Motor stimulation response by technetium-99m hexamethylpropylene amine oxime split-dose method and single photon emission tomography

European Journal of Nuclear Medicine - Tập 19 - Trang 939-945 - 1992
Patrizia Pantano1, Vittorio Di Piero1, Monica Ricci1, Cesare Fieschi1, Luigi Bozzao1, Gian Luigi Lenzi1
1Department of Neurological Sciences, University of Rome “La Sapienza”, Viale dell' Università, Rome, Italy

Tóm tắt

We applied the technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) split-dose method in order to evaluate the feasibility of assessing cerebral blood flow (CBF) changes with single photon emission tomography (SPET) during a motor activation task. Eleven normal subjects were studied using the Tomomatic 564 (Medimatic, DK). Five subjects were studied twice at rest and 6 subjects at rest and during a motor task performance (finger opposition movements). A total of 28 mCi of 99mTc-HMPAO was injected in 2 doses with a 1:3 ratio. The first scan was obtained after injection of 7 mCi at rest in all subjects. The second scan was obtained a few minutes later, after injection of the remaining dose (21 mCi), under similar resting conditions or during a motor task performance. The mean brain uptake was proportional to the amount of tracer injected and to the acquisition time for both the first scan (5263±1266 counts × mCi × min) and the second (5034.4±966 counts × mCi × min). The grey/white matter ratio was 1.67±0.019 and 1.67±0.097 for the two scans, respectively. A three-way analysis of variance (ANOVA) for repeated measure showed no significant effects of side, slice and region of interest (ROI) on the CBF in the 5 subjects studied twice at rest, and the mean regional CBF change was −0.2%±5%. In the 6 subjects studied at rest and during motor activation, the image subtraction analysis showed a significant CBF increase in the primary motor cortex contralateral to the stimulated side (15%±7%, n=6) and medially in the supplementary motor area (22%±12%, n=4). Our results indicate that the split-dose method allows the detection of a local CBF response to motor activation using 99mTc-HMPAO in a single imaging session.

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European Journal of Nuclear Medicine

Tập 19

939-945

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