Myocardial viability as a determinant of the ejection fraction response to carvedilol in patients with heart failure (CHRISTMAS trial): randomised controlled trial

Packer, 2001, Effect of carvedilol on survival in severe chronic heart failure, N Engl J Med, 344, 1651, 10.1056/NEJM200105313442201

1999, The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial, Lancet, 353, 9, 10.1016/S0140-6736(98)11181-9

1999, Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF), Lancet, 353, 2001, 10.1016/S0140-6736(99)04440-2

Cleland, 1996, Beta-blocking agents in heart failure: should they be used and how, Eur Heart J, 17, 1629, 10.1093/oxfordjournals.eurheartj.a014745

Cleland, 1999, Sudden death in heart failure: vascular or electrical, Eur J Heart Fail, 1, 41, 10.1016/S1388-9842(99)00009-4

Doughty, 1997, Left ventricular remodelling with carvedilol in patients with congestive heart failure due to ischemic heart disease, J Am CollCardiol, 29, 1060, 10.1016/S0735-1097(97)00012-0

Bristow, 1998, Why does the myocardium fail? Insights from basic science, Lancet, 352, 8, 10.1016/S0140-6736(98)90311-7

Cleland, 2002, How to assess new treatments for the management of heart failure: composite scoring systems to assess the patients' clinical journey, Eur J Heart Fail, 4, 243, 10.1016/S1388-9842(02)00039-9

O'Keefe, 2000, Predictors of improvement in left ventricular ejection fraction with carvedilol for congestive heart failure, J Nucl Cardiol, 7, 3, 10.1067/mnc.2000.102678

Bristow, 1996, Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure, Circulation, 94, 2807, 10.1161/01.CIR.94.11.2807

Woodley, 1991, Beta-blockade with bucindolol in heart failure caused by ischemic versus idiopathic dilated cardiomyopathy, Circulation, 84, 2426, 10.1161/01.CIR.84.6.2426

Packer, 2001, Comparative effects of carvedilol and metoprolol on left ventricular ejection fraction in heart failure: results of a meta-analysis, Am Heart J, 141, 899, 10.1067/mhj.2001.115584

Unverferth, 1983, The role of subendocardial ischemia in perpetuating myocardial failure in patients with non-ischemic congestive cardiomyopathy, Am Heart J, 105, 176, 10.1016/0002-8703(83)90305-8

Medrano, 1996, Assessment of myocardial viability with (99m)Tc sestamibi in patients undergoing cardiac transplantation: a scintigraphic/pathological study, Circulation, 94, 1010, 10.1161/01.CIR.94.5.1010

Fisher, 1994, Beneficial effects of metoprolol in heart failure associated with coronary artery disease: a randomized trial, J Am Coll Cardiol, 23, 943, 10.1016/0735-1097(94)90641-6

Cleland, 1999, The Carvedilol Hibernation Reversible Ischaemia Trial: marker of success (CHRISTMAS), Eur J Heart Fail, 1, 191, 10.1016/S1388-9842(99)00024-0

Pennell, 2000, The Carvedilol Hibernation Reversible Ischaemia Trial: Marker of Success (CHRISTMAS) study—methodology of a randomised, placebo controlled, multicentre study of carvedilol in hibernation and heart failure, Int J Cardiol, 72, 265, 10.1016/S0167-5273(99)00198-9

Kloner, 1998, Medical and cellular implications of stunning, hibernation, and preconditioning: an NHLBI Workshop, Circulation, 97, 1848, 10.1161/01.CIR.97.18.1848

Canty, 2000, Chronic hibernation and chronic stunning: a continuum, J Nucl Cardiol, 7, 509, 10.1067/mnc.2000.109683

Kaprielian, 1998, Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle, Circulation, 97, 651, 10.1161/01.CIR.97.7.651

Schwartz, 1998, Prolonged myocardial hibernation exacerbates cardiomyocyte degeneration and impairs recovery of function after revascularization, J Am Coll Cardiol, 31, 1018, 10.1016/S0735-1097(98)00041-2

Allman, 2002, Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis, J Am Coll Cardiol, 39, 1151, 10.1016/S0735-1097(02)01726-6

Cleland, 2003, The Heart Failure Revascularisation Trial (HEART): rationale, design and methodology, Eur J Heart Fail, 5, 295, 10.1016/S1388-9842(03)00056-4

Feuerstein, 1995, Carvedilol, a novel multiple action antihypertensive agent with antioxidant activity and the potential for myocardial and vascular protection, Eur Heart J, 16, 38, 10.1093/eurheartj/16.suppl_F.38

Chen, 1997, Myocardial cell death and apoptosis in hibernating myocardium, J Am Coll Cardiol, 30, 1407, 10.1016/S0735-1097(97)00309-4

Hall, 1995, Time course of improvement in left ventricular function, mass and geometry in patients with congestive heart failure treated with beta-adrenergic blockade, JAm Coll Cardiol, 25, 1154, 10.1016/0735-1097(94)00543-Y