Multidrug-resistant Klebsiella pneumoniae: genetic diversity, mechanisms of resistance to polymyxins and clinical outcomes in a tertiary teaching hospital in Brazil

Ícaro Boszczowski1, Matias Chiarastelli Salomão1, Luísa Moura1, Maristela Pinheiro Freire1, Thaís Guimarães1, Arlete Emily Cury2, Flávia Rossi2, Camila Rizek3, Roberta Cristina Ruedas Martins3, Sílvia Figueiredo Costa4
1Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas, Subcomissao de Controle de Infeccao Hospitalar, Sao Paulo, Sao Paulo, Brazil
2Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas, Divisao de Laboratorio Clinico, Sao Paulo, Sao Paulo, Brazil
3Universidade de Sao Paulo, Instituto de Medicina Tropical de Sao Paulo, Laboratorio de Investigacao Medica (LIM) 54, Sao Paulo, Sao Paulo, Brazil
4Universidade de Sao Paulo, Instituto de Medicina Tropical de Sao Paulo, Laboratorio de Investigacao Medica (LIM) 54, Sao Paulo, Sao Paulo, BrazilUniversidade de Sao Paulo, Faculdade de Medicina, Departamento de Molestias Infecciosas e Parasitarias, Sao Paulo, Sao Paulo, Brazil

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Monteiro J, 2009, First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil, Antimicrob Agents Chemother, 53, 333, 10.1128/AAC.00736-08

Pavez M, 2009, Early dissemination of KPC-2-producing Klebsiella pneumoniae strains in Brazil, Antimicrob Agents Chemother, 53, 10.1128/AAC.00089-09

Oliveira MS, 2015, Treatment of KPC-producing Enterobacteriaceae: suboptimal efficacy of polymyxins, Clin Microbiol Infect, 21, 179.e1, 10.1016/j.cmi.2014.07.010

Gomez-Simmonds A, 2016, Combination regimens for treatment of carbapenem-resistant Klebsiella pneumoniae bloodstream infections, Antimicrob Agents Chemother, 60, 3601, 10.1128/AAC.03007-15

Sampaio JL, 2016, Antimicrobial resistance in Enterobacteriaceae in Brazil: focus on β-lactams and polymyxins, Braz J Microbiol, 47, 31, 10.1016/j.bjm.2016.10.002

Rossi F, 2017, Emergence of colistin resistance in the largest university hospital complex of São Paulo, Brazil, over five years, Braz J Infect Dis, 21, 98, 10.1016/j.bjid.2016.09.011

Olaitan AO, 2014, Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria, Front Microbiol, 5, 10.3389/fmicb.2014.00643

2014

Zhang Z, 2018, Antimicrobial susceptibility among Gram-positive and Gram-negative blood-borne pathogens collected between 2012-2016 as part of the Tigecycline Evaluation and Surveillance Trial, Antimicrob Resist Infect Control, 7, 10.1186/s13756-018-0441-y

Antonelli A, 2016, Performance of the BD MAX™ instrument with Check-Direct CPE real-time PCR for the detection of carbapenemase genes from rectal swabs, in a setting with endemic dissemination of carbapenemase-producing Enterobacteriaceae, Diagn Microbiol Infect Dis, 86, 30, 10.1016/j.diagmicrobio.2016.06.002

Seemann T, 2014, Prokka: rapid prokaryotic genome annotation, Bioinformatics, 30, 2068, 10.1093/bioinformatics/btu153

Larsen MV, 2012, Multilocus sequence typing of total-genome-sequenced bacteria, J Clin Microbiol, 50, 1355, 10.1128/JCM.06094-11

Zankari E, 2012, Identification of acquired antimicrobial resistance genes, J Antimicrob Chemother, 67, 2640, 10.1093/jac/dks261

Elemam A, 2010, In vitro evaluation of antibiotic synergy for polymyxin B-resistant carbapenemase-producing Klebsiella pneumoniae, J Clin Microbiol, 48, 3558, 10.1128/JCM.01106-10

Mezzatesta ML, 2011, Outbreak of KPC-3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals, Clin Microbiol Infect, 17, 1444, 10.1111/j.1469-0691.2011.03572.x

Giani T, 2013, Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey, 15 May to 30 June 2011, Euro Surveill, 18, 10.2807/ese.18.22.20489-en

Falagas ME, 2005, Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections, Clin Infect Dis, 40, 1333, 10.1086/429323

Cannatelli A, 2013, In vivo emergence of colistin resistance in Klebsiella pneumoniae producing KPC-type carbapenemases mediated by insertional inactivation of the PhoQ/PhoPmgrB regulator, Antimicrob Agents Chemother, 57, 5521, 10.1128/AAC.01480-13

Cannatelli A, 2014, In vivo evolution to colistin resistance by PmrB sensor kinase mutation in KPC-producing Klebsiella pneumoniae associated with low-dosage colistin treatment, Antimicrob Agents Chemother, 58, 4399, 10.1128/AAC.02555-14

Jayol A, 2014, Resistance to colistin associated to a single amino acid change in protein PmrB among Klebsiella pneumoniae of worldwide origin, Antimicrob Agents Chemother, 58, 4762, 10.1128/AAC.00084-14

Kim SY, 2014, Differential expression of two-component systems, pmrAB and phoPQ, with different growth phases of Klebsiella pneumoniae in the presence or absence of colistin, Curr Microbiol, 69, 37, 10.1007/s00284-014-0549-0

Cassu-Corsi D, 2015, Misidentification of pan drug-resistant Klebsiella pneumoniae clinical isolates as a metallo-β-lactamase producers by the EDTA/DDTS test, Braz J Infect Dis, 19, 102, 10.1016/j.bjid.2014.08.008

Maio Carrilho CM, 2017, Colistin-resistant Enterobacteriaceae infections: clinical and molecular characterization and analysis of in vitro synergy, Diagn Microbiol Infect Dis, 87, 253, 10.1016/j.diagmicrobio.2016.11.007

Liu YY, 2016, Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study, Lancet Infect Dis, 16, 161, 10.1016/S1473-3099(15)00424-7

Caneiras C, 2018, First description of colistin and tigecycline-resistant Acinetobacter baumannii producing KPC-3 carbapenemase in Portugal, Antibiotics, 7, 10.3390/antibiotics7040096

Morales AS, 2012, Colistin resistance in Escherichia coli and Salmonella entérica strains isolated from swine in Brazil, ScientificWorldJournal, 2012, 10.1100/2012/109795

Perdigão Neto LV, 2019, Fosfomycin in severe infections due to genetically distinct pan-drug-resistant Gram-negative microorganisms: synergy with meropenem, J Antimicrob Chemother, 74, 177, 10.1093/jac/dky406

Samonis G, 2014, Trends of isolation of intrinsically resistant to colistin Enterobacteriaceae and association with colistin use in a tertiary hospital, Eur J Clin Microbiol Infect Dis, 33, 1505, 10.1007/s10096-014-2097-8