Nasal proteosome subunit flu vaccine elicits enhanced mucosal IgA, serum HAI and protection comparable to conventional injectable flu vaccine

International Congress Series - Tập 1219 - Trang 979-984 - 2001
M Plante1, D Jones1, F Allard1, K Torossian1, J Gauthier1, G White1, G Lowell1, D Burt1
1Intellivax International Inc., 7150 Frederick Banting, Suite 200, Ville St-Laurent, Québec, Canada H4S 2A1

Tài liệu tham khảo

Cox, 1999, Influenza, Lancet, 354, 1277, 10.1016/S0140-6736(99)01241-6 Edwards, 1994, A randomized controlled trial of cold-adapted and inactivated vaccines for the prevention of influenza A disease, J. Infect. Dis., 169, 68, 10.1093/infdis/169.1.68 Moldoveanu, 1995, Human immune responses to influenza virus vaccines administered by systemic or mucosal routes, Vaccine, 13, 1006, 10.1016/0264-410X(95)00016-T Fulk, 1969, Antibody responses in children and elderly persons following local or parenteral administration of an inactivated influenza virus vaccine, A2/Hong Kong/68 variant, J. Immunol., 102, 1102, 10.4049/jimmunol.102.4.1102 Wright, 1983, Secretory immunological response after intranasal inactivated influenza virus vaccinations: evidence for immunoglobulin A memory, Infect. Immun., 40, 1092, 10.1128/IAI.40.3.1092-1095.1983 Boyce, 2000, Safety and immunogenicity of adjuvanted and unadjuvanted subunit influenza vaccines administered to healthy adults, Vaccine, 19, 217, 10.1016/S0264-410X(00)00171-7 Lowell, 1996, Intranasal and intramuscular proteosome-staphylococcal enterotoxin B (SEB) toxoid vaccine: immunogenicity and efficacy against lethal SEB intoxication in mice, Infect. Immun., 64, 1706, 10.1128/IAI.64.5.1706-1713.1996 Orr, 1993, Immunogenicity and efficacy of oral or intranasal Shigelle flexneri 2a and Shigella sonnei proteosome-lipopolysaccharide vaccines in animal models, Infect. Immun., 61, 2390, 10.1128/IAI.61.6.2390-2395.1993 Orr, 1994, Enhancement of anti-Shigella lipopolysaccharide (LPS) response by addition of the cholera toxin B subunit to oral and intranasal proteosome-Shigella flexneri 2a LPS vaccine, Infect. Immun., 62, 5198, 10.1128/IAI.62.11.5198-5200.1994 Mallett, 1995, Intranasal or intragastric immunization with proteosome-Shigella lipopolysaccharide vaccines protects against lethal pneumonia in a murine model of Shigella infection, Infect. Immun., 63, 2382, 10.1128/IAI.63.6.2382-2386.1995 Lowell, 1997, Proteosomes, emulsomes, and cholera toxin B improve nasal immunogenicity of human immunodeficiency virus gp160 in mice: induction of serum, intestinal, vaginal, and lung IgA and IgG, J. Infect. Dis., 175, 292, 10.1093/infdis/175.2.292 VanCott, 1998, HIV-1 neutralizing antibodies in the genital and respiratory tracts of mice intranasally immunized with oligomeric gp160, J. Immunol., 160, 2000, 10.4049/jimmunol.160.4.2000 Chisari, 1995, Hepatitis B virus immunopathogenesis, Ann. Rev. Immunol., 13, 29, 10.1146/annurev.iy.13.040195.000333