Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease

Alam, 1997, Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra, J. Neurochem, 69, 1196, 10.1046/j.1471-4159.1997.69031196.x

Andres-Lacueva, 2005, Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory, Nutr. Neurosci, 8, 111, 10.1080/10284150500078117

Bandyopadhyay, 2007, Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein, Exp. Gerentol, 42, 120, 10.1016/j.exger.2006.05.019

Betarbet, 2000, Chronic systemic pesticide exposure reproduces features of Parkinson's disease, Nat. Neurosci, 3, 1301, 10.1038/81834

Betarbet, 2005, Ubiquitin-proteasome system and Parkinson's diseases, Exp. Neurol, 191, S17, 10.1016/j.expneurol.2004.08.021

Bharat, 2002, Glutathione, iron and Parkinson's disease, Biochem. Pharmacol, 64, 1037, 10.1016/S0006-2952(02)01174-7

Boland, 2006, Neuronal macroautophagy: Form development to degeneration, Mol. Aspects Med, 27, 503, 10.1016/j.mam.2006.08.009

Butler, 2006, Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases, Autophagy, 2, 234, 10.4161/auto.2729

Calabresi, 2000, Electrophysiology of dopamine in normal and denervated striatal neurons, Trends Neurosci., 23, 57, 10.1016/S1471-1931(00)00017-3

Centonze, 2006, Deficits of glutamate transmission in the striatum of experimental hemiballism, Neuroscience, 143, 213, 10.1016/j.neuroscience.2006.07.024

Chen, 2009, Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases, Hum. Mol. Genet, 18, R169, 10.1093/hmg/ddp326

Chu, 2009, Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions, Neurobiol. Dis, 35, 385, 10.1016/j.nbd.2009.05.023

Datla, 2007, Short-term supplementation with plant extracts rich in flavonoids protect nigrostriatal dopaminergic neurons in rat model of Parkinson's disease, J. Am. Coll. Nutr, 26, 314, 10.1080/07315724.2007.10719621

Desagher, 2000, Mitochondria as the central control point of apoptosis, Trends Cell Biol., 10, 369, 10.1016/S0962-8924(00)01803-1

Dexter, 1989, Basal lipid peroxidation in substatia nigra is increased in Parkinson's disease, J. Neurochem, 52, 381, 10.1111/j.1471-4159.1989.tb09133.x

Dodson, 2007, PINK1, Parkin, DJ-one and mitochondrial dysfunction in Parkinson's disease, Curr. Opin. Neurobiol, 17, 331, 10.1016/j.conb.2007.04.010

Drechsel, 2009, Differential contribution of the mitochondrial respiratory chain complexes to reactive oxygen species production by redox cycling agents implicated in parkinsonism, Toxicol. Sci, 112, 427, 10.1093/toxsci/kfp223

Filomeni, 2003, Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide, Cancer Res., 63, 5940

Filomeni, 2007, Pro-apoptotic activity of novel Isatin-Schiff base copper(II) complexes depends on oxidative stress induction and organelle-selective damage, J. Biol. Chem, 282, 12010, 10.1074/jbc.M610927200

Filomeni, 2010, Carcinoma cells activate AMP-activated protein kinase-dependent autophagy as survival response to kaempferol-mediated energetic impairment, Autophagy, 6, 202, 10.4161/auto.6.2.10971

Floor, 1998, Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay, J. Neurochem, 70, 268, 10.1046/j.1471-4159.1998.70010268.x

Fornai, 2005, Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein, Proc. Natl. Acad. Sci. U. S. A., 102, 3413, 10.1073/pnas.0409713102

Gomes, 2008, High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy, Biochim. Biophys. Acta, 1777, 860, 10.1016/j.bbabio.2008.05.442

González-Polo, 2007, Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells, Toxicol. Sci., 97, 448, 10.1093/toxsci/kfm040

Hara, 2006, Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice, Nature, 441, 885, 10.1038/nature04724

Huang, 2004, Redox-active metals, oxidative stress, and Alzheimer's disease pathology, Ann. N. Y. Acad. Sci, 1012, 153, 10.1196/annals.1306.012

Jiang, 2006, Neurotrophic factors stabilize microtubules and protects from rotenone toxicity on dopaminergic neurons, J. Biol. Chem, 281, 29391, 10.1074/jbc.M602740200

Joseph, 2009, Nutrition, Brain Aging, and Neurodegeneration, J. Neurosci, 29, 12795, 10.1523/JNEUROSCI.3520-09.2009

Kanzawa, 2004, Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells, Cell Death Differ., 11, 448, 10.1038/sj.cdd.4401359

Kroemer, 2005, Lysosomes and autophagy in cell death control, Nat. Rev. Cancer, 5, 886, 10.1038/nrc1738

Lagoa, 2009, Kaempferol protects against rat striatal degeneration induced by 3-nitropropionic acid, J. Neurochem, 111, 473, 10.1111/j.1471-4159.2009.06331.x

Loeb, 2010, The transgenic over expression of α-Synuclein and not its related pathology, associates with complex I inhibition, J. Biol. Chem, 285, 7334, 10.1074/jbc.M109.061051

Lopez-Sanchez, 2007, Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain, Biochem. Pharmacol, 1182, 123

Lowry, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem, 193, 265, 10.1016/S0021-9258(19)52451-6

Malagelada, 2010, Rapamycin protects against neuron death in in vitro and in in vivo models of Parkinson's disease, J. Neurosci, 30, 1166, 10.1523/JNEUROSCI.3944-09.2010

Mandel, 2006, Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders, Mol. Nutr. Food Res, 50, 229, 10.1002/mnfr.200500156

Martinez-Vicente, 2007, Autophagy and neurodegeneration: when the cleaning crew goes on strike, Lancet Neurol, 6, 352, 10.1016/S1474-4422(07)70076-5

Mizushima, 2007, How to interpret LC3 immunoblotting, Autophagy, 3, 542, 10.4161/auto.4600

Moldzio, 2008, Rotenone damages striatal organotypic slice culture, Ann. N Y Acad. Sci, 1148, 530, 10.1196/annals.1410.009

Narendra, 2008, Parkin is recruited selectively to impaired mitochondria and promotes their autophagy, J. Cell Biol, 183, 795, 10.1083/jcb.200809125

Nedelsky, 2008, Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection, Biochim. Biophys. Acta, 1782, 691, 10.1016/j.bbadis.2008.10.002

Nicoletti, 1991, A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry, J. Immunol. Methods, 139, 271, 10.1016/0022-1759(91)90198-O

Okun, 1999, Three classes of inhibitors share a common binding domain in mitochondrial complex, J. Biol. Chem, 274, 2625, 10.1074/jbc.274.5.2625

Pan, 2008, The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease, Brain, 131, 1969, 10.1093/brain/awm318

Pan, 2009, Rapamycin protects against rotenone-induced apoptosis through autophagy induction, Neuroscience, 164, 541, 10.1016/j.neuroscience.2009.08.014

Paul, 2008, Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: therapeutic approaches, Bioessays, 30, 1172, 10.1002/bies.20852

Park, 2009, The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodelling process, Biochem. Biophys. Res. Commun, 378, 518, 10.1016/j.bbrc.2008.11.086

Poole, 2008, The PINK1/Parkin pathway regulates mitochondrial morphology, Proc. Natl. Acad. Sci. U. S. A., 105, 1638, 10.1073/pnas.0709336105

Richardson, 2007, Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), Toxicol. Sci, 95, 196, 10.1093/toxsci/kfl133

Rossi, 2008, Benefits from dietary polyphenols for brain aging and Alzheimer's disease, Neurochem. Res, 33, 2390, 10.1007/s11064-008-9696-7

Rubinsztein, 2007, Potential therapeutic applications of autophagy, Nat. Rev. Drug Discov., 6, 304, 10.1038/nrd2272

Sarkar, 2009, Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies, Cell Death Differ., 16, 46, 10.1038/cdd.2008.110

Sherer, 2007, Mechanism of toxicity of pesticides acting at complex, J. Neurochem, 100, 1469, 10.1111/j.1471-4159.2006.04333.x

Srivastava, 2007, Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding, FEBS J., 274, 4788, 10.1111/j.1742-4658.2007.06004.x

Sulzer, 2000, Intraneuronal dopamine-quinone synthesis: a review, Neurotox. Res, 1, 181, 10.1007/BF03033289

Testa, 2005, Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures, Brain Res. Mol. Brain Res, 134, 109, 10.1016/j.molbrainres.2004.11.007

Tolkovsky, 2009, Mitophagy, Biochim. Biophys. Acta, 1793, 1508, 10.1016/j.bbamcr.2009.03.002

Vives-Bauza, 2010, PINK1-dependent recruitment of Parkin to mitochondria in mitophagy, Proc. Natl. Acad. Sci. U. S. A., 107, 378, 10.1073/pnas.0911187107

Williams, 2006, Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications, Curr. Top. Dev. Biol., 76, 89, 10.1016/S0070-2153(06)76003-3

Willis, 2009, Recent advances in berry supplementation and age-related cognitive decline, Curr. Opin. Clin. Nutr. Metab. Care, 12, 91, 10.1097/MCO.0b013e32831b9c6e

Yang, 2009, Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Hungtington diseases, J. Neurochem, 109, 1427, 10.1111/j.1471-4159.2009.06074.x

Zeng, 2008, Mammalian target of rapamycin and S6 kinase one positively regulate 6-thioguanine-induced autophagy, Cancer Res., 68, 2384, 10.1158/0008-5472.CAN-07-6163

Zhang, 2005, Mitochondrial localization of the Parkinson's disease related protein DJ-one: implications for pathogenesis, Hum. Mol. Genet, 14, 2063, 10.1093/hmg/ddi211

Zhang, 2002, Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk, Neurology, 59, 1161, 10.1212/01.WNL.0000028688.75881.12

Zhao, 2009, Natural antioxidants protect neurons in Alzheimer's and Parkinson's disease, Neurochem. Res, 34, 630, 10.1007/s11064-008-9900-9