Nonsteroidal antiinflammatory drugs (NSAIDs) and articular cartilage integrity

Barrett, 1978, The possible role of neutrophil proteinases in damage to articular cartilage, Agents Actions, 8, 11, 10.1007/BF01972396 Janoff, 1976, Degradation of cartilage proteoglycans by human leukocyte granule neutral proteases—A model of joint injury. II. Degradation of isolated bovine nasal cartilage, J Clin Invest, 57, 615, 10.1172/JCI108317 Werb, 1975, Elastase secretion by stimulated macrophages, characterization and regulation, J Exp Med, 142, 361, 10.1084/jem.142.2.361 Deshmukh-Phadke, 1978, Synthesis of collagenase and neutral proteases by articular cartilage chondrocytes: Stimulation by a macrophage-derived factor, Biochem Biophys Res Commun, 85, 490, 10.1016/S0006-291X(78)80068-0 Sapolsky, 1976, Metallo proteases of human articular cartilage that digest cartilage proteoglycans at neutral and acid pH, J Clin Invest, 58, 1030, 10.1172/JCI108526 McKenzie, 1976, The effects of antiinflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage, Ann Rheum Dis, 35, 487, 10.1136/ard.35.6.487 Schmidt, 1974, Isolation of elastase-like and chymotrypsin-like neutral protease from human granulocytes, Hoppe Seylers Z Physiol Chem, 355, 1077, 10.1515/bchm2.1974.355.2.1077 Unkeless, 1973, An enzymatic function associated with transformation of fibroblasts by oncogenic viruses, J Exp Med, 137, 85, 10.1084/jem.137.1.85 Stephens, 1978, Radioassay for proteolytic cleavage of isolated cartilage proteoglycan: I. Separation principles and variables, Anal Biochem, 90, 726, 10.1016/0003-2697(78)90164-1 Walton, 1981, The role of serine protease inhibitors in normal and osteoarthrotic human articular cartilage Kruze, 1976, Effect of anti-rheumatic drugs on neutral proteases from human leukocyte granules, Z Rheumatol, 35, 337 Verbruggen, 1977, Influence of sulphated glycosaminoglycans upon proteoglycan metabolism of the synovial lining cells, Acta Rhumatologua Belg, 1, 75