Neuropeptide Y Distribution in the Rat Brain

American Association for the Advancement of Science (AAAS) - Tập 221 Số 4613 - Trang 877-879 - 1983
Y.S. Allen1, Thomas E. Adrian2, J.M. Allen2, Kazuhiko Tatemoto3, T.J. Crow4, S.R. Bloom2, J.M. Polak1
1Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 OHS, United Kingdom
2Department of Medicine, School, Hammersmith Hospital, London W12 OHS, United Kingdom
3Department of Biochemistry II, Karolinska Institute, S-104 01 Stockholm, Sweden
4Division of Psychiatry, Clinical Research Centre, Harrow, Middlesex HAI 3UJ, United Kingdom

Tóm tắt

A massive neuronal system was detected by immunocytochemistry and radioimmunoassay with antibodies to neuropeptide Y, the recently isolated peptide of the pancreatic polypeptide family. Immunoreactive cell bodies and fibers were most prevalent in cortical, limbic, and hypothalamic regions. Neuropeptide Y was extracted in concentrations higher than those of any other peptide hitherto discovered in the mammalian brain. Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for immunostaining of pancreatic polypeptide-like immunoreactivity in the mammalian brain.

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Tài liệu tham khảo

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American Association for the Advancement of Science (AAAS)

Tập 221 Số 4613

877-879

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