Neuropeptides, food intake and body weight regulation: a hypothalamic focus
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Adage, 2001, Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats, J. Neurosci., 21, 3639, 10.1523/JNEUROSCI.21-10-03639.2001
Adan, 2000, Melanocortins and the brain: from effects via receptors to drug targets, Eur. J. Pharmacol., 405, 13, 10.1016/S0014-2999(00)00537-9
Adelman G, Smith BH, editors. Elsevier’s enceclopedia of neuroscience. Amsterdam: Elsevier; 1989.
Ahima, 1996, Role of leptin in the neuroendocrine response to fasting, Nature, 382, 250, 10.1038/382250a0
Allen, 1983, Neuropeptide Y distribution in the rat brain, Science, 221, 877, 10.1126/science.6136091
Ammar, 2000, NPY-leptin: opposing effects on appetitive and consummatory ingestive behavior and sexual behavior, Am. J. Physiol. Regul. Integr. Comp. Physiol, 278, R1627, 10.1152/ajpregu.2000.278.6.R1627
An, 2001, Identification and characterization of a melanin-concentrating hormone receptor, Proc. Natl. Acad. Sci. U.S.A., 98, 7576, 10.1073/pnas.131200698
Arima, 2000, Vasopressin and oxytocin neurones of hypothalamic supraoptic and paraventricular nuclei co-express mRNA for Type-1 and Type-2 corticotropin-releasing hormone receptors, J. Neuroendocrinol., 12, 833, 10.1046/j.1365-2826.2000.00528.x
Arletti, 1989, Influence of oxytocin on feeding behavior in the rat, Peptides, 10, 89, 10.1016/0196-9781(89)90082-X
Arnelo, 1996, Chronic infusion of islet amyloid polypeptide causes anorexia in rats, Am. J. Physiol., 271, R1654
Baile, 1986, Role of cholecystokinin and opioid peptides in control of food intake, Physiol. Rev., 66, 172, 10.1152/physrev.1986.66.1.172
Bale, 2000, Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress, Nat. Genet., 24, 410, 10.1038/74263
Bannon, 2000, Behavioral characterization of neuropeptide Y knockout mice, Brain Res., 868, 79, 10.1016/S0006-8993(00)02285-X
Bannon, 2000, Biological functions of cocaine- and amphetamine-regulated transcript (CART): data with CART peptides and CART knockout mice, Soc. Neurosci. Abstr., 26, 2041 (761.10)
Baskin, 1999, Leptin binding in the arcuate nucleus is increased during fasting, Brain Res., 828, 154, 10.1016/S0006-8993(99)01252-4
Baskin, 1988, Insulin and insulin-like growth factors in the CNS, Trends Neurosci., 11, 107, 10.1016/0166-2236(88)90155-5
Bataille, 1982, Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Characterization of the peptide, FEBS Lett., 146, 79, 10.1016/0014-5793(82)80709-6
Beck, 1989, Neurotensin in microdissected brain nuclei and in the pituitary of the lean and obese Zucker rats, Neuropeptides, 13, 1, 10.1016/0143-4179(89)90014-0
Bertolini, 1969, Induction of sexual excitement by the action of adrenocorticotrophic hormone in brain, Nature, 221, 667, 10.1038/221667a0
Billington, 1991, Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism, Am. J. Physiol., 260, R321
Bissette, 1976, Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin, Nature, 262, 607, 10.1038/262607a0
Bittencourt, 1992, The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization-histochemical characterization, J. Comp. Neurol., 319, 218, 10.1002/cne.903190204
Bjorbaek, 1998, Identification of SOCS-3 as a potential mediator of central leptin resistance, Mol. Cell, 1, 619, 10.1016/S1097-2765(00)80062-3
Blakeman, 2001, Mice over-expressing galanin have elevated heat nociceptive threshold, Neuroreport, 12, 423, 10.1097/00001756-200102120-00046
Bradbury, 2000, Modulation of urocortin-induced hypophagia and weight loss by corticotropin-releasing factor receptor 1 deficiency in mice [see comments], Endocrinology, 141, 2715, 10.1210/en.141.8.2715
Bruhn, 1986, Central administration of corticotropin-releasing factor modulates oxytocin secretion in the rat, Endocrinology, 119, 1558, 10.1210/endo-119-4-1558
Bruning, 2000, Role of brain insulin receptor in control of body weight and reproduction, Science, 289, 2122, 10.1126/science.289.5487.2122
Bultman, 1992, Molecular characterization of the mouse agouti locus, Cell, 71, 1195, 10.1016/S0092-8674(05)80067-4
Burcelin, 2001, Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice, Peptides, 22, 421, 10.1016/S0196-9781(01)00357-6
Burgevin, 1995, Cloning, pharmacological characterization, and anatomical distribution of a rat cDNA encoding for a galanin receptor, J. Mol. Neurosci., 6, 33, 10.1007/BF02736757
Butler, 2000, A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse, Endocrinology, 141, 3518, 10.1210/en.141.9.3518
Butler, 1990, Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans, Diabetes, 39, 752, 10.2337/diabetes.39.6.752
Cabeza, 2002, The melanocortin receptor agonist MTII augments the rewarding effect of amphetamine in ad-libitum-fed and food-restricted rats, Psychopharmacology (Berl.), 161, 77, 10.1007/s00213-002-0998-1
Calza, 2000, Expression of peptides and other neurochemical markers in hypothalamus and olfactory bulb of mice devoid of all known thyroid hormone receptors, Neuroscience, 101, 1001, 10.1016/S0306-4522(00)00420-6
Carvalheira, 2001, Insulin modulates leptin–induced STAT3 activation in rat hypothalamus, FEBS Lett., 500, 119, 10.1016/S0014-5793(01)02591-1
Chalmers, 1995, Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression, J. Neurosci., 15, 6340, 10.1523/JNEUROSCI.15-10-06340.1995
Chapman, 1998, Effect of intravenous glucose and euglycemic insulin infusions on short-term appetite and food intake, Am. J. Physiol., 274, R596
Chen, 1996, Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice, Cell, 84, 491, 10.1016/S0092-8674(00)81294-5
Cheung, 2001, Distribution of galanin messenger RNA-expressing cells in murine brain and their regulation by leptin in regions of the hypothalamus, Neuroscience, 103, 423, 10.1016/S0306-4522(01)00012-4
Clineschmidt, 1979, Neurotensin: antinocisponsive action in rodents, Eur. J. Pharmacol., 54, 129, 10.1016/0014-2999(79)90415-1
Corp, 1990, Effect of fourth ventricular neuropeptide Y and peptide YY on ingestive and other behaviors, Am. J. Physiol., 259, R317
Cortright, 1997, Isolation and characterization of the rat corticotropin-releasing hormone (CRH)-binding protein gene: transcriptional regulation by cyclic adenosine monophosphate and CRH, Endocrinology, 138, 2098, 10.1210/en.138.5.2098
Corwin, 1992, Decreased behavioral effects of daily intracerebroventricular bombesin, Peptides, 13, 1215, 10.1016/0196-9781(92)90031-W
Cowley, 2001, Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus, Nature, 411, 480, 10.1038/35078085
Cusin, 1998, Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins, Diabetes, 47, 1014, 10.2337/diabetes.47.7.1014
D’Alessio, 1994, Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse, Diabetes, 43, 1457, 10.2337/diabetes.43.12.1457
Date, 2000, Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans, Endocrinology, 141, 4255, 10.1210/en.141.11.4255
Date, 1999, Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems, Proc. Natl. Acad. Sci. U.S.A., 96, 748, 10.1073/pnas.96.2.748
De Wied, 1974, Neuropeptides and behavior, Ned. Tijdschr. Geneeskd., 118, 1865
Deacon, 1995, Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo, J. Clin. Endocrinol. Metab., 80, 952, 10.1210/jc.80.3.952
DeFalco, 2001, Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus, Science, 291, 2608, 10.1126/science.1056602
Denbow, 1989, Centrally and peripherally administered bombesin decreases food intake in turkeys, Peptides, 10, 275, 10.1016/0196-9781(89)90030-2
Desarnaud, 1994, Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene, Biochem. J., 299, 367, 10.1042/bj2990367
Dobner, 2001, Neurotensin-deficient mice show altered responses to antipsychotic drugs, Proc. Natl. Acad. Sci. U.S.A., 98, 8048, 10.1073/pnas.141042198
Douglass, 1995, PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine, J. Neurosci., 15, 2471, 10.1523/JNEUROSCI.15-03-02471.1995
Dourish, 1989, Postponement of satiety by blockade of brain cholecystokinin (CCK-B) receptors, Science, 245, 1509, 10.1126/science.2781294
Drucker, 2002, Biological actions and therapeutic potential of the glucagon-like peptides, Gastroenterology, 122, 531, 10.1053/gast.2002.31068
Drucker, 1988, Glucagon gene expression in vertebrate brain, J. Biol. Chem., 263, 13475, 10.1016/S0021-9258(18)68261-4
Drucker, 1996, Induction of intestinal epithelial proliferation by glucagon-like peptide 2, Proc. Natl. Acad. Sci. U.S.A., 93, 7911, 10.1073/pnas.93.15.7911
Edwards, 2000, Cocaine- and amphetamine-regulated transcript, glucagon-like peptide-1 and corticotrophin releasing factor inhibit feeding via agouti-related protein independent pathways in the rat, Brain Res., 866, 128, 10.1016/S0006-8993(00)02257-5
Edwards, 1999, The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin, J. Endocrinol., 160, R7, 10.1677/joe.0.160R007
Elias, 1999, Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area, Neuron, 23, 775, 10.1016/S0896-6273(01)80035-0
Elias, 1998, Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area, J. Comp. Neurol., 402, 442, 10.1002/(SICI)1096-9861(19981228)402:4<442::AID-CNE2>3.0.CO;2-R
Elmquist, 1998, Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei, Proc. Natl. Acad. Sci. U.S.A., 95, 741, 10.1073/pnas.95.2.741
Elmquist, 1998, Distributions of leptin receptor mRNA isoforms in the rat brain, J. Comp. Neurol., 395, 535, 10.1002/(SICI)1096-9861(19980615)395:4<535::AID-CNE9>3.0.CO;2-2
Elmquist, 1999, From lesions to leptin: hypothalamic control of food intake and body weight, Neuron, 22, 221, 10.1016/S0896-6273(00)81084-3
Emond, 1999, Central leptin modulates behavioral and neural responsivity to CCK, Am. J. Physiol., 276, R1545
Erickson, 1996, Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y, Nature, 381, 415, 10.1038/381415a0
Fan, 2000, The central melanocortin system can directly regulate serum insulin levels, Endocrinology, 141, 3072, 10.1210/en.141.9.3072
Fathi, 1993, BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells, J. Biol. Chem., 268, 5979, 10.1016/S0021-9258(18)53415-3
Flood, 1989, Dissociation of the effects of neuropeptide Y on feeding and memory: evidence for pre- and postsynaptic mediation, Peptides, 10, 963, 10.1016/0196-9781(89)90176-9
Flynn, 1991, Effects of fourth ventricle bombesin injection on meal-related parameters and grooming behavior, Peptides, 12, 761, 10.1016/0196-9781(91)90130-H
Flynn, 1992, Inhibition of ingestive behavior following fourth ventricle bombesin injection in chronic decerebrate rats, Behav. Neurosci., 106, 1011, 10.1037/0735-7044.106.6.1011
Forbes, 2001, Integrated control of appetite and fat metabolism by the leptin–proopiomelanocortin pathway, Proc. Natl. Acad. Sci. U.S.A., 98, 4233, 10.1073/pnas.071054298
Forrest, 1996, Thyroid hormone receptor beta is essential for development of auditory function, Nat. Genet., 13, 354, 10.1038/ng0796-354
Friedman, 1998, Leptin and the regulation of body weight in mammals, Nature, 395, 763, 10.1038/27376
Furuse, 1997, Influence of fasting and neuropeptide Y on the suppressive food intake induced by intracerebroventricular injection of glucagon-like peptide-1 in the neonatal chick, Brain Res., 764, 289, 10.1016/S0006-8993(97)00623-9
Gantz, 1993, Molecular cloning, expression, and gene localization of a fourth melanocortin receptor, J. Biol. Chem., 268, 15174, 10.1016/S0021-9258(18)82452-8
Gantz, 1994, Molecular cloning, expression, and characterization of a fifth melanocortin receptor, Biochem. Biophys. Res. Commun., 200, 1214, 10.1006/bbrc.1994.1580
Gautvik, 1996, Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction, Proc. Natl. Acad. Sci. U.S.A., 93, 8733, 10.1073/pnas.93.16.8733
Gebre-Medhin, 1998, Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin), Biochem. Biophys. Res. Commun., 250, 271, 10.1006/bbrc.1998.9308
Ghilardi, 1996, Defective STAT signaling by the leptin receptor in diabetic mice, Proc. Natl. Acad. Sci. U.S.A., 93, 6231, 10.1073/pnas.93.13.6231
Gibbs, 1976, Cholecystokinin-decreased food intake in rhesus monkeys, Am. J. Physiol., 230, 15, 10.1152/ajplegacy.1976.230.1.15
Gibbs, 1973, Cholecystokinin decreases food intake in rats, J. Comp. Physiol. Psychol., 84, 488, 10.1037/h0034870
Goldstone, 2000, Effect of leptin on hypothalamic GLP-1 peptide and brain-stem pre-proglucagon mRNA, Biochem. Biophys. Res. Commun., 269, 331, 10.1006/bbrc.2000.2288
Graham, 1997, Overexpression of Agrt leads to obesity in transgenic mice, Nat. Genet., 17, 273, 10.1038/ng1197-273
Gray, 1993, Amygdaloid CRF pathways. Role in autonomic, neuroendocrine, and behavioral responses to stress, Ann. N.Y. Acad. Sci., 697, 53, 10.1111/j.1749-6632.1993.tb49922.x
Gray, 1987, Neuropeptide neuronal efferents from the bed nucleus of the stria terminalis and central amygdaloid nucleus to the dorsal vagal complex in the rat, J. Comp. Neurol., 262, 365, 10.1002/cne.902620304
Griffon, 1994, Molecular cloning and characterization of the rat fifth melanocortin receptor, Biochem. Biophys. Res. Commun., 200, 1007, 10.1006/bbrc.1994.1550
Grill, 2002, Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake, Endocrinology, 143, 239, 10.1210/en.143.1.239
Hagan, 1999, Orexin A activates locus coeruleus cell firing and increases arousal in the rat, Proc. Natl. Acad. Sci. U.S.A., 96, 10911, 10.1073/pnas.96.19.10911
Hagan, 2002, Peptide YY: a key mediator of orexigenic behavior, Peptides, 23, 377, 10.1016/S0196-9781(01)00614-3
Hagan, 2001, Opioid receptor involvement in the effect of AgRP-(83–132) on food intake and food selection, Am. J. Physiol Regul. Integr. Comp. Physiol., 280, R814, 10.1152/ajpregu.2001.280.3.R814
Hagan, 2000, Long-term orexigenic effects of AgRP-(83–132) involve mechanisms other than melanocortin receptor blockade, Am. J. Physiol. Regul. Integr. Comp. Physiol., 279, R47, 10.1152/ajpregu.2000.279.1.R47
Hagan, 1999, Role of the CNS melanocortin system in the response to overfeeding, J. Neurosci., 19, 2362, 10.1523/JNEUROSCI.19-06-02362.1999
Hahn, 1998, Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons, Nat. Neurosci., 1, 271, 10.1038/1082
Hampton, 1998, Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice, Proc. Natl. Acad. Sci. U.S.A., 95, 3188, 10.1073/pnas.95.6.3188
Han, 1986, Cellular localization of proglucagon/glucagon-like peptide I messenger RNAs in rat brain, J. Neurosci. Res., 16, 97, 10.1002/jnr.490160110
Hara, 2001, Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity, Neuron, 30, 345, 10.1016/S0896-6273(01)00293-8
Haynes, 1999, Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat, Peptides, 20, 1099, 10.1016/S0196-9781(99)00105-9
Heinrichs, 1993, Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y, Brain Res., 611, 18, 10.1016/0006-8993(93)91771-J
Hetherington, 1940, Hypothalamic lesions and adiposity in the rat, Anat. Rec., 78, 149, 10.1002/ar.1090780203
Heuer, 2000, Expression of thyrotropin-releasing hormone receptor 2 (TRH-R2) in the central nervous system of rats, J. Comp. Neurol., 428, 319, 10.1002/1096-9861(20001211)428:2<319::AID-CNE10>3.0.CO;2-9
Holdeman, 1985, Antipyretic activity of a potent alpha-MSH analog, Peptides, 6, 273, 10.1016/0196-9781(85)90051-8
Hollopeter, 1998, Response of neuropeptide Y-deficient mice to feeding effectors, Regul. Pept., 75, 383, 10.1016/S0167-0115(98)00092-5
Holmes, 2000, Targeted disruption of the galanin gene reduces the number of sensory neurons and their regenerative capacity, Proc. Natl. Acad. Sci. U.S.A., 97, 11563, 10.1073/pnas.210221897
Horvath, 2001, Minireview: ghrelin and the regulation of energy balance–a hypothalamic perspective, Endocrinology, 142, 4163, 10.1210/en.142.10.4163
Horvath, 1995, Morphological evidence for a galanin–opiate interaction in the rat mediobasal hypothalamus, J. Neuroendocrinol., 7, 579, 10.1111/j.1365-2826.1995.tb00795.x
Horvath, 1996, Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus, Endocrinology, 137, 3069, 10.1210/en.137.7.3069
Howard, 1997, Molecular cloning and characterization of a new receptor for galanin, FEBS Lett., 405, 285, 10.1016/S0014-5793(97)00196-8
Hu, 1996, Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior, J. Biol. Chem., 271, 26315, 10.1074/jbc.271.42.26315
Huang, 1998, Effects of leptin on corticotropin-releasing factor (CRF) synthesis and CRF neuron activation in the paraventricular hypothalamic nucleus of obese (ob/ob) mice, Endocrinology, 139, 1524, 10.1210/en.139.4.1524
Huszar, 1997, Targeted disruption of the melanocortin-4 receptor results in obesity in mice, Cell, 88, 131, 10.1016/S0092-8674(00)81865-6
Iadarola, 1989, Expression of cholecystokinin and enkephalin mRNA in discrete brain regions, Peptides, 10, 687, 10.1016/0196-9781(89)90160-5
Jaszberenyi, 2002, The role of NPY in the mediation of orexin-induced hypothermia, Regul. Pept., 104, 55, 10.1016/S0167-0115(01)00339-1
Jezova, 1992, Rat melanin-concentrating hormone stimulates adrenocorticotropin secretion: evidence for a site of action in brain regions protected by the blood-brain barrier, Endocrinology, 130, 1024, 10.1210/en.130.2.1024
Johnston, 1988, Specific neuroanatomical and neurochemical correlates of locomotor and grooming effects of bombesin, Peptides, 9, 245, 10.1016/0196-9781(88)90250-1
Jonas, 1997, Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion, Nature, 385, 343, 10.1038/385343a0
Jones, 2001, Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity, Psychopharmacology (Berl.), 153, 210, 10.1007/s002130000551
Jureus, 2000, Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat, Endocrinology, 141, 2703, 10.1210/en.141.7.2703
Kaga, 2001, Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding, Diabetes, 50, 1206, 10.2337/diabetes.50.5.1206
Kahn, 1999, Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes, Diabetes, 48, 241, 10.2337/diabetes.48.2.241
Kalra, 1999, Interacting appetite-regulating pathways in the hypothalamic regulation of body weight, Endocr. Rev., 20, 68, 10.1210/er.20.1.68
Kalsbeek, 2001, The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels, Endocrinology, 142, 2677, 10.1210/en.142.6.2677
Kalsbeek, 1993, Efferent projections of the suprachiasmatic nucleus in the golden hamster (Mesocricetus auratus), J. Comp. Neurol., 332, 293, 10.1002/cne.903320304
Kamegai, 2001, Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats, Diabetes, 50, 2438, 10.2337/diabetes.50.11.2438
Kanatani, 2001, A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814, Mol. Pharmacol., 59, 501, 10.1124/mol.59.3.501
Kapeller, 1999, Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin, J. Biol. Chem., 274, 24980, 10.1074/jbc.274.35.24980
Karolyi, 1999, Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice, Proc. Natl. Acad. Sci. U.S.A., 96, 11595, 10.1073/pnas.96.20.11595
Kask, 2000, Differential effects of melanocortin peptides on ingestive behaviour in rats: evidence against the involvement of MC(3) receptor in the regulation of food intake, Neurosci. Lett., 283, 1, 10.1016/S0304-3940(00)00837-5
Kastin, 2000, Activation of urocortin transport into brain by leptin, Peptides, 21, 1811, 10.1016/S0196-9781(00)00349-1
Katsuno, 1999, Pharmacology and cell biology of the bombesin receptor subtype 4 (BB4-R), Biochemistry, 38, 7307, 10.1021/bi990204w
Kerr, 2000, Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury, Eur. J. Neurosci., 12, 793, 10.1046/j.1460-9568.2000.00967.x
Kesterson, 1997, Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome, Mol. Endocrinol., 11, 630, 10.1210/me.11.5.630
Kieffer, 2000, The adipoinsular axis: effects of leptin on pancreatic beta-cells, Am. J. Physiol. Endocrinol. Metab., 278, E1, 10.1152/ajpendo.2000.278.1.E1
Kim, 2000, The central melanocortin system affects the hypothalamo–pituitary–thyroid axis and may mediate the effect of leptin, J. Clin. Invest., 105, 1005, 10.1172/JCI8857
Kimura, 1992, Structure and expression of a human oxytocin receptor, Nature, 356, 526, 10.1038/356526a0
Kishimoto, 2000, Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2, Nat. Genet., 24, 415, 10.1038/74271
Kislauskis, 1988, The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences, J. Biol. Chem., 263, 4963, 10.1016/S0021-9258(18)68881-7
Kojima, 1999, Ghrelin is a growth-hormone-releasing acylated peptide from stomach, Nature, 402, 656, 10.1038/45230
Kolakowski, 1996, Characterization of a human gene related to genes encoding somatostatin receptors, FEBS Lett., 398, 253, 10.1016/S0014-5793(96)01160-X
Koritschoner, 2001, Thyroid hormone regulates the obesity gene tub, EMBO Rep., 2, 499, 10.1093/embo-reports/kve107
Kostich, 1998, Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor, Mol. Endocrinol., 12, 1077, 10.1210/me.12.8.1077
Kotz, 1995, Effects of opioid antagonists naloxone and naltrexone on neuropeptide Y-induced feeding and brown fat thermogenesis in the rat. Neural site of action, J. Clin. Invest., 96, 163, 10.1172/JCI118017
Kristensen, 1998, Hypothalamic CART is a new anorectic peptide regulated by leptin, Nature, 393, 72, 10.1038/29993
Krysiak, 1999, Interactions between the neuropeptide Y system and the hypothalamic–pituitary–adrenal axis, Eur. J. Endocrinol., 140, 130, 10.1530/eje.0.1400130
Kubo, 1995, Cloning of a mouse adrenocorticotropin receptor-encoding gene, Gene, 153, 279, 10.1016/0378-1119(94)00768-N
Kuhar, 1999, CART peptides: novel addiction- and feeding-related neuropeptides, Trends Neurosci., 22, 316, 10.1016/S0166-2236(98)01377-0
Kulkosky, 1976, Satiety elicited by the C-terminal octapeptide of cholecystokinin–pancreozymin in normal and VMH-lesioned rats, Behav. Biol., 18, 227, 10.1016/S0091-6773(76)92134-9
Kunii, 1999, Orexins/hypocretins regulate drinking behaviour, Brain Res., 842, 256, 10.1016/S0006-8993(99)01884-3
Kyrkouli, 1990, Stimulation of feeding by galanin: anatomical localization and behavioral specificity of this peptide’s effects in the brain, Peptides, 11, 995, 10.1016/0196-9781(90)90023-X
Lambert, 1998, CART peptides in the central control of feeding and interactions with neuropeptide Y, Synapse, 29, 293, 10.1002/(SICI)1098-2396(199808)29:4<293::AID-SYN1>3.0.CO;2-0
Larsen, 2000, Chronic intracerebroventricular administration of recombinant CART(42–89) peptide inhibits and causes weight loss in lean and obese Zucker (fa/fa) rats, Obes. Res., 8, 590, 10.1038/oby.2000.76
Laurent, 1989, Expression of the oxytocin and vasopressin genes in the rat hypothalamus during development: an in situ hybridization study, Brain Res. Dev. Brain Res., 46, 145, 10.1016/0165-3806(89)90152-1
Legradi, 1998, The arcuate nucleus is the major source for neuropeptide Y-innervation of thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus, Endocrinology, 139, 3262, 10.1210/en.139.7.3262
Levine, 1983, Effect of centrally administered neurotensin on multiple feeding paradigms, Pharmacol. Biochem. Behav., 18, 19, 10.1016/0091-3057(83)90244-7
Lewis, 2001, Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor, Proc. Natl. Acad. Sci. U.S.A., 98, 7570, 10.1073/pnas.121165198
Li, 2002, Spatial memory deficit and emotional abnormality in OLETF rats, Physiol. Behav., 75, 15, 10.1016/S0031-9384(01)00627-8
Liao, 1991, Anatomical interactions of proopiomelanocortin (POMC)-related peptides, neuropeptide Y (NPY) and dopamine beta-hydroxylase (D beta H) fibers and thyrotropin-releasing hormone (TRH) neurons in the paraventricular nucleus of rat hypothalamus, Neuropeptides, 18, 63, 10.1016/0143-4179(91)90001-Y
Lopez, 2000, Leptin regulation of prepro-orexin and orexin receptor mRNA levels in the hypothalamus, Biochem. Biophys. Res. Commun., 269, 41, 10.1006/bbrc.2000.2245
Lovenberg, 1995, CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues, Endocrinology, 136, 4139, 10.1210/en.136.9.4139
Lovenberg, 1995, Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain, Proc. Natl. Acad. Sci. U.S.A., 92, 836, 10.1073/pnas.92.3.836
Lu, 1986, Central versus peripheral effects of bombesin on the release of gastrointestinal hormones in dogs, J. Neurosci. Res., 16, 553, 10.1002/jnr.490160310
Ludwig, 2001, Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance, J. Clin. Invest., 107, 379, 10.1172/JCI10660
Luttinger, 1982, The effect of neurotensin on food consumption in the rat, Eur. J. Pharmacol., 81, 499, 10.1016/0014-2999(82)90116-9
Lutz, 1998, Amylin reduces food intake more potently than calcitonin gene-related peptide (CGRP) when injected into the lateral brain ventricle in rats, Peptides, 19, 1533, 10.1016/S0196-9781(98)00114-4
Lutz, 2000, Amylin receptors mediate the anorectic action of salmon calcitonin (sCT), Peptides, 21, 233, 10.1016/S0196-9781(99)00208-9
MacLusky, 2000, Neuroendocrine function and response to stress in mice with complete disruption of glucagon-like peptide-1 receptor signaling, Endocrinology, 141, 752, 10.1210/en.141.2.752
Mantzoros, 1999, Leptin and the hypothalamus: neuroendocrine regulation of food intake [news], Mol. Psychiatry, 4, 7, 10.1038/sj.mp.4000497
Mantzoros, 2000, Role of leptin in reproduction, Ann. N.Y. Acad. Sci., 900, 174, 10.1111/j.1749-6632.2000.tb06228.x
Marks, 1990, Localization of insulin receptor mRNA in rat brain by in situ hybridization, Endocrinology, 127, 3234, 10.1210/endo-127-6-3234
Marsh, 1998, Role of the Y5 neuropeptide Y receptor in feeding and obesity, Nat. Med., 4, 718, 10.1038/nm0698-718
Matsumoto, 2002, Galanin-like peptide stimulates food intake in the rat, Neurosci. Lett., 322, 67, 10.1016/S0304-3940(01)02515-0
Mayfield, 2001, A role for the Agouti-related protein promoter in obesity and type 2 diabetes, Biochem. Biophys. Res. Commun., 287, 568, 10.1006/bbrc.2001.5600
Mazella, 1996, Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain, J. Neurosci., 16, 5613, 10.1523/JNEUROSCI.16-18-05613.1996
Mazella, 1998, The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor, J. Biol. Chem., 273, 26273, 10.1074/jbc.273.41.26273
McDonald, 1985, Galanin inhibits insulin secretion and induces hyperglycemia in dogs, Diabetes, 34, 192, 10.2337/diabetes.34.2.192
McDonald, 1979, Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue, Biochem. Biophys. Res. Commun., 90, 227, 10.1016/0006-291X(79)91614-0
McMinn, 2000, Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression, Am. J. Physiol. Regul. Integr. Comp. Physiol., 279, R695, 10.1152/ajpregu.2000.279.2.R695
Meguid, 2000, Hypothalamic dopamine and serotonin in the regulation of food intake, Nutrition, 16, 843, 10.1016/S0899-9007(00)00449-4
Mercer, 1996, Localization of leptin receptor mRNA and the long form splice variant (Ob–Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization, FEBS Lett., 387, 113, 10.1016/0014-5793(96)00473-5
Mihaly, 2000, Hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the human hypothalamus are innervated by neuropeptide Y, agouti-related protein, and alpha-melanocyte-stimulating hormone, J. Clin. Endocrinol. Metab., 85, 2596, 10.1210/jc.85.7.2596
Miltenberger, 1997, The role of the agouti gene in the yellow obese syndrome, J. Nutr., 127, 1902S, 10.1093/jn/127.9.1902S
Miyasaka, 1994, Lack of satiety effect of cholecystokinin (CCK) in a new rat model not expressing the CCK-A receptor gene, Neurosci. Lett., 180, 143, 10.1016/0304-3940(94)90507-X
Mizuno, 1998, Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin, Diabetes, 47, 294, 10.2337/diabetes.47.2.294
Moller, 1999, Anxiogenic-like action of galanin after intra-amygdala administration in the rat, Neuropsychopharmacology, 21, 507, 10.1016/S0893-133X(98)00102-X
Moran, 2000, Cholecystokinin and satiety: current perspectives, Nutrition, 16, 858, 10.1016/S0899-9007(00)00419-6
Moran, 1992, Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK, Am. J. Physiol., 262, R46
Moran, 1982, Cholecystokinin suppresses food intake by inhibiting gastric emptying, Am. J. Physiol., 242, R491
Moran, 1986, Two brain cholecystokinin receptors: implications for behavioral actions, Brain Res., 362, 175, 10.1016/0006-8993(86)91413-7
Mori, 2000, Kidney produces a novel acylated peptide, ghrelin, FEBS Lett., 486, 213, 10.1016/S0014-5793(00)02308-5
Morley, 1987, Neuropeptide regulation of appetite and weight, Endocr. Rev., 8, 256, 10.1210/edrv-8-3-256
Morley, 1980, Thyrotropin releasing hormone (TRH) suppresses stress induced eating, Life Sci., 27, 269, 10.1016/0024-3205(80)90147-2
Morley, 1985, Peptide YY (PYY), a potent orexigenic agent, Brain Res., 341, 200, 10.1016/0006-8993(85)91490-8
Mountjoy, 1992, The cloning of a family of genes that encode the melanocortin receptors, Science, 257, 1248, 10.1126/science.1325670
Muff, 1995, Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin: homologous peptides, separate receptors and overlapping biological actions, Eur. J. Endocrinol., 133, 17, 10.1530/eje.0.1330017
Muff, 1999, An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3, Endocrinology, 140, 2924, 10.1210/en.140.6.2924
Muglia, 1995, Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need, Nature, 373, 427, 10.1038/373427a0
Muller, 2000, Disruption of feeding behavior in CRH receptor 1-deficient mice is dependent on glucocorticoids, Neuroreport, 11, 1963, 10.1097/00001756-200006260-00031
Munroe, 1999, Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2, Proc. Natl. Acad. Sci. U.S.A., 96, 1569, 10.1073/pnas.96.4.1569
Myers, 1986, CCK and other peptides modulate hypothalamic norepinephrine release in the rat: dependence on hunger or satiety, Brain Res. Bull., 17, 583, 10.1016/0361-9230(86)90229-7
Nagata, 1996, G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo, Proc. Natl. Acad. Sci. U.S.A., 93, 11825, 10.1073/pnas.93.21.11825
Nahon, 1989, The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus, Endocrinology, 125, 2056, 10.1210/endo-125-4-2056
Nakazato, 2001, A role for ghrelin in the central regulation of feeding, Nature, 409, 194, 10.1038/35051587
Nambu, 1999, Distribution of orexin neurons in the adult rat brain, Brain Res., 827, 243, 10.1016/S0006-8993(99)01336-0
Nauck, 1997, Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans, Am. J. Physiol., 273, E981
Navarro, 1996, Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake, J. Neurochem., 67, 1982, 10.1046/j.1471-4159.1996.67051982.x
Naveilhan, 1999, Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor, Nat. Med., 5, 1188, 10.1038/13514
Nijenhuis, 2001, AgRP(83–132) acts as an inverse agonist on the human-melanocortin-4 receptor, Mol. Endocrinol., 15, 164, 10.1210/me.15.1.164
Nijsen, 2000, Relevance of the C-terminal Arg–Phe sequence in gamma(2)-melanocyte-stimulating hormone (gamma(2)-MSH) for inducing cardiovascular effects in conscious rats, Br. J. Pharmacol., 131, 1468, 10.1038/sj.bjp.0703709
Nishijo, 1998, Gustatory and multimodal neuronal responses in the amygdala during licking and discrimination of sensory stimuli in awake rats, J. Neurophysiol., 79, 21, 10.1152/jn.1998.79.1.21
Nishimori, 1996, Oxytocin is required for nursing but is not essential for parturition or reproductive behavior, Proc. Natl. Acad. Sci. U.S.A., 93, 11699, 10.1073/pnas.93.21.11699
O’Doherty, 2000, Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex, Neuroreport, 11, 893, 10.1097/00001756-200003200-00046
Ohki-Hamazaki, 1999, Functional properties of two bombesin-like peptide receptors revealed by the analysis of mice lacking neuromedin B receptor, J. Neurosci., 19, 948, 10.1523/JNEUROSCI.19-03-00948.1999
Ohki-Hamazaki, 1997, Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity, Nature, 390, 165, 10.1038/36568
Ohta, 2000, Mechanism of delayed gastric emptying in naturally occurring CCK-A receptor gene knockout (OLETF) rats, Jpn. J. Physiol., 50, 443, 10.2170/jjphysiol.50.443
Oki, 1998, Distribution and concentration of urocortin, and effect of adrenalectomy on its content in rat hypothalamus, Life Sci., 62, 807, 10.1016/S0024-3205(97)01182-X
Oku, 1984, Cholecystokinin, bombesin and neurotensin in brain tissue from obese animals, Int. J. Obes., 8, 171
Ollmann, 1997, Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein, Science, 278, 135, 10.1126/science.278.5335.135
Olson, 1991, Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats, Peptides, 12, 113, 10.1016/0196-9781(91)90176-P
Olson, 1991, Brain oxytocin receptors mediate corticotropin-releasing hormone-induced anorexia, Am. J. Physiol., 260, R448
Orskov, 1989, Complete sequences of glucagon-like peptide-1 from human and pig small intestine, J. Biol. Chem., 264, 12826, 10.1016/S0021-9258(18)51561-1
Otto, 2001, Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa, Eur. J. Endocrinol., 145, 669, 10.1530/EJE-1450669
Parrott, 1994, Central effects of CCK ligands in pigs making operant responses for food, Pharmacol. Biochem. Behav., 49, 463, 10.1016/0091-3057(94)90056-6
Pelleymounter, 1995, Effects of the obese gene product on body weight regulation in ob/ob mice, Science, 269, 540, 10.1126/science.7624776
Peruzzo, 2000, A second look at the barriers of the medial basal hypothalamus, Exp. Brain Res., 132, 10, 10.1007/s002219900289
Peyron, 1998, Neurons containing hypocretin (orexin) project to multiple neuronal systems, J. Neurosci., 18, 9996, 10.1523/JNEUROSCI.18-23-09996.1998
Piper, 2000, The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats, Eur. J. Neurosci., 12, 726, 10.1046/j.1460-9568.2000.00919.x
Primus, 1997, Autoradiographic localization of CRF1 and CRF2 binding sites in adult rat brain, Neuropsychopharmacology, 17, 308, 10.1016/S0893-133X(97)00071-7
Qu, 1996, A role for melanin-concentrating hormone in the central regulation of feeding behaviour, Nature, 380, 243, 10.1038/380243a0
Rada, 1998, Galanin in the hypothalamus raises dopamine and lowers acetylcholine release in the nucleus accumbens: a possible mechanism for hypothalamic initiation of feeding behavior, Brain Res., 798, 1, 10.1016/S0006-8993(98)00315-1
Raikhinstein, 1994, cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor, Biochim. Biophys. Acta, 1220, 329, 10.1016/0167-4889(94)90157-0
Redei, 1998, A novel endogenous corticotropin release inhibiting factor, Ann. N.Y. Acad. Sci., 840, 456, 10.1111/j.1749-6632.1998.tb09584.x
Reyes, 2001, Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors, Proc. Natl. Acad. Sci. U.S.A., 98, 2843, 10.1073/pnas.051626398
Robinson, 1994, Evidence that p21ras mediates the neurotrophic effects of insulin and insulin-like growth factor I in chick forebrain neurons, Endocrinology, 135, 2568, 10.1210/en.135.6.2568
Rodriguez-Sinovas, 1997, CCK is involved in both peripheral and central mechanisms controlling food intake in chickens, Am. J. Physiol., 272, R334
Rogers, 1987, Oxytocin, oxytocin antagonist, TRH, and hypothalamic paraventricular nucleus stimulation effects on gastric motility, Peptides, 8, 505, 10.1016/0196-9781(87)90017-9
Rokaeus, 1984, A galanin-like peptide in the central nervous system and intestine of the rat, Neurosci. Lett., 47, 161, 10.1016/0304-3940(84)90423-3
Rossi, 1998, A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo, Endocrinology, 139, 4428, 10.1210/en.139.10.4428
Roussel, 1991, A prepro-TRH connecting peptide (prepro-TRH 160–169) potentiates TRH-induced TSH release from rat perifused pituitaries by stimulating dihydropyridine- and omega-conotoxin-sensitive Ca2+ channels, Neuroendocrinology, 54, 559, 10.1159/000125960
Rushing, 2001, Inhibition of central amylin signaling increases food intake and body adiposity in rats, Endocrinology, 142, 5035, 10.1210/en.142.11.5035
Rushing, 2000, Amylin: a novel action in the brain to reduce body weight, Endocrinology, 141, 850, 10.1210/en.141.2.850
Sahu, 2001, Evidence that neurotensin mediates the central effect of leptin on food intake in rat, Brain Res., 888, 343, 10.1016/S0006-8993(00)03107-3
Sahu, 1988, Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: implication in feeding behavior, Brain Res., 457, 376, 10.1016/0006-8993(88)90710-X
Sailer, 2001, Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R, Proc. Natl. Acad. Sci. U.S.A., 98, 7564, 10.1073/pnas.121170598
Saito, 1999, Molecular characterization of the melanin-concentrating-hormone receptor, Nature, 400, 265, 10.1038/22321
Sakanaka, 1986, Distribution and efferent projections of corticotropin-releasing factor-like immunoreactivity in the rat amygdaloid complex, Brain Res., 382, 213, 10.1016/0006-8993(86)91332-6
Sakurai, 1998, Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior [comment], Cell, 92, 1, 10.1016/S0092-8674(00)80949-6
Schuit, 2001, Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus, Diabetes, 50, 1, 10.2337/diabetes.50.1.1
Schulingkamp, 2000, Insulin receptors and insulin action in the brain: review and clinical implications, Neurosci. Biobehav. Rev., 24, 855, 10.1016/S0149-7634(00)00040-3
Schwartz, 1992, Insulin in the brain: a hormonal regulator of energy balance, Endocr. Rev., 13, 387
Schwartz, 1996, Identification of targets of leptin action in rat hypothalamus, J. Clin. Invest., 98, 1101, 10.1172/JCI118891
Schwartz, 1992, Inhibition of hypothalamic neuropeptide Y gene expression by insulin, Endocrinology, 130, 3608, 10.1210/en.130.6.3608
Scrocchi, 1996, Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene, Nat. Med., 2, 1254, 10.1038/nm1196-1254
Sexton, 1994, In vitro autoradiographic localization of amylin binding sites in rat brain, Neuroscience, 62, 553, 10.1016/0306-4522(94)90388-3
Shintani, 2001, Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway, Diabetes, 50, 227, 10.2337/diabetes.50.2.227
Shioda, 1993, Medullary synaptic inputs to thyrotropin-releasing hormone (TRH)-containing neurons in the hypothalamus: an ultrastructural study combining WGA-HRP anterograde tracing with TRH immunocytochemistry, Brain Res., 625, 9, 10.1016/0006-8993(93)90131-6
Shiraishi, 2000, Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons, Physiol. Behav., 71, 251, 10.1016/S0031-9384(00)00341-3
Shutter, 1997, Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice, Genes Dev., 11, 593, 10.1101/gad.11.5.593
Small, 2001, Effects of chronic central nervous system administration of agouti-related protein in pair-fed animals, Diabetes, 50, 248, 10.2337/diabetes.50.2.248
Spanswick, 1997, Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels, Nature, 390, 521, 10.1038/37379
Spina, 1996, Appetite-suppressing effects of urocortin, a CRF-related neuropeptide, Science, 273, 1561, 10.1126/science.273.5281.1561
Spindel, 1990, Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor, Mol. Endocrinol., 4, 1956, 10.1210/mend-4-12-1956
Stanley, 1986, Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity, Peptides, 7, 1189, 10.1016/0196-9781(86)90149-X
Stanley, 1985, Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior, Proc. Natl. Acad. Sci. U.S.A., 82, 3940, 10.1073/pnas.82.11.3940
Stanley, 2001, Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo–pituitary axes in vitro and in vivo in male rats, Brain Res., 893, 186, 10.1016/S0006-8993(00)03312-6
Steiner, 2001, Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer’s disease, Proc. Natl. Acad. Sci. U.S.A., 98, 4184, 10.1073/pnas.061445598
Stenzel-Poore, 1992, Development of Cushing’s syndrome in corticotropin-releasing factor transgenic mice, Endocrinology, 130, 3378, 10.1210/en.130.6.3378
Stubdal, 2000, Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation, Mol. Cell Biol., 20, 878, 10.1128/MCB.20.3.878-882.2000
Sunter, 2001, Orexins: effects on behavior and localisation of orexin receptor 2 messenger ribonucleic acid in the rat brainstem, Brain Res., 907, 27, 10.1016/S0006-8993(01)02344-7
Suzuki, 1982, Intracranial injection of thyrotropin releasing hormone (TRH) suppresses starvation-induced feeding and drinking in rats, Pharmacol. Biochem. Behav., 17, 249, 10.1016/0091-3057(82)90078-8
Szekely, 2002, Effects of orexins on energy balance and thermoregulation, Regul. Pept., 104, 47, 10.1016/S0167-0115(01)00348-2
Tanaka, 1990, Structure and functional expression of the cloned rat neurotensin receptor, Neuron, 4, 847, 10.1016/0896-6273(90)90137-5
Tang-Christensen, 2000, The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake, Nat. Med., 6, 802, 10.1038/77535
Tartaglia, 1995, Identification and expression cloning of a leptin receptor, Ob-R, Cell, 83, 1263, 10.1016/0092-8674(95)90151-5
Thiele, 1997, Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats, Am. J. Physiol., 272, R726
Thim, 1999, Tissue-specific processing of cocaine- and amphetamine-regulated transcript peptides in the rat, Proc. Natl. Acad. Sci. U.S.A., 96, 2722, 10.1073/pnas.96.6.2722
Timpl, 1998, Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1 [see comments], Nat. Genet., 19, 162, 10.1038/520
Toshinai, 2001, Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration, Biochem. Biophys. Res. Commun., 281, 1220, 10.1006/bbrc.2001.4518
Trivedi, 1998, Distribution of orexin receptor mRNA in the rat brain, FEBS Lett., 438, 71, 10.1016/S0014-5793(98)01266-6
Tsai, 1997, Intestinal growth-promoting properties of glucagon-like peptide-2 in mice, Am. J. Physiol., 273, E77
Tsujii, 1989, Acetylation alters the feeding response to MSH and beta-endorphin, Brain Res. Bull., 23, 165, 10.1016/0361-9230(89)90142-1
Turton, 1996, A role for glucagon-like peptide-1 in the central regulation of feeding, Nature, 379, 69, 10.1038/379069a0
Uehara, 1998, Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin, Diabetes, 47, 890, 10.2337/diabetes.47.6.890
Vaisse, 1998, A frameshift mutation in human MC4R is associated with a dominant form of obesity, Nat. Genet., 20, 113, 10.1038/2407
Vaisse, 1996, Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice, Nat. Genet., 14, 95, 10.1038/ng0996-95
Van Bergen, 1995, Cardiovascular effects of gamma-MSH/ACTH-like peptides: structure–activity relationship, Eur. J. Pharmacol., 294, 795, 10.1016/0014-2999(95)00657-5
van Dijk, 1999, Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat, Am. J. Physiol, 276, R1425
van Dijk, 1996, Central infusions of leptin and GLP-1-(7–36) amide differentially stimulate c-FLI in the rat brain, Am. J. Physiol., 271, R1096
Vaughan, 1995, Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor, Nature, 378, 287, 10.1038/378287a0
Verbalis, 1991, Oxytocin produces natriuresis in rats at physiological plasma concentrations, Endocrinology, 128, 1317, 10.1210/endo-128-3-1317
Vergoni, 1999, Corticotropin-releasing factor (CRF) induced anorexia is not influenced by a melanocortin 4 receptor blockage, Peptides, 20, 509, 10.1016/S0196-9781(99)00022-4
Vergoni, 1986, Corticotropin inhibits food intake in rats, Neuropeptides, 7, 153, 10.1016/0143-4179(86)90091-0
Versteeg, 1998, Melanocortins and cardiovascular regulation, Eur. J. Pharmacol., 360, 1, 10.1016/S0014-2999(98)00615-3
Vijayan, 1977, Suppression of feeding and drinking activity in rats following intraventricular injection of thyrotropin releasing hormone (TRH), Endocrinology, 100, 1727, 10.1210/endo-100-6-1727
Von Schrenck, 1989, Neuromedin B receptor in esophagus: evidence for subtypes of bombesin receptors, Am. J. Physiol., 256, G747
Vrang, 1999, Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour, Brain Res., 818, 499, 10.1016/S0006-8993(98)01349-3
Wang, 2000, Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression, Neuroreport, 11, 3251, 10.1097/00001756-200009280-00040
Wang, 2000, Synergistic interaction between CCK and leptin to regulate food intake, Regul. Pept., 92, 79, 10.1016/S0167-0115(00)00153-1
Wang, 1997, Molecular cloning and pharmacological characterization of a new galanin receptor subtype, Mol. Pharmacol., 52, 337, 10.1124/mol.52.3.337
Wellman, 2000, Norepinephrine and the control of food intake, Nutrition, 16, 837, 10.1016/S0899-9007(00)00415-9
Wiegant, 1979, Intracerebroventricular ACTH activates the pituitary–adrenal system: dissociation from a behavioral response, Life Sci., 25, 1791, 10.1016/0024-3205(79)90425-9
Wikstrom, 1998, Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1, EMBO J., 17, 455, 10.1093/emboj/17.2.455
Wilding, 1993, Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse, Endocrinology, 132, 1939, 10.1210/en.132.5.1939
Williams, 1991, Reduced hypothalamic neurotensin concentrations in the genetically obese diabetic (ob/ob) mouse: possible relationship to obesity, Metabolism, 40, 1112, 10.1016/0026-0495(91)90139-N
Wirth, 2000, Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding, Peptides, 21, 1369, 10.1016/S0196-9781(00)00280-1
Woods, 1998, Signals that regulate food intake and energy homeostasis, Science, 280, 1378, 10.1126/science.280.5368.1378
Wren, 2001, Ghrelin causes hyperphagia and obesity in rats, Diabetes, 50, 2540, 10.2337/diabetes.50.11.2540
Wren, 2000, The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion, Endocrinology, 141, 4325, 10.1210/en.141.11.4325
Wynick, 1998, Galanin regulates prolactin release and lactotroph proliferation, Proc. Natl. Acad. Sci. U.S.A., 95, 12671, 10.1073/pnas.95.21.12671
Xu, 1999, Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: effects of food restriction, Endocrinology, 140, 2868, 10.1210/en.140.6.2868
Yamada, 1999, Human thyrotropin-releasing hormone-associated peptide 3 (hTAP-3) in serum, Endocr. J., 46, 675, 10.1507/endocrj.46.675
Yamada, 1997, Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene, Proc. Natl. Acad. Sci. U.S.A., 94, 10862, 10.1073/pnas.94.20.10862
Yamamoto, 2000, Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese mice, Brain Res. Bull., 51, 515, 10.1016/S0361-9230(99)00271-3
Yaswen, 1999, Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin [see comments], Nat. Med., 5, 1066, 10.1038/12506
Yeo, 1998, A frameshift mutation in MC4R associated with dominantly inherited human obesity, Nat. Genet., 20, 111, 10.1038/2404
Zhang, 1994, Positional cloning of the mouse obese gene and its human homologue, Nature, 372, 425, 10.1038/372425a0