Nutritional and intestinal effects of the novel immunosuppressive agents: Deoxyspergualin, rapamycin, and mycophenolate mofetil

Sigalet, 1991, Cyclosporin reduces nutrient absorption by normal bowel, Clin Res, 39, 18A Sigalet, 1991, The effects of Cyclosporine on normal bowel, Transplantation, 51, 1296, 10.1097/00007890-199106000-00028 Collin, 1987, Segmental small intestinal allografts: II. Inadequate function with Cyclosporine immunosuppression: Evidence of a protein-losing enteropathy, Transplantation, 479, 10.1097/00007890-198710000-00004 Todo, 1995, Abdominal multivisceral transplantation, Transplantation, 49, 234, 10.1097/00007890-199501270-00015 Todo, 1993, Clinical intestinal transplantation: three-year experience Fung, 1991, Adverse effects associated with the use of FK506, 23, 3105 Reding, 1994, Conversion from cyclosporine to FK506 for salvage of immunocompromised pediatric liver allografts, Transplantation, 57, 93, 10.1097/00007890-199401000-00017 Madsen, 1995, FK506 increases permeability in rat small intestine by inhibiting mitochondrial function, Gastroenterology, 109, 107, 10.1016/0016-5085(95)90274-0 Yanchar NL, Reigel T, Martin G, et al. Tacrolimus (FK506) — its effects on intestinal glucose transport. Transplantation (in press). Bumgardner, 1993, New immunosuppressive agents, Adv Liver Transplant, 22, 421 Dumont, 1990, The immunosuppressive macrolides FK506 and rapamycin act as reciprocal antagonists in murine T-cells, J Immunol, 144, 1418, 10.4049/jimmunol.144.4.1418 Yuh, 1993, The immunopharmacology of immunosuppression by 15-deoxyspergualin, Transplantation, 55, 578, 10.1097/00007890-199303000-00023 Allison, 1993, Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil, Immunol Rev, 136, 5, 10.1111/j.1600-065X.1993.tb00652.x Eugui, 1991, Lymphocyte-selective antiproliferative and immunosuppressive effects on mycophenolic acid in mice, Scand J Immunol, 33, 175, 10.1111/j.1365-3083.1991.tb03747.x Platz, 1991, RS-61433—a new, potent immunosuppressive agent, Transplantation, 51, 27, 10.1097/00007890-199101000-00003 Deierhoi, 1993, One-year follow-up results of a phase I trial of Mycophenolate Mofetil (MM) in cadaveric renal transplantation, 25, 693 Calne, 1989, Rapamycin for immunosuppression in organ allografting, Lancet, 2, 227, 10.1016/S0140-6736(89)90417-0 Chen, 1991, The effect of rapamycin on orthotopic small bowel transplantation in the rat, 24, 1157 Todo, 1988, Effect of 15-deoxyspergualin on experimental organ transplantation, 20, 233 Takahara, 1993, Use of 15-Deoxysperguahn in treatment of acute rejection in kidney transplant patients, 25, 2254 D'Alessandro, 1993, Prolongation of canine intestinal allograft survival with RS-61443, Cyclosporine, and Prednisone, Transplantation, 55, 695, 10.1097/00007890-199304000-00002 Sigalet, 1992, Reduction of nutrient absorption in normal rats by cyclosporin, Transplantation, 53, 264, 10.1097/00007890-199202010-00003 Sigalet DL, Kneteman NM, Fedorak RN, et al. Small intestinal function following syngeneic transplantation in the rat. Journal of Surgical Research (in press). Langman, 1995, Pharmacodynamic assessment of mycophenolic acid-induced immunosuppression by measuring IMP dehydrogenase activity, Clinical Chemistry, 41, 295, 10.1093/clinchem/41.2.295 Granger, 1995, Prolongation of renal allograft survival in a large animal model by oral rapamycin monotherapy, Transplantation, 59, 185, 10.1097/00007890-199501000-00005 Association of Official Analytical Chemist, 1986 Folch, 1956, A simple method for the isolation and purification of total lipids from animal tissues, J Biol Chem, 226, 497, 10.1016/S0021-9258(18)64849-5 Elia, 1987, Evaluation of mannitol, lactulose and 51Cr-labelled ethylenediaminetetra-acetate as markers of intestinal permeability in man, Clin Sci, 73, 197, 10.1042/cs0730197 Sigalet, 1992, Intestinal permeability after small intestinal transplantation and cyclosporine treatment, 24, 1120 Loebl, 1985 Field, 1971, Ion transport in rabbit ileal mucosa. I, Na and Cl fluxes and short-circuit current, Am J Physiol, 220, 1388, 10.1152/ajplegacy.1971.220.5.1388 Fedorak, 1987, Intestinal adaptation to diabetes: Altered Na-dependent nutrient absorption in streptozocin-treated chronically diabetic rats, J Clin Invest, 79, 1571, 10.1172/JCI112991 Fischer, 1991, Metabolism in surgical patients: Protein, carbohydrate and fat utilization by oral and parenteral routes, 103 Yanchar, 1994, Advances in small bowel transplantation: Effects of novel immunosuppressive agents on growth, nutrition and small bowel function in normal rats Morice, 1993, Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T-lymphocytes, J Biol Chem, 268, 3734, 10.1016/S0021-9258(18)53755-8 Jayaraman, 1993, Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line, J Biol Chem, 268, 25385, 10.1016/S0021-9258(19)74403-2 Chung, 1992, Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases, Cell, 69, 1227, 10.1016/0092-8674(92)90643-Q Francavilla, 1992, Inhibition of liver, kidney, and intestine regeneration by Rapamycin, Transplantation, 53, 296