Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

Anand, 2008, Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory region, Biochemistry, 47, 6719, 10.1021/bi800309m

Avruch, 2009, The Rassf family of tumor suppressor polypeptides, J. Biol. Chem., 284, 11001, 10.1074/jbc.R800073200

Calvisi, 2006, Ubiquitous activation of Ras and Jak/Stat pathways in human HCC, Gastroenterology, 130, 1117, 10.1053/j.gastro.2006.01.006

Camargo, 2007, YAP1 increases organ size and expands undifferentiated progenitor cells, Curr. Biol., 17, 2054, 10.1016/j.cub.2007.10.039

Chan, 2005, The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1, Oncogene, 24, 2076, 10.1038/sj.onc.1208445

Chan, 2008, A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells, Cancer Res., 68, 2592, 10.1158/0008-5472.CAN-07-2696

Cheung, 2003, Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase, Cell, 113, 507, 10.1016/S0092-8674(03)00355-6

Cinar, 2007, The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1, EMBO J., 26, 4523, 10.1038/sj.emboj.7601872

Dan, 2001, The Ste20 group kinases as regulators of MAP kinase cascades, Trends Cell Biol., 11, 220, 10.1016/S0962-8924(01)01980-8

Dong, 2007, Elucidation of a universal size-control mechanism in Drosophila and mammals, Cell, 130, 1120, 10.1016/j.cell.2007.07.019

Donninger, 2007, The RASSF1A tumor suppressor, J. Cell Sci., 120, 3163, 10.1242/jcs.010389

Fernando, 2002, Caspase 3 activity is required for skeletal muscle differentiation, Proc. Natl. Acad. Sci. USA, 99, 11025, 10.1073/pnas.162172899

Graves, 1998, Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1, EMBO J., 17, 2224, 10.1093/emboj/17.8.2224

Hao, 2008, Tumor suppressor LATS1 is a negative regulator of oncogene YAP1, J. Biol. Chem., 283, 5496, 10.1074/jbc.M709037200

Harvey, 2003, The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis, Cell, 114, 457, 10.1016/S0092-8674(03)00557-9

Huang, 2005, The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP1, Cell, 122, 421, 10.1016/j.cell.2005.06.007

Katagiri, 2006, Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion, Nat. Immunol., 7, 919, 10.1038/ni1374

Katagiri, 2009, Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes, EMBO J., 28, 1319, 10.1038/emboj.2009.82

Lee, 2008, A crucial role of WW45 in developing epithelial tissues in the mouse, EMBO J., 27, 1231, 10.1038/emboj.2008.63

Lee, 2001, MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation, J. Biol. Chem., 276, 19276, 10.1074/jbc.M005109200

Lei, 2008, TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway, Mol. Cell. Biol., 28, 2426, 10.1128/MCB.01874-07

Llovet, 2003, Hepatocellular carcinoma, Lancet, 362, 1907, 10.1016/S0140-6736(03)14964-1

Macheiner, 2009, NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A, Cancer Res., 69, 235, 10.1158/0008-5472.CAN-08-2144

McClatchey, 2005, Membrane organization and tumorigenesis—the NF2 tumor suppressor, Merlin, Genes Dev., 19, 2265, 10.1101/gad.1335605

McPherson, 2004, Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity, EMBO J., 23, 3677, 10.1038/sj.emboj.7600371

Morrison, 2001, The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44, Genes Dev., 15, 968, 10.1101/gad.189601

Murray, 2008, A non-apoptotic role for caspase-9 in muscle differentiation, J. Cell Sci., 121, 3786, 10.1242/jcs.024547

Overholtzer, 2006, Transforming properties of YAP1, a candidate oncogene on the chromosome 11q22 amplicon, Proc. Natl. Acad. Sci. USA, 103, 12405, 10.1073/pnas.0605579103

Praskova, 2004, Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras, Biochem. J., 381, 453, 10.1042/BJ20040025

Praskova, 2008, MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation, Curr. Biol., 18, 311, 10.1016/j.cub.2008.02.006

Reddy, 2008, The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation, Development, 135, 2827, 10.1242/dev.020974

Tapon, 2002, salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines, Cell, 110, 467, 10.1016/S0092-8674(02)00824-3

Udan, 2003, Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway, Nat. Cell Biol., 5, 914, 10.1038/ncb1050

Ura, 2001, Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation, Proc. Natl. Acad. Sci. USA, 98, 10148, 10.1073/pnas.181161698

Vichalkovski, 2008, NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis, Curr. Biol., 18, 1889, 10.1016/j.cub.2008.10.060

Villanueva, 2008, Linking molecular classification of hepatocellular carcinoma and personalized medicine: preliminary steps, Curr. Opin. Oncol., 20, 444, 10.1097/CCO.0b013e328302c9e9

Wu, 2003, hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts, Cell, 114, 445, 10.1016/S0092-8674(03)00549-X

Yi, 2009, The Jekyll and Hyde functions of caspases, Dev. Cell, 16, 21, 10.1016/j.devcel.2008.12.012

Zender, 2006, Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach, Cell, 125, 1253, 10.1016/j.cell.2006.05.030

Zhao, 2007, Inactivation of YAP1 oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control, Genes Dev., 21, 2747, 10.1101/gad.1602907

Zhao, 2008, The Hippo-YAP1 pathway: new connections between regulation of organ size and cancer, Curr. Opin. Cell Biol., 20, 638, 10.1016/j.ceb.2008.10.001

Zhao, 2008, TEAD mediates YAP1-dependent gene induction and growth control, Genes Dev., 22, 1962, 10.1101/gad.1664408

Zhou, 2008, The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells, Proc. Natl. Acad. Sci. USA, 105, 20321, 10.1073/pnas.0810773105