Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

Journal of Medicinal Chemistry - Tập 53 Số 13 - Trang 4927-4937 - 2010
María Isabel Fernández‐Bachiller1, Concepción Pérez1, Gema C. González-Muñoz1, Santiago Conde1, Manuela G. López2,3, Mércedes Villarroya2,3, Antonio G. Garcı́a2,3,4, María Isabel Rodríguez‐Franco1
1Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain
2Departamento de Farmacología y Terapéutica, Facultad de Medicina
3Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Arzobispo Morcillo 4, 28029 Madrid, Spain
4Servicio de Farmacología Clínica, Hospital Universitario de la Princesa, Diego de León 62, 28006 Madrid, Spain

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