Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin
Tóm tắt
Từ khóa
Tài liệu tham khảo
Ackermann, 2001, De novo synthesis of RNA by the dengue virus RNA-dependent RNA polymerase exhibits temperature dependence at the initiation but not elongation phase, J. Biol. Chem., 276, 39926, 10.1074/jbc.M104248200
Alvisi, 2008, Nuclear import of HSV-1 DNA polymerase processivity factor UL42 is mediated by a C-terminally located bipartite nuclear localization signal, Biochemistry, 47, 13764, 10.1021/bi800869y
Bartholomeusz, 1993, Synthesis of dengue virus RNA in vitro: initiation and the involvement of proteins NS3 and NS5, Arch. Virol., 128, 111, 10.1007/BF01309792
Brooks, 2002, The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals, J. Biol. Chem., 277, 36399, 10.1074/jbc.M204977200
Caly, 2012, Nuclear trafficking of proteins from RNA viruses: potential target for antivirals?, Antiviral Res., 95, 202, 10.1016/j.antiviral.2012.06.008
Chan, 2012, A human PrM antibody that recognizes a novel cryptic epitope on dengue E glycoprotein, PLoS One, 7, e33451, 10.1371/journal.pone.0033451
Egloff, 2002, An RNA cap (nucleoside-2′-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization, EMBO J., 21, 2757, 10.1093/emboj/21.11.2757
Fontes, 2003, Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha, J. Biol. Chem., 278, 27981, 10.1074/jbc.M303275200
Fornerod, 1997, CRM1 is an export receptor for leucine-rich nuclear export signals, Cell, 90, 1051, 10.1016/S0092-8674(00)80371-2
Forwood, 1999, The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site, Biochem. Biophys. Res. Commun., 257, 731, 10.1006/bbrc.1999.0370
Fraser, J.E., Wagstaff, K.M., Jans, D.A., 2013. Method of viral inhibition. Provisional patent filed 16 April, 2013, Australia. 2013901525.
Kapoor, 1995, Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5, J. Biol. Chem., 270, 19100, 10.1074/jbc.270.32.19100
Kumar, 2013, Nuclear localization of dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling, J. Virol., 87, 4545, 10.1128/JVI.03083-12
la Cour, 2004, Analysis and prediction of leucine-rich nuclear export signals, Protein Eng. Des. Sel., 17, 527, 10.1093/protein/gzh062
Lindenbach, 2007
Mastrangelo, 2012, Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug, J. Antimicrob. Chemother., 67, 1884, 10.1093/jac/dks147
Medin, 2005, Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion, J. Virol., 79, 11053, 10.1128/JVI.79.17.11053-11061.2005
Moreland, 2012, Monoclonal antibodies against dengue NS2B and NS3 proteins for the study of protein interactions in the flaviviral replication complex, J. Virol. Methods, 179, 97, 10.1016/j.jviromet.2011.10.006
Moseley, 2009, Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response, J. Cell Sci., 122, 3652, 10.1242/jcs.045542
Omura, 2008, Ivermectin: 25 years and still going strong, Int. J. Antimicrob Agents, 31, 91, 10.1016/j.ijantimicag.2007.08.023
Pryor, 2007, Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection, Traffic, 8, 795, 10.1111/j.1600-0854.2007.00579.x
Rathore, 2011, Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model, Antiviral Res., 92, 453, 10.1016/j.antiviral.2011.10.002
Rawlinson, 2009, CRM1-mediated nuclear export of dengue virus RNA polymerase NS5 modulates interleukin-8 induction and virus production, J. Biol. Chem., 284, 15589, 10.1074/jbc.M808271200
Robbins, 1991, Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence, Cell, 64, 615, 10.1016/0092-8674(91)90245-T
Takahashi, 2012, Establishment of a robust dengue virus NS3-NS5 binding assay for identification of protein-protein interaction inhibitors, Antiviral Res., 96, 305, 10.1016/j.antiviral.2012.09.023
Tan, 1996, Recombinant dengue type 1 virus NS5 protein expressed in Escherichia coli exhibits RNA-dependent RNA polymerase activity, Virology, 216, 317, 10.1006/viro.1996.0067
Wagstaff, 2006, Intramolecular masking of nuclear localization signals: analysis of importin binding using a novel AlphaScreen-based method, Anal. Biochem., 348, 49, 10.1016/j.ab.2005.10.029
Wagstaff, 2009, Importins and beyond: non-conventional nuclear transport mechanisms, Traffic, 10, 1188, 10.1111/j.1600-0854.2009.00937.x
Wagstaff, 2011, An AlphaScreen(R)-based assay for high-throughput screening for specific inhibitors of nuclear import, J. Biomol. Screen., 16, 192, 10.1177/1087057110390360
Wagstaff, 2012, Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus, Biochem. J., 443, 851, 10.1042/BJ20120150
Wang, 2009, A small-molecule dengue virus entry inhibitor, Antimicrob. Agents Chemother., 53, 1823, 10.1128/AAC.01148-08
Yap, 2010, Crystal structure of the dengue virus methyltransferase bound to a 5′-capped octameric RNA, PLoS One, 5
Yap, 2007, Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution, J. Virol., 81, 4753, 10.1128/JVI.02283-06