So sánh tác động của myo-inositol và metformin đến đặc điểm lâm sàng, hồ sơ nội tiết và chuyển hóa ở phụ nữ vô sinh mắc hội chứng buồng trứng đa nang: Một thử nghiệm ngẫu nhiên có kiểm soát

Asian Pacific Journal of Reproduction - Tập 12 Số 6 - Trang 256-265 - 2023
Viết Nguyên Sa Lê1, Minh Tâm Lê2, Ngọc Thành Cao2
1Center for OBGYN, Hue Central Hospital, 16 Le Loi Street, Hue, Vietnam
2Center for Reproductive Endocrinology and Infertility, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam

Tóm tắt

Mục tiêu:

So sánh hiệu quả của myo-inositol và metformin trên các đặc điểm lâm sàng, và hồ sơ nội tiết và chuyển hóa của phụ nữ Việt Nam vô sinh mắc hội chứng buồng trứng đa nang (PCOS).

Phương pháp:

Từ tháng 6 năm 2018 đến tháng 8 năm 2022, một thử nghiệm ngẫu nhiên được tiến hành tại Trung tâm Nội tiết và Sinh sản Huế về các phụ nữ vô sinh từ 18 đến 40 tuổi mắc hội chứng buồng trứng đa nang. Các đặc điểm lâm sàng, nội tiết và chuyển hóa của những cá nhân này được đánh giá trước và sau 3 tháng điều trị bằng 2g myo-inositol hoặc 1700mg metformin mỗi ngày. Tỷ lệ mang thai tự nhiên, tác dụng phụ và sự dung nạp myo-inositol được ghi nhận.

Từ khóa

#myo-inositol #metformin #hội chứng buồng trứng đa nang #vô sinh #thử nghiệm y khoa

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