Sự giải oxy trong cơ bắp trong bài tập chạy xe đạp tăng dần ở người lớn tuổi bị tiểu đường type 2

Springer Science and Business Media LLC - Tập 124 Số 2 - Trang 561-571 - 2024
Adam McDermott1, Aaron Nevin1, Norita Gildea1, Joel Rocha2, Donal O’Shea3, Mikel Egaña1
1Department of Physiology, School of Medicine, Trinity College Dublin, The University of Dublin, Dublin 2, Ireland
2Dundee, UK
3Endocrinology, St Columcille’s and St Vincent’s Hospitals, Dublin, Ireland

Tóm tắt

Tóm tắt Mục đích Khám phá các hồ sơ về tỷ lệ giải oxy phân đoạn (sử dụng phổ gần hồng ngoại) trong quá trình tập xe đạp tăng dần ở những cá nhân lớn tuổi mắc tiểu đường type 2 (T2D). Phương pháp Mười hai cá nhân mắc T2D (tuổi trung bình ± SD, 63 ± 3 năm) và 12 người khỏe mạnh (tuổi trung bình: 65 ± 3 năm) đã hoàn thành bài tập xe đạp tăng dần. Tỷ lệ mất oxy ở cơ (có nghĩa là, hemoglobin và myoglobin không oxy hóa, Δ[HHb + Mb]) của cơ vastus lateralis đã được chuẩn hóa thành 100% phản ứng, vẽ theo công suất đầu ra tuyệt đối (W) và tương đối (%peak) và được khớp với một mô hình hồi quy tuyến tính bội số hai. Kết quả Lượng oxy tối đa đạt được (V̇O2peak) có sự giảm đáng kể (P < 0.01) ở những người mắc T2D (23.0 ± 4.2 ml.kg−1.min−1) so với nhóm đối chứng (28.3 ± 5.3 ml.kg−1.min−1). Độ dốc của đoạn tuyến tính đầu tiên của mô hình lớn hơn (tứ phân vị) ở T2D (1.06 (1.50)) so với nhóm đối chứng (0.79 (1.06)) khi Δ%[HHb + Mb] được vẽ dưới dạng hàm của công suất đầu ra (PO). Ngoài ra, sự khởi đầu của đoạn tuyến tính thứ hai của mô hình Δ%[HHb + Mb]/PO xảy ra ở cường độ tập thể dục thấp hơn ở T2D (101 ± 35 W) so với nhóm đối chứng (140 ± 34 W) và nó hiển thị một phản ứng gần như bình nguyên ở cả hai nhóm. Khi mối quan hệ của hồ sơ Δ%[HHb + Mb] được thể hiện dưới dạng hàm của %PO không quan sát thấy sự khác biệt ở bất kỳ tham số nào của mô hình hồi quy tuyến tính bội số hai. Kết luận Các phát hiện này gợi ý rằng những người lớn tuổi có T2D không biến chứng cho thấy sự giải oxy phân đoạn lớn hơn cho công suất đầu ra tuyệt đối nhất định so với những người lớn tuổi khỏe mạnh. Do đó, sự giảm trong V̇O2peak ở người lớn tuổi mắc T2D có thể bị ảnh hưởng bởi sự suy giảm trong việc cung cấp O2 vi mạch.

Từ khóa


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