Neuroprotective Effect of Kaempferol Glycosides against Brain Injury and Neuroinflammation by Inhibiting the Activation of NF-κB and STAT3 in Transient Focal Stroke

CA Molina, 2009, Recanalization and reperfusion therapies for acute ischemic stroke, Cerebrovasc Dis, 27, S162, 10.1159/000200455

A Durukan, 2007, Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia, Pharmacol Biochem Behav, 87, 179, 10.1016/j.pbb.2007.04.015

SE Lakhan, 2009, Inflammatory mechanisms in ischemic stroke: therapeutic approaches, J Transl Med, 7, 97, 10.1186/1479-5876-7-97

KW Muir, 2007, Inflammation and ischaemic stroke, Curr Opin Neurol, 20, 334, 10.1097/WCO.0b013e32813ba151

JH Yi, 2007, Role of transcription factors in mediating post-ischemic cerebral inflammation and brain damage, Neurochem Int, 50, 1014, 10.1016/j.neuint.2007.04.019

GJ del Zoppo, 2010, The neurovascular unit in the setting of stroke, J Intern Med, 267, 156, 10.1111/j.1365-2796.2009.02199.x

GJ del Zoppo, 1991, Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons, Stroke, 22, 1276, 10.1161/01.STR.22.10.1276

GF Hamann, 1996, Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia / reperfusion, J Cereb Blood Flow Metab, 16, 1373, 10.1097/00004647-199611000-00036

F Shi, 2006, The chemical components and the pharmacological studies progress of Carthamus, Li Shi Zhen Med Materia Medica Res, 17, 1666

E Middleton Jr, 2000, The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer, Pharmacol Rev, 52, 673

JL Huang, 2007, Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats, Pharmacol Biochem Behav, 86, 741, 10.1016/j.pbb.2007.03.003

R Li, 2006, Nicotiflorin reduces cerebral ischemic damage and upregulates endothelial nitric oxide synthase in primarily cultured rat cerebral blood vessel endothelial cells, J Ethnopharmacol, 107, 143, 10.1016/j.jep.2006.04.024

Z Parveen, 2007, Anti- inflammatory and analgesic activities of Thesium chinense Turcz extracts and its major flavonoids, kaempferol and kaempferol-3-O-glucoside, Yakugaku Zasshi, 127, 1275, 10.1248/yakushi.127.1275

G Autore, 2001, Inhibition of nitric oxide synthase expression by a methanolic extract of Crescentia alata and its derived flavonols, Life Sci, 70, 523, 10.1016/S0024-3205(01)01425-4

H Oh, 2004, Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense, J Ethnopharmacol, 95, 421, 10.1016/j.jep.2004.08.015

D Yu, 2010, Determination of total flavonoids and kaempferol-3-O-rutinoside in Safflower produced in Sichuan and Safflower variety named white flower, West China J Pharmaceu Sci, 25, 751

EZ Longa, 1989, Reversible middle cerebral artery occlusion without craniectomy in rats, Stroke, 20, 84, 10.1161/01.STR.20.1.84

HY Peng, 2007, Neuroprotective effect of Z-ligustilide against permanent focal ischemic damage in rats, Biol Pharm Bull, 30, 309, 10.1248/bpb.30.309

Y Chen, 2012, Neuroprotection of tanshinone IIA against cerebral ischemia/reperfusion injury through inhibition of macrophage migration inhibitory factor in rats, PLoS One, 7, e40165, 10.1371/journal.pone.0040165

X Kuang, 2009, Protective effect of Z-ligustilide against amyloid beta-induced neurotoxicity is associated with decreased pro- inflammatory markers in rat brains, Pharmacol Biochem Behav, 92, 635, 10.1016/j.pbb.2009.03.007

K Chu, 2006, Peroxisome proliferator- -activated receptor-gamma-agonist, rosiglitazone, promotes angiogenesis after focal cerebral ischemia, Brain Res, 1093, 208, 10.1016/j.brainres.2006.03.114

SE Park, 2011, Kaempferol acts through mitogen- activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells, Br J Pharmacol, 164, 1008, 10.1111/j.1476-5381.2011.01389.x

F Liu, 2009, TTC, Fluoro-Jade B and NeuN staining confirm evolving phases of infarction, J Neurosci Methods, 179, 1, 10.1016/j.jneumeth.2008.12.028

IM Medana, 2003, Axonal damage: a key predictor of outcome in human CNS diseases, Brain, 126, 515, 10.1093/brain/awg061

MM Gresle, 2006, Injury to axons and oligodendrocytes following endothelin-1-induced middle cerebral artery occlusion in conscious rats, Brain Res, 110, 13, 10.1016/j.brainres.2006.06.111

D Dewar, 1995, Tau protein is altered by focal cerebral ischaemia in the rat: an immunohistochemical and immunoblotting study, Brain Res, 684, 70, 10.1016/0006-8993(95)00417-O

M Schilling, 2003, Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice, Exp Neurol, 183, 25, 10.1016/S0014-4886(03)00082-7

RA Swanson, 2004, Astrocyte influences on ischemic neuronal death, Curr Mol Med, 4, 193, 10.2174/1566524043479185

J Bromberg, 2000, The role of STATs in transcriptional control and their impact on cellular function, Oncogene, 19, 2468, 10.1038/sj.onc.1203476

I Satriotomo, 2006, JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia, J Neurochem, 98, 1353, 10.1111/j.1471-4159.2006.04051.x

S Suzuki, 2001, Phosphorylation of signal transducer and activator of transcription-3(STAT3) after focal cerebral ischemia in rats, Exp Neurol, 170, 63, 10.1006/exnr.2001.7701

CY Sasaki, 2005, Phosphorylation of RelA/p65 on serine 536 defines an IκBα-independent NF-κB pathway, J Biol Chem, 280, 34538, 10.1074/jbc.M504943200

A Kunz, 2008, Nuclear factor κB activation and postischemic inflammation are suppressed in CD36- null mice after middle cerebral artery occlusion, J Neurosci, 28, 1649, 10.1523/JNEUROSCI.5205-07.2008

2002, The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct?, Exp Neurol, 173, 168, 10.1006/exnr.2001.7835

K Tsuji, 2005, Tissue plasminogen activator promotes matrix metallop- roteinase-9 up regulation after focal cerebral ischemia, Stroke, 36, 1954, 10.1161/01.STR.0000177517.01203.eb

RM Weston, 2007, Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: Histochemical and myeloperoxidase correlation with temporal changes in brain injury, J Cereb Blood Flow Metab, 27, 100, 10.1038/sj.jcbfm.9600324