NF- κ B Independent Suppression of Endothelial Vascular Cell Adhesion Molecule-1 and Intercellular Adhesion Molecule-1 Gene Expression by Inhibition of Flavin Binding Proteins and Superoxide Production

Journal of Molecular and Cellular Cardiology - Tập 32 - Trang 1499-1508 - 2000
Pradyumna E Tummala1, Xi-Lin Chen1, Russell M Medford1,2
1Division of Cardiology, Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
2AtheroGenics, Inc, Alpharetta, GA 30004, USA

Tài liệu tham khảo

Staunton, 1988, Primary structure of ICAM-1 demonstrates interaction between members of immunoglobulin and integrin supergene families, Cell, 52, 925, 10.1016/0092-8674(88)90434-5 Poston, 1992, Expression of intercellular adhesion molecule-1 in atherosclerotic plaques, Am J Pathol, 140, 665 Li, 1993, An atheroÍgenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium, Arterio Thromb, 13, 197, 10.1161/01.ATV.13.2.197 Cybulsky, 1991, Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis, Science, 251, 788, 10.1126/science.1990440 Carlos, 1991, Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1, Blood, 77, 2266, 10.1182/blood.V77.10.2266.2266 Marui, 1993, Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells, J Clin Invest, 92, 1866, 10.1172/JCI116778 Weber, 1994, Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals, Arterio Thromb, 14, 1665, 10.1161/01.ATV.14.10.1665 Iademarco, 1992, Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1), J Biol Chem, 267, 16323, 10.1016/S0021-9258(18)42004-2 Voraberger, 1991, Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region. Induction by cytokines and phorbol ester, J Immunol, 147, 2777, 10.4049/jimmunol.147.8.2777 Wolin, 1996, Reactive oxygen species and vascular signal transduction mechanisms, Microcirculation, 3, 1, 10.3109/10739689609146778 Agwu, 1991, Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase, J Clin Invest, 88, 531, 10.1172/JCI115336 Parthasarathy, 1989, A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein, Proc Natl Acad Sci USA, 86, 1046, 10.1073/pnas.86.3.1046 Morre, 1994, Hormone- and growth factor-stimulated NADH oxidase, J Bioenerg Biomembr, 26, 421, 10.1007/BF00762783 Pagano, 1995, An NADPH oxidase superoxide-generating system in the rabbit aorta, Am J Physiol, 268, H2274 Ohara, 1993, HyperÍcholesterolemia increases endothelial superoxide anion production, J Clin Invest, 91, 2546, 10.1172/JCI116491 Ohara, 1995, Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production, Circulation, 92, 898, 10.1161/01.CIR.92.4.898 Satriano, 1993, J Clin Invest, 92, 1564, 10.1172/JCI116737 Mohazzab, 1994, NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium, Am J Physiol, 266, H2568 Gyllenhammar, 1987, Lucigenin chemiluminescence in the assessment of neutrophil superoxide production, J Immunol Methods, 97, 209, 10.1016/0022-1759(87)90461-3 Rajagopalan, 1996, Angiotensin II mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation: contribution to alterations of vasomotor tone, J Clin Invest, 97, 1916, 10.1172/JCI118623 Dignam, 1983, Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei, Nuc Acid Res, 11, 1476, 10.1093/nar/11.5.1475 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal Biochem, 72, 248, 10.1016/0003-2697(76)90527-3 Ahmad, 1995, Cell type-specific transactivation of the VCAM-1 promoter through an NF-kappa B enhancer motif, J Biol Chem, 270, 8976, 10.1074/jbc.270.15.8976 Kunsch, 1992, Selection of optimal κ B/rel DNA-binding motifs: interaction of both subunits of NF- κ B with DNA is required for transcriptional activation, Mol Cel Biol, 12, 4412, 10.1128/MCB.12.10.4412 O»Donnell, 1993, Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase, Biochem J, 290, 41, 10.1042/bj2900041 O»Donnell, 1994, Involvement of phenyl radicals in iodonium inhibition of flavoÍenzymes, Mol Pharmacol, 46, 778 Offermann, 1995, Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells, Eur J Biochem, 232, 28, 10.1111/j.1432-1033.1995.tb20777.x Bochner, 1991, Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules, J Exp Med, 173, 1553, 10.1084/jem.173.6.1553 Carlos, 1990, Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells [published erratum appears in Blood 1990 Dec 1; 76(11): 2420], Blood, 76, 965, 10.1182/blood.V76.5.965.965 Iademarco, 1995, Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells, J Clin Invest, 95, 264, 10.1172/JCI117650 Wertheimer, 1992, Intercellular adhesion molecule-1 gene expression in human endothelial cells: differential regulation by tumor necrosis factor- α and phorbol myristate acetate, J Biol Chem, 267, 12030, 10.1016/S0021-9258(19)49801-3 Baeuerle, 1996, Reactive oxygen intermediates as second messengers of a general pathogen response, Pathol Biol (Paris), 44, 29 Schreck, 1992, Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells [Review], Free Radical Res Commun, 17, 221, 10.3109/10715769209079515 Pahl, 1996, Activation of NF-kappa B by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers, FEBS Lett, 392, 129, 10.1016/0014-5793(96)00800-9 Schreck, 1991, A role for oxygen radicals as second messengers, Trends Cell Biol, 1, 39, 10.1016/0962-8924(91)90072-H Pagani, 1995, An NADH oxidase speroxide-generating system in rabbit aorta, Am J Physiol, 268, H2274 Mohazzab, 1994, NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium, Am J Physiol, 266, H2568 Bonizzi, 1999, Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity, Mol Cell Biol, 19, 1950, 10.1128/MCB.19.3.1950 Schreck, 1992, Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells, J Exp Med, 175, 1181, 10.1084/jem.175.5.1181 Wolle, 1996, Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on transcription factor NF-kappa B, Arterioscler Thromb Vasc Biol, 16, 1501, 10.1161/01.ATV.16.12.1501 Gerritsen, 1995, Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression [see comments], Am J Pathol, 147, 278 Miesel, 1996, Suppression of inflammatory arthritis by simultaneous inhibition of nitric oxide synthase and NADPH oxidase, Free Radic Biol Med, 20, 75, 10.1016/0891-5849(95)02026-8 Khan, 1996, Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells, Proc Natl Acad Sci USA, 93, 9114, 10.1073/pnas.93.17.9114 Majander, 1994, DiphenylÍeneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I), J Biol Chem, 269, 21037, 10.1016/S0021-9258(17)31926-9