Nimotuzumab and radiotherapy for treatment of newly diagnosed diffuse intrinsic pontine glioma (DIPG): a phase III clinical study

Gudrun Fleischhack1,2, Maura Massimino3, Monika Warmuth‐Metz4, E. Khuhlaeva5, G Janßen6, Norbert Graf7, Stefan Rutkowski8,9, Andreas Beilken10, Irene Schmid11, Veronica Biassoni3, Sergey Gorelishev5, Christof M. Kramm12,6, Harald Reinhard7,13, Paul‐Gerhardt Schlegel9, Rolf‐Dieter Kortmann14, Dirk Reuter15, F. Bach15, Normando Iznaga-Escobar16, Udo Bode1
1Department of Paediatric Haematology/Oncology, Children Medical Hospital, University of Bonn, Bonn, Germany
2Paediatric Haematology and Oncology, Paediatrics III, University Hospital of Essen, Essen, Germany
3Paediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
4Department of Neuroradiology, University of Wuerzburg, Würzburg, Germany
5Paediatric Neurosurgical Department, Burdenko Neurosurgical Institute, Moscow, Russia
6Department of Paediatric Haematology/Oncology, Children’s Medical Hospital, University of Duesseldorf, Düsseldorf, Germany
7Department of Paediatric Haematology/Oncology, Saarland University, Homburg/Saar, Germany
8Department of Paediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
9Department of Paediatric Hematology/Oncology, University of Wuerzburg, University Children’s Hospital, Wuerzburg, Germany
10Department of Paediatric Haematology/Oncology, Medical School, Children’s Medical Hospital, Hannover, Germany
11Department of Paediatric Haematology/Oncology, Children’s Medical Hospital, University of Munich, Munich, Germany
12Division of Paediatric Haematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, Göttingen, Germany
13Paediatric Haematology and Oncology, Asklepios Hospital, Sankt Augustin, Germany
14Department of RT and Radiooncology, University of Leipzig, Leipzig, Germany
15Oncoscience GmbH, Schenefeld, Germany
16Center of Molecular Immunology, Havana, Cuba

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