Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Lancet Diabetes and Endocrinology,The - Tập 6 Số 5 - Trang 361-369 - 2018
Emma Ahlqvist1, Petter Storm1, Annemari Käräjämäki2,3, Mats Martinell4, Mozhgan Dorkhan1, Annelie Carlsson5, Petter Vikman1, Rashmi B. Prasad1, Dina Mansour Aly1, Peter Almgren1, Ylva Wessman1, Nael Shaat1, Peter Spégel6,1, Hindrik Mulder1, Eero Lindholm1, Olle Melander1, Ola Hansson1, Ulf Malmqvist7, Åke Lernmark1, Kaj Lahti2,3, Tom Forsén8, Jaakko Tuomilehto9,10,8, Anders H. Rosengren11,1, Leif Groop10,1
1Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
2Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland
3Diabetes Center, Vaasa Health Care Center, Vaasa, Finland
4Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
5Lund University Diabetes Centre, Department of Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden
6Department of Chemistry, Centre for Analysis and Synthesis, Lund University, Lund, Sweden
7Clinical Research and Trial Center, Lund University Hospital, Sweden
8Folkhälsan Research Center, Helsinki, Finland
9Abdominal Center, Endocrinology, Helsinki University Central Hospital, Research Program for Diabetes and Obesity, University of Helsinki, Helsinki, Finland
10Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland
11Department of Neuroscience and Physiology, Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden

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Tài liệu tham khảo

2016, Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants, Lancet, 387, 1513, 10.1016/S0140-6736(16)00618-8

Tuomi, 1993, Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease, Diabetes, 42, 359, 10.2337/diab.42.2.359

Froguel, 1993, Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus, N Engl J Med, 328, 697, 10.1056/NEJM199303113281005

Yamagata, 1996, Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3), Nature, 384, 455, 10.1038/384455a0

Reddy, 2015, Epigenetic mechanisms in diabetic complications and metabolic memory, Diabetologia, 58, 443, 10.1007/s00125-014-3462-y

Brownlee, 2005, The pathobiology of diabetic complications: a unifying mechanism, Diabetes, 54, 1615, 10.2337/diabetes.54.6.1615

Pearson, 2006, Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations, N Engl J Med, 355, 467, 10.1056/NEJMoa061759

Lindholm, 2001, Classifying diabetes according to the new WHO clinical stages, Eur J Epidemiol, 17, 983, 10.1023/A:1020036805655

Manjer, 2001, The Malmo Diet and Cancer study: representativity, cancer incidence and mortality in participants and non-participants, Eur J Cancer Prev, 10, 489, 10.1097/00008469-200112000-00003

Rahmati, 2008, A comparison of serum and EDTA plasma in the measurement of glutamic acid decarboxylase autoantibodies (GADA) and autoantibodies to islet antigen-2 (IA-2A) using the RSR radioimmunoassay (RIA) and enzyme linked immunosorbent assay (ELISA) kits, Clin Lab, 54, 227

Tuomi, 1999, Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies, Diabetes, 48, 150, 10.2337/diabetes.48.1.150

Vaziri-Sani, 2011, A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes, J Immunol Methods, 371, 25, 10.1016/j.jim.2011.06.011

Almgren, 2017, Genetic determinants of circulating GIP and GLP-1 concentrations, JCI insight, 2, 93306, 10.1172/jci.insight.93306

Levey, 2009, A new equation to estimate glomerular filtration rate, Ann Intern Med, 150, 604, 10.7326/0003-4819-150-9-200905050-00006

Martinell, 2016, Prevalence and risk factors for diabetic retinopathy at diagnosis (DRAD) in patients recently diagnosed with type 2 diabetes (T2D) or latent autoimmune diabetes in the adult (LADA), J Diabetes Complications, 30, 1456, 10.1016/j.jdiacomp.2016.08.009

Levy, 1998, Correct homeostasis model assessment (HOMA) evaluation uses the computer program, Diabetes Care, 21, 2191, 10.2337/diacare.21.12.2191

Hennig, 2007, Cluster-wise assessment of cluster stability, Comput Stat Data An, 52, 258, 10.1016/j.csda.2006.11.025

Marchini, 2007, A new multipoint method for genome-wide association studies by imputation of genotypes, Nat Genet, 39, 906, 10.1038/ng2088

Prasad, 2015, Genetics of type 2 diabetes—pitfalls and possibilities, Genes, 6, 87, 10.3390/genes6010087

Lyssenko, 2007, Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes, J Clin Invest, 117, 2155, 10.1172/JCI30706

Liu, 2014, TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease, Nat Commun, 5, 4309, 10.1038/ncomms5309

Nguyen, 2013, Definition of high-risk type 1 diabetes HLA-DR and HLA-DQ types using only three single nucleotide polymorphisms, Diabetes, 62, 2135, 10.2337/db12-1398

Li, 2015, Identification of type 2 diabetes subgroups through topological analysis of patient similarity, Sci Transl Med, 7, 311ra174, 10.1126/scitranslmed.aaa9364

Groop, 1993, Insulin resistance, hypertension and microalbuminuria in patients with type 2 (non-insulin-dependent) diabetes mellitus, Diabetologia, 36, 642, 10.1007/BF00404074

Gnudi, 2016, Diabetic nephropathy: perspective on novel molecular mechanisms, Trends Endocrinol Metab, 27, 820, 10.1016/j.tem.2016.07.002

Welsh, 2010, Insulin signaling to the glomerular podocyte is critical for normal kidney function, Cell Metab, 12, 329, 10.1016/j.cmet.2010.08.015

Lee, 2011, Estimating missing heritability for disease from genome-wide association studies, Am J Hum Genet, 88, 294, 10.1016/j.ajhg.2011.02.002

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Lancet Diabetes and Endocrinology,The

Tập 6 Số 5

361-369

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