I in subjects with low levels of high density lipoprotein cholesterol, J Clin Invest, 91, 1743, 10.1172/JCI116384 de Souza, 2008, Metabolic syndrome features small, apolipoprotein A-I-poor, triglyceride-rich HDL3 particles with defective anti-apoptotic activity, Atherosclerosis, 197, 84, 10.1016/j.atherosclerosis.2007.08.009 Yu, 2005, Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue, Circ Res, 96, 1042, 10.1161/01.RES.0000165803.47776.38 Ahima, 2006, Adipose tissue as an endocrine organ, Obes Res, 14, 242S, 10.1038/oby.2006.317 Wellen, 2003, Obesity-induced inflammatory changes in adipose tissue, J Clin Invest, 112, 1785, 10.1172/JCI20514 Bluher, 2002, Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance, Dev Cell, 3, 25, 10.1016/S1534-5807(02)00199-5 Zhang, 1997, Crystal structure of the obese protein Ieptin-E100, Nature, 387, 206, 10.1038/387206a0 Ahima, 2000, Leptin regulation of neuroendocrine systems, Front Neuroendocrinol, 21, 263, 10.1006/frne.2000.0197 Farooqi, 1999, Effects of recombinant leptin therapy in a child with congenital leptin deficiency, N Engl J Med, 341, 879, 10.1056/NEJM199909163411204 Halaas, 1995, Weight-reducing effects of the plasma protein encoded by the obese gene, Science, 269, 543, 10.1126/science.7624777 Oral, 2002, Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy, J Clin Endocrinol Metab, 87, 3110, 10.1210/jc.87.7.3110 Flier, 2004, Obesity wars: molecular progress confronts an expanding epidemic, Cell, 116, 337, 10.1016/S0092-8674(03)01081-X Pajvani, 2003, Adiponectin: systemic contributor to insulin sensitivity, Curr Diab Rep, 3, 207, 10.1007/s11892-003-0065-2 Berg, 2002, ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism, Trends Endocrinol Metab, 13, 84, 10.1016/S1043-2760(01)00524-0 Yamamoto, 2002, Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population, Clin Sci, 103, 137, 10.1042/CS20010336 Cote, 2005, Adiponectinemia in visceral obesity: impact on glucose tolerance and plasma lipoprotein and lipid levels in men, J Clin Endocrinol Metab, 90, 1434, 10.1210/jc.2004-1711 Martin, 2005, The relationships of adiponectin with insulin and lipids are strengthened with increasing adiposity, J Clin Endocrinol Metab, 90, 4255, 10.1210/jc.2005-0019 Steppan, 2001, The hormone resistin links obesity to diabetes, Nature, 409, 307, 10.1038/35053000 Kojima, 1999, Ghrelin is a growth-hormone-releasing acylated peptide from stomach, Nature, 402, 656, 10.1038/45230 Fan, 1997, Role of melanocortinergic neurons in feeding and the agouti obesity syndrome, Nature, 385, 165, 10.1038/385165a0 Batterham, 2004, Physiology: does gut hormone PYY3-36 decrease food intake in rodents?, Nature, 430, 3, 10.1038/nature02666 Ollmann, 1997, Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein, Science, 278, 135, 10.1126/science.278.5335.135 Cowley, 2003, The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis, Neuron, 37, 649, 10.1016/S0896-6273(03)00063-1 Loftus, 2000, Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors, Science, 288, 2379, 10.1126/science.288.5475.2379 Lam, 2007, Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins, Nat Med, 13, 171, 10.1038/nm1540