New Insights into Biliverdin Reductase Functions: Linking Heme Metabolism to Cell Signaling

Physiology - Tập 20 Số 6 - Trang 382-389 - 2005
Mahin D. Maines1
1Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York

Tóm tắt

Biliverdin reductase (BVR) functions in cell signaling through three distinct tracks: a dual-specificity kinase that functions in the insulin receptor/MAPK pathways ( 25 , 29 , 51 ); a bzip-type transcription factor for ATF-2/CREB and HO-1 regulation ( 1 , 25 ); and a reductase that catalyzes the conversion of biliverdin to bilirubin ( 27 ). These, together with the protein’s primary and secondary features, intimately link BVR to the entire spectrum of cell-signaling cascades.

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